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View article: The Systemic Inflammatory Response Syndrome and Predictors of Infection and Mortality in 1068 Critically Ill Newborn Foals
The Systemic Inflammatory Response Syndrome and Predictors of Infection and Mortality in 1068 Critically Ill Newborn Foals Open
Background Sepsis has been defined in humans as the concurrent proven or suspected presence of microbial infection and the systemic inflammatory response syndrome (SIRS). Sepsis is the leading cause of morbidity and mortality in neonatal f…
View article: Women's experiences of learning of the involvement of a partner possessing child abuse material
Women's experiences of learning of the involvement of a partner possessing child abuse material Open
This report presents the executive summary and recommendations from a pilot study exploring women's experiences of learning that their partner possessed child abuse material. Nine Australian women were interviewed, regarding how the offenc…
View article: Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses
Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses Open
Background Ascorbic acid (AA) is an antioxidant that might be beneficial for adjunctive treatment of sepsis in horses. The optimal dose and effects on oxidative status are unknown. Hypothesis Ascorbic acid administration will increase plas…
View article: <scp>ACVIM‐Endorsed</scp> Statements: Consensus statements, <scp>evidence‐based</scp> practice guidelines and systematic reviews
<span>ACVIM‐Endorsed</span> Statements: Consensus statements, <span>evidence‐based</span> practice guidelines and systematic reviews Open
The American College of Veterinary Internal Medicine (ACVIM) has commissioned groups of experts to produce "Consensus Statements" since 2000 to provide veterinarians with information about topics important to ACVIM Diplomates and the veter…
View article: Predictive testing for Huntington's disease : psychosocial contexts and decision-making
Predictive testing for Huntington's disease : psychosocial contexts and decision-making Open
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View article: TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion
TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion Open
Gram-negative bacterial septicemia is mediated through binding of lipopolysaccharide (LPS) to mammalian toll-like receptor protein 4 (TLR4). TLR4 and its cognate protein, myeloid differentiation factor 2 (MD2) form a heterodimeric complex …
View article: Effects of intravenous administration of peripheral blood‐derived mesenchymal stromal cells after infusion of lipopolysaccharide in horses
Effects of intravenous administration of peripheral blood‐derived mesenchymal stromal cells after infusion of lipopolysaccharide in horses Open
Background A systemic and dysregulated immune response to infection contributes to morbidity and mortality associated with sepsis. Peripheral blood‐derived mesenchymal stromal cells (PB‐MSC) mitigate inflammation in animal models of sepsis…
View article: His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation Open
His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) collaborates with endosomal sorting complexes required for transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming the multivesicular body (MVB).…
View article: Effects of administration of ascorbic acid and low‐dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses
Effects of administration of ascorbic acid and low‐dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses Open
Background Sepsis is associated with ascorbic acid (AA) depletion and critical illness‐related corticosteroid insufficiency (CIRCI) in humans. Hypotheses Intravenous infusion of lipopolysaccharide (LPS) would (a) decrease endogneous AA con…
View article: Presumptive tick paralysis in 2 American Miniature horses in the United States
Presumptive tick paralysis in 2 American Miniature horses in the United States Open
Rationale Tick paralysis has not been reported in horses in North America. Clinical Findings Two American Miniature horses were examined for progressive weakness and recumbency. Numerous ticks ( Dermacentor variabilis ) were found on both …
View article: SelProm: A Queryable and Predictive Expression Vector Selection Tool for <i>Escherichia coli</i>
SelProm: A Queryable and Predictive Expression Vector Selection Tool for <i>Escherichia coli</i> Open
The rapid prototyping and optimization of plasmid-based recombinant gene expression is one of the key steps in the development of bioengineered bacterial systems. Often, multiple genes or gene modules need to be coexpressed, and for this p…
View article: Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries
Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries Open
Synthetic biology utilizes the Design–Build–Test–Learn pipeline for the engineering of biological systems. Typically, this requires the construction of specifically designed, large and complex DNA assemblies. The availability of cheap DNA …
View article: Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in <i>Escherichia coli</i>
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in <i>Escherichia coli</i> Open
The field of synthetic biology aims to make the design of biological systems predictable, shrinking the huge design space to practical numbers for testing. When designing microbial cell factories, most optimization efforts have focused on …
View article: Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014‐2018)
Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014‐2018) Open
Background Three flaviviruses (equine pegivirus [EPgV]; Theiler's disease–associated virus [TDAV]; non‐primate hepacivirus [NPHV]) and equine parvovirus (EqPV‐H) are present in equine blood products; the TDAV, NPHV, and EqPV‐H have been su…
View article: Effect of valacyclovir on EHV‐5 viral kinetics in horses with equine multinodular pulmonary fibrosis
Effect of valacyclovir on EHV‐5 viral kinetics in horses with equine multinodular pulmonary fibrosis Open
Background Equine herpesvirus‐5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV‐5 viral kin…
View article: Neonatal Encephalopathy in Calves Presented to a University Hospital
Neonatal Encephalopathy in Calves Presented to a University Hospital Open
Background While studies have examined bovine dystocia in relation to calf survival, little has been published regarding perinatal morbidity and treatment of newborn calves beyond failure of transfer of passive immunity (FTPI). Neonatal en…
View article: Factors Associated with Survival in 97 Horses with Septic Pleuropneumonia
Factors Associated with Survival in 97 Horses with Septic Pleuropneumonia Open
Background Septic pleuropneumonia is a common cause of morbidity and mortality in horses, but there is limited data available regarding factors associated with survival. Hypothesis/Objectives To identify factors predictive of survival in h…
View article: The Effect of Fasting Duration on Baseline Blood Glucose Concentration, Blood Insulin Concentration, Glucose/Insulin Ratio, Oral Sugar Test, and Insulin Response Test Results in Horses
The Effect of Fasting Duration on Baseline Blood Glucose Concentration, Blood Insulin Concentration, Glucose/Insulin Ratio, Oral Sugar Test, and Insulin Response Test Results in Horses Open
Objectives Published descriptions of the oral sugar test (OST) and insulin response test (IRT) have been inconsistent when specifying the protocol for fasting horses before testing. The purpose of our study was to examine the effect of fas…
View article: Cerebrospinal Nematodiasis in 20 Camelids
Cerebrospinal Nematodiasis in 20 Camelids Open
Background Information about the clinical and clinicopathologic aspects of cerebrospinal nematodiasis ( CN ) in camelids is limited. Hypothesis Clinical and therapeutic variables will be identified as factors predictive of survival. Animal…