James Dayre McNally
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View article: Paediatric intensive care unit (PICU) trials: a scoping review protocol
Paediatric intensive care unit (PICU) trials: a scoping review protocol Open
View article: Incidence of Respiratory Syncytial Virus-Associated Hospitalization Among Adults in Ontario, Canada, 2017–2019
Incidence of Respiratory Syncytial Virus-Associated Hospitalization Among Adults in Ontario, Canada, 2017–2019 Open
Background Respiratory syncytial virus (RSV) causes substantial morbidity and mortality among adults. Given recent RSV vaccine authorizations, data on groups at highest risk are needed to support vaccine program decision making. Methods We…
View article: Child and Family Outcomes After PICU Admission: Creation of an Open Access Literature Database Using a Global Team of PICU Specialists Integrated With Machine Learning
Child and Family Outcomes After PICU Admission: Creation of an Open Access Literature Database Using a Global Team of PICU Specialists Integrated With Machine Learning Open
OBJECTIVES: As research examining child health outcomes after PICU admission grows, so does the need for the identification and synthesis of a large body of literature. We aimed to create an open-access scoping repository of literature des…
View article: Teaching high quality paediatric basic life support to laypeople: The development and evaluation of a virtual simulation game
Teaching high quality paediatric basic life support to laypeople: The development and evaluation of a virtual simulation game Open
View article: Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial
Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial Open
View article: Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic
Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic Open
Importance The COVID-19 pandemic created unprecedented challenges for clinical trials worldwide, threatening premature closure and trial integrity. Every phase of research operations was affected, often requiring modifications to protocol …
View article: Measuring continuing medical education conference impact and attendee experience: a scoping review
Measuring continuing medical education conference impact and attendee experience: a scoping review Open
This study identified 8 major domains relevant for continuing medical education conference evaluation. This work is of immediate value to individuals and organizations seeking to either design or evaluate a conference and represents a crit…
View article: Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19 Open
Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals a…
View article: Teaching High Quality Child Cardiopulmonary Resuscitation to Laypeople: The Development and Evaluation of a Virtual Simulation Game
Teaching High Quality Child Cardiopulmonary Resuscitation to Laypeople: The Development and Evaluation of a Virtual Simulation Game Open
View article: Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada
Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada Open
Background Randomized trials conducted in low- and middle-income settings demonstrated efficacy of influenza vaccination during pregnancy against influenza infection among infants <6 months of age. However, vaccine effectiveness (VE) es…
View article: A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)
A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study) Open
Background Vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (ICU) and associated with worse clinical course. Trials in adult ICU demonstrate rapid restoration of vitamin D status using an enteral loading …
View article: Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada
Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada Open
Background Respiratory syncytial virus (RSV) contributes significantly to morbidity in children, placing substantial burdens on health systems, thus RSV vaccine development and program implementation are a public health priority. More data…
View article: Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults
Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults Open
Background Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. Me…
View article: Relationship between Time of Day of Medical Emergency Team Activations and Outcomes of Hospitalized Pediatric Patients
Relationship between Time of Day of Medical Emergency Team Activations and Outcomes of Hospitalized Pediatric Patients Open
This study was conducted to investigate whether outcomes of medical emergency team (MET) activations differ by time of day of hospitalized pediatric patients. This is a retrospective cohort study conduct at a tertiary pediatric hospital. D…
View article: Maternal Vitamin D Status and Gestational Weight Gain as Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada
Maternal Vitamin D Status and Gestational Weight Gain as Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada Open
The implications of maternal gestational weight gain (GWG) and vitamin D status to neonatal bone health are unclear. We tested whether maternal 25-hydroxyvitamin D (25(OH)D) and GWG relate to neonatal bone mineral content (BMC) and bone mi…
View article: Pediatric Chronic Critical Illness: Protocol for a Scoping Review
Pediatric Chronic Critical Illness: Protocol for a Scoping Review Open
Background Improvements in the delivery of intensive care have increased survival among even the most critically ill children, thereby leading to a growing number of children with chronic complex medical conditions in the pediatric intensi…
View article: Health care costs of hospitalization of young children for respiratory syncytial virus infections: a population-based matched cohort study
Health care costs of hospitalization of young children for respiratory syncytial virus infections: a population-based matched cohort study Open
Although the greatest direct medical costs per patient hospitalized with RSV infection are among children with cardiac disease, the greatest overall cost burden is from children born at or near term, who are not targeted by current prophyl…
View article: Evaluation of antibiotic treatment decisions in pediatric intensive care units in Saudi Arabia: A national survey
Evaluation of antibiotic treatment decisions in pediatric intensive care units in Saudi Arabia: A national survey Open
View article: Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study
Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study Open
View article: Pediatric Chronic Critical Illness: Protocol for a Scoping Review (Preprint)
Pediatric Chronic Critical Illness: Protocol for a Scoping Review (Preprint) Open
BACKGROUND Improvements in the delivery of intensive care have increased survival among even the most critically ill children, thereby leading to a growing number of children with chronic complex medical conditions in the pediatric intens…
View article: Successful incorporation of single reviewer assessments during systematic review screening: development and validation of sensitivity and work-saved of an algorithm that considers exclusion criteria and count
Successful incorporation of single reviewer assessments during systematic review screening: development and validation of sensitivity and work-saved of an algorithm that considers exclusion criteria and count Open
Background Accepted systematic review (SR) methodology requires citation screening by two reviewers to maximise retrieval of eligible studies. We hypothesized that records could be excluded by a single reviewer without loss of sensitivity …
View article: Decontamination Interventions for the Reuse of Surgical Mask Personal Protective Equipment: A Protocol for an Updated Systematic Review
Decontamination Interventions for the Reuse of Surgical Mask Personal Protective Equipment: A Protocol for an Updated Systematic Review Open
The COVID-19 pandemic has placed surgical and medical facemask PPE in high demand. Their use spans a variety of healthcare settings and many hospitals have implemented universal masking policies. Furthermore, the emergence of COVID-19 vari…
View article: Pediatric Chronic Critical Illness: A Protocol for a Scoping Review
Pediatric Chronic Critical Illness: A Protocol for a Scoping Review Open
Due to improvements in the delivery of intensive care, survival of even the most critically ill of children has increased, leading to a growing proportion of children with chronic and/or complex medical conditions in the pediatric intensiv…
View article: Influenza Vaccine Effectiveness Against All-Cause Mortality Following Laboratory-Confirmed Influenza in Older Adults, 2010–2011 to 2015–2016 Seasons in Ontario, Canada
Influenza Vaccine Effectiveness Against All-Cause Mortality Following Laboratory-Confirmed Influenza in Older Adults, 2010–2011 to 2015–2016 Seasons in Ontario, Canada Open
Background Older adults are at increased risk of mortality from influenza infections. We estimated influenza vaccine effectiveness (VE) against mortality following laboratory-confirmed influenza. Methods Using a test-negative design study …
View article: Leveraging Health Administrative Data to Investigate Maternal Vulnerabilities in Early Life Respiratory Syncytial Virus (RSV) Hospitalizations in Ontario, Canada
Leveraging Health Administrative Data to Investigate Maternal Vulnerabilities in Early Life Respiratory Syncytial Virus (RSV) Hospitalizations in Ontario, Canada Open
IntroductionRespiratory syncytial virus (RSV) is the leading cause of hospitalization among infants globally. Several RSV vaccine candidates are currently in trial and the severity of RSV-related illness can be reduced with prophylaxis. To…
View article: Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial
Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial Open
View article: Palivizumab’s real-world effectiveness: a population-based study in Ontario, Canada, 1993–2017
Palivizumab’s real-world effectiveness: a population-based study in Ontario, Canada, 1993–2017 Open
Objective To evaluate the effectiveness of two palivizumab programmes targeting high-risk infants, defined by prematurity, diagnosis of comorbidities and geography, and assess potential disparities by neighbourhood income. Design Controlle…
View article: Microwave- and heat-based decontamination of N95 filtering facepiece respirators: a systematic review
Microwave- and heat-based decontamination of N95 filtering facepiece respirators: a systematic review Open
View article: Efficacy and safety of disinfectants for decontamination of N95 and SN95 filtering facepiece respirators: a systematic review
Efficacy and safety of disinfectants for decontamination of N95 and SN95 filtering facepiece respirators: a systematic review Open
A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appe…
View article: Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety
Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety Open