Da Pang
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View article: Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China
Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China Open
Background and objective Obesity is a core risk factor for metabolic diseases, and body mass index (BMI) serves as a key tool for assessing obesity. Current internationally adopted BMI standards (such as the WHO universal standard and the …
View article: Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R
Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R Open
The early detection of circulating tumor DNA (ctDNA) at mutant allele frequencies below 0.1% remains a critical challenge, significantly impeding therapeutic decision‐making. To address this limitation, TIDE‐Cas14a—an innovative CRISPR/Cas…
View article: H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer
H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer Open
Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC…
View article: Genome-wide discovery of circulating cell-free DNA methylation signatures for the differential diagnosis of triple-negative breast cancer
Genome-wide discovery of circulating cell-free DNA methylation signatures for the differential diagnosis of triple-negative breast cancer Open
Background Preoperative identification of breast cancer (BC) subtypes is essential for optimizing treatment strategies and improving patient outcomes. This study aimed to identify circulating cell-free DNA (cfDNA) methylation signatures to…
View article: An Approach for Differential Diagnosis of Breast Tumors by <scp>ctDNA</scp> Methylation Sequencing
An Approach for Differential Diagnosis of Breast Tumors by <span>ctDNA</span> Methylation Sequencing Open
Background Breast ultrasonography and mammography remain predominant in breast tumor evaluations, yet they often result in false positives, particularly for tumors classified as BI‐RADS 4a or those no more than 10 mm, which are not ideal f…
View article: The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity
The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity Open
The FL/ENL/CD38 axis inhibited BC progression. FL enhanced the anticancer effects of PDi by modulating gut microbiota and host immunity.
View article: FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions
FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions Open
This study reveals that HIF-1α promotes FTO transcription under hypoxic conditions, thereby increasing PD-L1 expression through the PDK1/AKT/STAT3 axis. Inhibition of FTO and PDK1 under hypoxic conditions could serve as a promising immunot…
View article: Camrelizumab vs Placebo in Combination With Chemotherapy as Neoadjuvant Treatment in Patients With Early or Locally Advanced Triple-Negative Breast Cancer
Camrelizumab vs Placebo in Combination With Chemotherapy as Neoadjuvant Treatment in Patients With Early or Locally Advanced Triple-Negative Breast Cancer Open
Importance Preferred neoadjuvant strategies for early or locally advanced triple-negative breast cancer include a 4-drug chemotherapy regimen containing anthracyclines, cyclophosphamide, taxanes, and platinum. Blockade of the programmed de…
View article: Pan‐cancer analysis of genome‐wide methylation profiling discover type‐specific markers targeting circulating free DNA for the detection of colorectal cancer
Pan‐cancer analysis of genome‐wide methylation profiling discover type‐specific markers targeting circulating free DNA for the detection of colorectal cancer Open
Dear Editor, Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and cancer-related causes of death worldwide.1 Early diagnosis is critical to provide curable treatment and improving survival rates for CRC patients.2 Circ…
View article: RNA atlas and competing endogenous RNA regulation in tissue-derived exosomes from luminal B and triple-negative breast cancer patients
RNA atlas and competing endogenous RNA regulation in tissue-derived exosomes from luminal B and triple-negative breast cancer patients Open
Background Luminal B and triple-negative breast cancer (TNBC) are malignant subtypes of breast cancer (BC), which can be attributed to the multifaceted roles of tissue-derived exosomes (T-exos). Competing endogenous RNA (ceRNA) networks ca…
View article: Cancer organoids: A platform in basic and translational research
Cancer organoids: A platform in basic and translational research Open
An accumulation of previous work has established organoids as good preclinical models of human tumors, facilitating translation from basic research to clinical practice. They are changing the paradigm of preclinical cancer research because…
View article: Supplementary Table S2 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S2 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S2
View article: Data from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Data from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Long noncoding RNAs (lncRNA) that are associated with immune checkpoints have not been identified, and the mechanism by which such lncRNAs might regulate the expression of immune checkpoints is unknown in human cancer. Immune checkpoint–as…
View article: Supplementary Figures and Legends from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Figures and Legends from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Figures and Legend
View article: Supplementary Table S3 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S3 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S3
View article: Supplementary Table S4 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S4 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S4
View article: Supplementary Table S2 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S2 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S2
View article: Supplementary Table S4 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S4 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S4
View article: Supplementary Table S3 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S3 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S3
View article: Supplementary Table S1 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S1 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S1
View article: Supplementary Table S1 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Table S1 from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Table S1
View article: Data from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Data from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Long noncoding RNAs (lncRNA) that are associated with immune checkpoints have not been identified, and the mechanism by which such lncRNAs might regulate the expression of immune checkpoints is unknown in human cancer. Immune checkpoint–as…
View article: Supplementary Figures and Legends from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer
Supplementary Figures and Legends from Long Noncoding RNAs Control the Modulation of Immune Checkpoint Molecules in Cancer Open
Supplementary Figures and Legend