Adel M. Kamal El‐Dean
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View article: Chemical design, preparation, agricultural bioefficacy valuation, and molecular docking of some pyridine containing compounds
Chemical design, preparation, agricultural bioefficacy valuation, and molecular docking of some pyridine containing compounds Open
The development of effective insecticides is crucial for sustainable agriculture. This research focuses on a series of pyridine derivatives (3–9) that were prepared and evaluated for their agricultural bioefficacy as potential insecticides…
View article: Thiopental-Inspired alkylpyrimidines as dual-target antimicrobial agents: Synthesis, biological activity, and molecular docking validation
Thiopental-Inspired alkylpyrimidines as dual-target antimicrobial agents: Synthesis, biological activity, and molecular docking validation Open
Alkylpyrimidine derivatives, particularly thiopental-based analogs, have emerged as promising scaffolds for antimicrobial drug development. In this study, we designed and synthesized a series of novel thiopental-pyrimidine hybrids (3a–c, 4…
View article: Solvatochromism of new tetraphenylethene luminogens: integration of aggregation-induced emission and conjugation-induced rigidity for emitting strongly in both solid and solution state
Solvatochromism of new tetraphenylethene luminogens: integration of aggregation-induced emission and conjugation-induced rigidity for emitting strongly in both solid and solution state Open
We synthesized and characterized TPE analogs, revealing AIE and solvatochromism. Quantum calculations confirmed diverse behavior due to molecular packing and rigidity. The compounds showed biocompatibility, suggesting potential for cell im…
Potential applications of Aggregation Induced Emission active heterocyclic compounds Open
Heterocyclic compounds are used as a basic structural tool in medicinal chemistry and are very essential in our daily life. A wide range of heterocyclic compounds were reported to show in the literature with interesting biological and phar…
View article: A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions
A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions Open
Synthesis of a sulfonated magnetic cellulose nanocomposite to be applied in Knoevenagel and Thrope–Ziegler reactions. The catalyst promotes a sufficient and facile synthesis methodology for obtaining high-yield products.
View article: Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations
Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations Open
Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single molecule can enhance material behavior dramatically. Here, different …
View article: Base-Free Synthesis and Photophysical Properties of New Schiff Bases Containing Indole Moiety
Base-Free Synthesis and Photophysical Properties of New Schiff Bases Containing Indole Moiety Open
Schiff bases represent an essential class in organic chemistry with antitumor, antiviral, antifungal, and antibacterial activities. The synthesis of Schiff bases requires the presence of an organic base as a catalyst such as piperidine. Ba…
View article: Design, synthesis and antimicrobial screening of some new thienopyrimidines
Design, synthesis and antimicrobial screening of some new thienopyrimidines Open
Heterocyclic compounds play an important role in our life due to their biological importance in the struggle of microorganisms.Herein, a series of novel hybrid compounds of thienopyrimidine with triazine and pyrimidine scaffolds were synth…
View article: An overview on synthesis and reactions of coumarin based compounds
An overview on synthesis and reactions of coumarin based compounds Open
Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins are among the most famous heterocycles which possess one oxygen atom in their rings. Coumarins are classified as multifunctional scaffold …
View article: Synthesis of new distyrylpyridine analogues bearing amide substructure as effective insecticidal agents
Synthesis of new distyrylpyridine analogues bearing amide substructure as effective insecticidal agents Open
In examining for unique insecticidal agents, two derivatives namely, 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)-N-(4-nitrophenyl)acetamide (2) and 3-amino-N-(4-nitrophenyl)-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (3) were synthesiz…
View article: Synthesis, reactions, and applications of pyrimidine derivatives
Synthesis, reactions, and applications of pyrimidine derivatives Open
Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1…
View article: Synthesis, characterization and antimicrobial investigation of new piperidinyl tetrahydrothieno[2,3-c]isoquinolines
Synthesis, characterization and antimicrobial investigation of new piperidinyl tetrahydrothieno[2,3-c]isoquinolines Open
Herein, we describe the synthesis of novel piperidinyl thieno tetrahydroisoquinolines attached or fused to other new heterocycles. The diazotization of the previously synthesized pyrrolyl carbohydrazide 1 followed by several reactions with…
View article: SYNTHESIS AND TOXICOLOGICAL STUDIES ON DISTYRYL-SUBSTITUTED HETEROCYCLIC INSECTICIDES
SYNTHESIS AND TOXICOLOGICAL STUDIES ON DISTYRYL-SUBSTITUTED HETEROCYCLIC INSECTICIDES Open
The toxicity of four pyridine-containing neonicotinoid analogues as potential insecticides against cowpea aphid, Aphis craccivora Koch, has been evaluated. The four pyridine compounds are 2-((2-oxopropyl)thio)-4,6-distyrylnicotinonitrile (…
View article: Synthesis and characterization of some distyryl-derivatives for agricultural uses
Synthesis and characterization of some distyryl-derivatives for agricultural uses Open
Three distyryl-containing compounds, namely, 2-((cyanomethyl)thio)-4,6-distyrylnicotinonitrile ( 2 ), 3-amino-4,6-distyrylthieno[2,3- b ]pyridine-2-carbonitrile ( 3 ) and 2-((2-cyanoethyl)thio)-4,6-distyrylnicotinonitrile ( 4 ) have been p…
View article: A concise review on some synthetic routes and applications of pyridine scaffold compounds
A concise review on some synthetic routes and applications of pyridine scaffold compounds Open
Different methods for the synthesis of pyridine derivatives as well as the chemical reactivity profiles and structures of these substances are reviewed. The utility of these compounds as precursors is emphasized in the synthesis of many he…
View article: Synthesis and spectral characterization of some new thiazolopyrimidine derivatives
Synthesis and spectral characterization of some new thiazolopyrimidine derivatives Open
Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starti…
View article: Synthesis and spectral characterization of selective pyridine compounds as bioactive agents
Synthesis and spectral characterization of selective pyridine compounds as bioactive agents Open
Starting from 3-cyano-4,6-distyrylpyridin-2(1H)-thione (1), the compound N-(4-chlorophenyl)-2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)acetamide (2) was prepared. Compound (2) underwent cyclization upon heating in ethanolic sodium ethoxide …
View article: Synthesis and biological activity of 2-((3-Cyano-4,6-distyrylpyridin-2-yl) thio) acetamide and its cyclized form
Synthesis and biological activity of 2-((3-Cyano-4,6-distyrylpyridin-2-yl) thio) acetamide and its cyclized form Open
In this paper, 2-((3-Cyano-4,6-distyrylpyridin-2-yl)thio)acetamide (2) and its cyclized form, 3-amino-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (3), were prepared and their structure characterizations were performed by the means of e…
View article: Synthesis of Novel Biocompatible Thienopyrimidine Chromophores with Aggregation-Induced Emission Sensitive to Molecular Aggregation
Synthesis of Novel Biocompatible Thienopyrimidine Chromophores with Aggregation-Induced Emission Sensitive to Molecular Aggregation Open
Biocompatible luminogens with aggregation-induced emission (AIE) have several applications in the biology field, such as in detecting biomacromolecules bioprobes and in bio-imaging. Due to their bioactivities and light-emitting properties,…
View article: Erratum to: Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles
Erratum to: Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles Open
An Erratum to this paper has been published: https://doi.org/10.1134/S1068162020060060
View article: Correction to “Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-<i>c</i>]isoquinolines and Related Heterocycles”
Correction to “Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-<i>c</i>]isoquinolines and Related Heterocycles” Open
[This corrects the article DOI: 10.1021/acsomega.9b02604.].
View article: Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-<i>c</i>]isoquinolines and Related Heterocycles
Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-<i>c</i>]isoquinolines and Related Heterocycles Open
A novel series of 1-amino-2-substituted-5-piperidinyl-6,7,8,9-tertahydrothieno[2,3-c]isoquinolines (4a-e) was synthesized upon treatment of 4-cyano-1-piperidinyl-5,6,7,8-tetrahydroisoquinline-3(2H)-thione (2) with α-halo carbonyl compounds…
View article: Phenotypic and Genotypic Characterization of Exopolysaccharide Producing Bacteria Isolated from Fermented Fruits, Vegetables and Dairy Products
Phenotypic and Genotypic Characterization of Exopolysaccharide Producing Bacteria Isolated from Fermented Fruits, Vegetables and Dairy Products Open
Exopolysaccharides (EPS) particularly, from Lactic acid bacteria have received increasing attention in food, medical, and pharmaceutical applications. The present work aims to isolate, characterize and identify exopoly saccharide-producing…
View article: Design, Synthesis, Characterization, and Insecticidal Bioefficacy Screening of Some New Pyridine Derivatives
Design, Synthesis, Characterization, and Insecticidal Bioefficacy Screening of Some New Pyridine Derivatives Open
A lot of insecticides are found nowadays, but neonicotinoids are considered the most famous. So, a series of pyridine derivatives neonicotinoids analogues, namely, 3-cyano-4,6-dimethylpyridine-2(1H)-one (1), 2-chloro-3-cyano-4,6-dimethylpy…
View article: Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2- <i>d</i> ] pyrimidines and related heterocycles
Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2- <i>d</i> ] pyrimidines and related heterocycles Open
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3- c ]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon …
View article: Chemical design and toxicity evaluation of new pyrimidothienotetrahydroisoquinolines as potential insecticidal agents
Chemical design and toxicity evaluation of new pyrimidothienotetrahydroisoquinolines as potential insecticidal agents Open
Neonicotinoids are the most widely used from all existing pesticides. So, in purpose to discover new pesticides being more effective against the aphid, twelve heterocyclic compounds neonicotinoid analogs have been prepared in a pure state;…