Domenica Donatella Li Puma
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View article: Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke
Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke Open
Early treatment of ischemic stroke can significantly reduce disability and mortality rates. Stem cell-derived extracellular vesicles (EVs) have shown potential as therapeutics for neurological disorders. This study explored whether intrana…
View article: Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity
Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity Open
“A Trojan Horse for Lithium Delivery” . Lithium has important pharmacological applications, although its use is severely limited due to its narrow therapeutic window of administrable concentrations. This study presents a novel nanocarrier …
View article: Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis
Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis Open
View article: Blockade of dopamine <scp>D3</scp> receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype
Blockade of dopamine <span>D3</span> receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype Open
Dopamine D3 receptors (D3Rs) modulate neuronal activity in several brain regions including the hippocampus. Although previous studies reported that blocking D3Rs exerts pro‐cognitive effects, their involvement in hippocampal synaptic funct…
View article: APP/AICD‐dependent expression of Glypican 4 mediates accumulation of tau oligomers in astrocytes and their synaptotoxic action
APP/AICD‐dependent expression of Glypican 4 mediates accumulation of tau oligomers in astrocytes and their synaptotoxic action Open
Background Several studies including ours reported the detrimental effects of extracellular tau oligomers (ex‐oTau) on glutamatergic synaptic transmission and plasticity. Astrocytes greatly internalize ex‐oTau thus contributing to their cl…
View article: Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse
Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse Open
Background The failure of cholinergic transmission and the increase of amyloid‐β peptide (Aβ) and tau protein are key players in Alzheimer’s disease (AD). The interaction between α7 nicotinic acetylcholine receptors (α7‐nAChRs) and Aβ has …
View article: A Bioengineering Strategy to Control ADAM10 Activity in Living Cells
A Bioengineering Strategy to Control ADAM10 Activity in Living Cells Open
A Disintegrin and Metalloprotease 10, also known as ADAM10, is a cell surface protease ubiquitously expressed in mammalian cells where it cuts several membrane proteins implicated in multiple physiological processes. The dysregulation of A…
View article: Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies Open
View article: Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question
Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question Open
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD). However, whether amyloid-β prote…
View article: Ca<sup>2+</sup>‐dependent release of <scp>ATP</scp> from astrocytes affects herpes simplex virus type 1 infection of neurons
Ca<sup>2+</sup>‐dependent release of <span>ATP</span> from astrocytes affects herpes simplex virus type 1 infection of neurons Open
Astrocytes provide metabolic support for neurons and modulate their functions by releasing a plethora of neuroactive molecules diffusing to neighboring cells. Here we report that astrocytes also play a role in cortical neurons' vulnerabili…
View article: Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice
Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice Open
Early diagnosis of Alzheimer's disease (AD) supposedly increases the effectiveness of therapeutic interventions. However, presently available diagnostic procedures are either invasive or require complex and expensive technologies, which ca…
View article: The International Journal of Cell Differentiation and Proliferation
The International Journal of Cell Differentiation and Proliferation Open
View article: P3‐205: NITROSATIVE STRESS‐DEPENDENT NUP153 ALTERATION IMPAIRS NEURAL STEM CELL FUNCTION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
P3‐205: NITROSATIVE STRESS‐DEPENDENT NUP153 ALTERATION IMPAIRS NEURAL STEM CELL FUNCTION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Open
Impairment of adult hippocampal neurogenesis may contribute to cognitive decline in Alzheimer's disease (AD). Besides controlling nucleus-cytoplasm transport, the nuclear pore complex protein Nup153 has been recently described to affect ad…
View article: F2‐06‐02: TRAFFICKING OF TAU OLIGOMERS THROUGH THE PLASMA MEMBRANES OF NEURONS AND ASTROCYTES IS CRITICAL FOR THEIR SYNAPTOTOXICITY
F2‐06‐02: TRAFFICKING OF TAU OLIGOMERS THROUGH THE PLASMA MEMBRANES OF NEURONS AND ASTROCYTES IS CRITICAL FOR THEIR SYNAPTOTOXICITY Open
Tau protein has been recognized to play a key role in Alzheimer's disease pathogenesis. The accepted hypothesis is that hyperphosphorylated and misfolded tau accumulates intraneuronally thus impairing neuronal functions. However, soluble t…
View article: Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory
Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory Open
Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a neurodegenerative disorder characterized by high amounts of the peptide in the brain, raised the question of the physiological role of Aβ released at low …
View article: ForBioEnergy - Forest Bioenergy in the Protected Mediterranean Areas
ForBioEnergy - Forest Bioenergy in the Protected Mediterranean Areas Open
View article: Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Open
High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood. Here, we demonstrate that HFD increases palmitic acid depos…
View article: Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The concurrent application of subtoxic doses of soluble olig…
View article: Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory Open
View article: Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation Open