Dayan Sun
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View article: Diagnostic value of routine biochemical markers for biliary atresia in neonates with cholestasis: a retrospective study
Diagnostic value of routine biochemical markers for biliary atresia in neonates with cholestasis: a retrospective study Open
Background Early diagnosis of biliary atresia (BA) is essential for improving outcomes, but distinguishing it from other causes of neonatal cholestasis (NC) remains difficult. This study aimed to evaluate the diagnostic performance of rout…
View article: Development and Validation of a Screening Model for Early Diagnosis of Biliary Atresia in Neonates with Cholestasis
Development and Validation of a Screening Model for Early Diagnosis of Biliary Atresia in Neonates with Cholestasis Open
Background Biliary atresia (BA) is a progressive neonatal cholestatic liver disease that requires timely diagnosis and intervention. Differentiating BA from other causes of neonatal cholestasis remains a significant clinical challenge. Met…
View article: Application of machine learning in constructing a diagnostic model for neonatal biliary atresia
Application of machine learning in constructing a diagnostic model for neonatal biliary atresia Open
Importance Early diagnosis of biliary atresia (BA) is important for advancing the Kasai operation time and improving the BA prognosis. Objective To develop machine learning (ML) models for neonatal BA diagnosis using clinical characteristi…
View article: MtDNA 3243 A>G mutation and recurrent cholangitis after Kasai procedure in biliary atresia: a case report
MtDNA 3243 A>G mutation and recurrent cholangitis after Kasai procedure in biliary atresia: a case report Open
This article reports a rare case of the mtDNA 3243 A>G mutation presenting as recurrent cholangitis, suggesting that mitochondrial dysfunction may consistently induce inflammation. This case highlights the importance of recognizing mitocho…
View article: The intraoperative localization in recurrent tracheoesophageal fistula after esophageal atresia repair: a comparative study
The intraoperative localization in recurrent tracheoesophageal fistula after esophageal atresia repair: a comparative study Open
LEVEL III.
View article: Clinical outcomes of endoscopic balloon dilation for refractory esophageal strictures after the repair of esophageal atresia
Clinical outcomes of endoscopic balloon dilation for refractory esophageal strictures after the repair of esophageal atresia Open
Endoscopic balloon dilation is an effective method for treating RES after EA repair. GERD, LGEA, eccentric stricture shape, and longer stricture length are the risk factors for increased dilation times. Older age at first dilation after LE…
View article: Bowel Perforation in neonates with Hirschsprung's disease
Bowel Perforation in neonates with Hirschsprung's disease Open
Background Bowel perforation is a severe complication of Hirschsprung's disease (HD) that necessitates prompt diagnosis and aggressive management to reduce mortality and morbidity. This study aimed to provide insights into the clinical man…
View article: Event-Driven Day-Ahead and Intra-Day Optimal Dispatch Strategy for Sustainable Operation of Power Systems Considering Major Weather Events
Event-Driven Day-Ahead and Intra-Day Optimal Dispatch Strategy for Sustainable Operation of Power Systems Considering Major Weather Events Open
As the proportion of renewable energy installations in modern power systems increases, major weather events can easily trigger significant fluctuations in new energy generation and electricity load, presenting the system with the dual chal…
View article: Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies
Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies Open
Metabolic disorders (MDs) are a group of medical conditions that impact the metabolism. These complex processes may have common characteristics among various diseases, thereby suggesting the potential of drug repurposing. Employing Mendeli…
View article: TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis
TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis Open
Objectives Innate immunity significantly contributes to SSc pathogenesis. TLR8 is an important innate immune mediator that is implicated in autoimmunity and fibrosis. However, the expression, mechanism of action, and pathogenic role of TLR…
View article: Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache
Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache Open
Purpose: This study aimed to quantify the different quadrants of the optic nerve head (ONH) and macular parameters and their changes during exposure to high altitude, and to assess their correlation with high-altitude headache (HAH). Metho…
View article: LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis
LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis Open
Treatments for pulmonary fibrosis (PF) are ineffective because its molecular pathogenesis and therapeutic targets are unclear. Here, we show that the expression of low‐density lipoprotein receptor (LDLR) was significantly decreased in alve…
View article: A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function Open
Our findings reveal that mtDNA 827A>G induces aberrant mitochondrial function and abnormal cholesterol transport, resulting in increased occurrence of gallstones. The results provide an important biological basis for the clinical diagnosis…
View article: Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population Open
Mitochondrial DNA (mtDNA) haplogroups have been associated with functional impairments (i.e., decreased gait speed and grip strength, frailty), which are risk factors of disability. However, the association between mtDNA haplogroups and AD…
View article: Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations
Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations Open
Mitochondria are the main producers of energy in eukaryotic cells. Mitochondrial dysfunction is associated with specific mitochondrial DNA (mtDNA) variations (haplogroups), and these variations can contribute to human disease. East Asian p…
View article: Application of multi-sensor Information Fusion Fire Early Warning System in Intelligent Fire Protection Field
Application of multi-sensor Information Fusion Fire Early Warning System in Intelligent Fire Protection Field Open
With the development of MEMS technology, the measurement and determination of many sensitive parameters have been realized, and the interconnection between intelligent sensor network and everything has become possible in hardware.Various s…
View article: Cell Type-Specific Modulation of Respiratory Chain Supercomplex Organization
Cell Type-Specific Modulation of Respiratory Chain Supercomplex Organization Open
Respiratory chain complexes are organized into large supercomplexes among which supercomplex In + IIIn + IVn is the only one that can directly transfer electrons from NADH to oxygen. Recently, it was reported that the formation of supercom…