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View article: Asian Megadeltas: Tackling Coastal Flooding Challenges
Asian Megadeltas: Tackling Coastal Flooding Challenges Open
Integrating scientific insights into current actions is crucial for steering future research directions and underpinning informed management of coastal flooding in Asian deltas.
View article: Gamification in space law: A strategy to navigate the growing landscape
Gamification in space law: A strategy to navigate the growing landscape Open
International audience
View article: Coastal Flooding in Asian Megadeltas: Recent Advances, Persistent Challenges, and Call for Actions Amidst Local and Global Changes
Coastal Flooding in Asian Megadeltas: Recent Advances, Persistent Challenges, and Call for Actions Amidst Local and Global Changes Open
Asian megadeltas, specifically the Ganges‐Brahmaputra‐Meghna, Irrawaddy, Chao Phraya, Mekong, and Red River deltas host half of the world's deltaic population and are vital for Asian countries' ecosystems and food production. These deltas …
View article: An assessment of CO2 storage and sea-air fluxes for the Atlantic Ocean and Mediterranean Sea between 1985 and 2018
An assessment of CO2 storage and sea-air fluxes for the Atlantic Ocean and Mediterranean Sea between 1985 and 2018 Open
From 1985 to 2018, pCO2 products suggest a lower mean CO2 uptake (0.36±0.06 PgC yr -1 ) than ocean models (0.47±0.15 PgC yr -1 )• Since 2000, the CO2 uptake is increasing twice as fast in the pCO2 products compared to the models.• Major di…
View article: Inferring climatic sea-level variations from microatolls in tectonically active regions
Inferring climatic sea-level variations from microatolls in tectonically active regions Open
Coral microatolls are often used to reconstruct the relative sea-level (RSL) along tropical coastlines. They grow at a constant rate, developing each year a growth band that can be observed in their internal stratigraphy. As their developm…
View article: Warming could shift the phenological responses of benthic microalgae in temperate intertidal zones
Warming could shift the phenological responses of benthic microalgae in temperate intertidal zones Open
Intertidal mudflats colonized by sediment-dwelling microphytobenthos deliver a wide range of ecosystem services. Here we simulate the response of microphytobenthos exposed to changes in light, temperature, and sea level conditions on a tem…
View article: An assessment of CO2 storage and sea-air fluxes for the Atlantic Ocean and Mediterranean Sea between 1985 and 2018
An assessment of CO2 storage and sea-air fluxes for the Atlantic Ocean and Mediterranean Sea between 1985 and 2018 Open
From 1985 to 2018, pCO2 products suggest a slightly lower mean CO2 uptake (-0.37±0.06PgC yr -1 ) than ocean models (0.47±0.15 PgC yr -1 )• Since 2000, the CO2 uptake is increasing twice as fast in the pCO2 products compared to the models.•…
View article: Productive mats of micro-algae continue to thrive with a warmer world
Productive mats of micro-algae continue to thrive with a warmer world Open
Intertidal mudflats are amongst the most productive coastal ecosystems on Earth. They are widely spread worldwide supporting food webs and many ecosystem services. Their productivity mostly relies upon mats composed of benthic micro-algae …
View article: A long-term monthly surface water storage dataset for the Congo basin from 1992 to 2015
A long-term monthly surface water storage dataset for the Congo basin from 1992 to 2015 Open
The spatio-temporal variation of surface water storage (SWS) in the Congo River basin (CRB), the second-largest watershed in the world, remains widely unknown. In this study, satellite-derived observations are combined to estimate SWS dyna…
View article: Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice received a single intravenous injection of EO771-derived exosomes (50 µg/mouse; 4E11 particles) or liposomes. Immune composition changes in the lung was assessed 24-hours later by flow cytometry. Frequency of (A) myeloid cells…
View article: Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the tumor microenvironment. Here, we use optical imaging to determine that exogenously a…
View article: Supplementary Figure S6. Changes in immune cell numbers in the lung after continuous conditioning with EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S6. Changes in immune cell numbers in the lung after continuous conditioning with EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice were injected intravenously with 10 μg (7.8E10 particles) of EO771 exosomes or liposomes every three days for 30 days. The number of cells per gram lung tissue of various immune cell populations in the lung was quantified by f…
View article: Supplementary Figure Legends from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure Legends from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Supplementary Figure Legends
View article: Supplementary Figure S1. Isolation and characterization of breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S1. Isolation and characterization of breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
(A) Morphological characterization of exosomes isolated from the conditioned media of EO771 and 4T1 breast cancer cells by transmission electron microscopy. The scale bar indicates 200 nm. B) Detection of exosome-markers, CD9 (25 kDa), TSG…
View article: Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the tumor microenvironment. Here, we use optical imaging to determine that exogenously a…
View article: Supplementary Figure S8. Dose dependent suppression of T-cell proliferation by breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S8. Dose dependent suppression of T-cell proliferation by breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
(A) Percentage of CD8, and CD4 T-cell death after exposure to EO771 exosomes as assessed by staining with the 7-aminoactinomycin D (7-AAD) viability dye. 1 μg of EO771 exosomes is equivalent to 7.9E9 particles. Representative histogram (fl…
View article: Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice received a single intravenous injection of EO771-derived exosomes (50 µg/mouse; 4E11 particles) or liposomes. Immune composition changes in the lung was assessed 24-hours later by flow cytometry. Frequency of (A) myeloid cells…
View article: Supplementary Figure Legends from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure Legends from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Supplementary Figure Legends
View article: Supplementary Figure S6. Changes in immune cell numbers in the lung after continuous conditioning with EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S6. Changes in immune cell numbers in the lung after continuous conditioning with EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice were injected intravenously with 10 μg (7.8E10 particles) of EO771 exosomes or liposomes every three days for 30 days. The number of cells per gram lung tissue of various immune cell populations in the lung was quantified by f…
View article: Supplementary Figure S5. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the bone marrow. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S5. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the bone marrow. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice received a single intravenous injection of EO771-derived exosomes (50 µg/mouse; 4E11 particles), or liposomes. Immune composition changes in the bone marrow was assessed 24-hours later by flow cytometry. Frequency of (A) myelo…
View article: Supplementary Figure S3. Uptake of 4T1- and 67NR-derived exosomes by immune cell lineages. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S3. Uptake of 4T1- and 67NR-derived exosomes by immune cell lineages. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
BALB/C mice received a single intravenous injection of DiD-labeled 4T1- or 67NR-derived exosomes (20 µg; 1.2E11 particles). Liposomes injected at equivalent particle numbers served as control. Assessment of exosome uptake by immune cell li…
View article: Supplementary Figure S8. Dose dependent suppression of T-cell proliferation by breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S8. Dose dependent suppression of T-cell proliferation by breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
(A) Percentage of CD8, and CD4 T-cell death after exposure to EO771 exosomes as assessed by staining with the 7-aminoactinomycin D (7-AAD) viability dye. 1 μg of EO771 exosomes is equivalent to 7.9E9 particles. Representative histogram (fl…
View article: Supplementary Figure S2. Whole body tracking of fluorescently-labeled EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S2. Whole body tracking of fluorescently-labeled EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Representative whole body fluorescent images of C57BL/6 mice at 4, 24 and 48-hours post-intravenous injection of Vybrant® DiD-labeled EO771 exosomes (20 µg; 1.6E11 particles) or liposomes at equivalent particle numbers using the IVIS® Spec…
View article: Supplementary Figure S7. Effect of EO771-derived exosome conditioning on immune composition in the spleen. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S7. Effect of EO771-derived exosome conditioning on immune composition in the spleen. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice were injected intravenously with 10 μg (7.8E10 particles) of EO771 exosomes or liposomes every three days for 30 days. Immune composition changes in the spleen was assessed at endpoint by flow cytometry. Frequency of (A) CD4 (…
View article: Supplementary Figure S3. Uptake of 4T1- and 67NR-derived exosomes by immune cell lineages. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S3. Uptake of 4T1- and 67NR-derived exosomes by immune cell lineages. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
BALB/C mice received a single intravenous injection of DiD-labeled 4T1- or 67NR-derived exosomes (20 µg; 1.2E11 particles). Liposomes injected at equivalent particle numbers served as control. Assessment of exosome uptake by immune cell li…
View article: Supplementary Figure S2. Whole body tracking of fluorescently-labeled EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S2. Whole body tracking of fluorescently-labeled EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Representative whole body fluorescent images of C57BL/6 mice at 4, 24 and 48-hours post-intravenous injection of Vybrant® DiD-labeled EO771 exosomes (20 µg; 1.6E11 particles) or liposomes at equivalent particle numbers using the IVIS® Spec…
View article: Supplementary Figure S5. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the bone marrow. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S5. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the bone marrow. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice received a single intravenous injection of EO771-derived exosomes (50 µg/mouse; 4E11 particles), or liposomes. Immune composition changes in the bone marrow was assessed 24-hours later by flow cytometry. Frequency of (A) myelo…
View article: Supplementary Figure S1. Isolation and characterization of breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S1. Isolation and characterization of breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
(A) Morphological characterization of exosomes isolated from the conditioned media of EO771 and 4T1 breast cancer cells by transmission electron microscopy. The scale bar indicates 200 nm. B) Detection of exosome-markers, CD9 (25 kDa), TSG…