Jia Yin
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View article: Calcitonin Gene-Related Peptide Ameliorates Experimental Dry Eye Disease
Calcitonin Gene-Related Peptide Ameliorates Experimental Dry Eye Disease Open
Our data demonstrate that CGRP expression in the cornea and TG is downregulated in DED. Topical CGRP treatment ameliorates DED severity by promoting epithelial proliferation and suppressing inflammation in the cornea.
View article: Supersaturated Oxygen Emulsion Mitigates Hypoxia-Driven Corneal Neovascularization after Alkali Burn
Supersaturated Oxygen Emulsion Mitigates Hypoxia-Driven Corneal Neovascularization after Alkali Burn Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Intracorneal hypopyon within a DSAEK graft
Intracorneal hypopyon within a DSAEK graft Open
Introduction: Intracorneal hypopyon is a rare condition involving the accumulation of inflammatory cells and debris within the structures of the cornea. We present an unusual case of an intracorneal hypopyon within a Descemet-stripping aut…
View article: In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis
In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis Open
CA evaluation can provide hemodynamic status in mild stroke patients with AACLVO/S.
View article: Small Fiber Neuropathy in Patients with Dry Eye Disease
Small Fiber Neuropathy in Patients with Dry Eye Disease Open
Purpose: Small-fiber neuropathy (SFN) refers to a range of peripheral neuropathic conditions affecting small-caliber sensory and/or autonomic nerve fibers. This study aims to determine the prevalence and characteristics of SFN symptoms in …
View article: VEGF-C and 5-Fluorouracil Improve Bleb Survival in a Rabbit Glaucoma Surgery Trabeculectomy Model
VEGF-C and 5-Fluorouracil Improve Bleb Survival in a Rabbit Glaucoma Surgery Trabeculectomy Model Open
Adding VEGF-C lymphoproliferation to standard antimetabolite treatment improved rabbit GFS success and may suggest a future strategy to improve human GFSs.
View article: Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation
Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death
Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death Open
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the bi…
View article: Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety
Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety Open
To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation an…
View article: Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury
Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury Open
Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide abundantly expressed by corneal nerves. Using a murine model of corneal mechanical injury, we found CGRP levels in the cornea to be significantly reduced after injury…
View article: The impacts of diagnosis-intervention packet payment on the providers’ behavior of inpatient care—evidence from a national pilot city in China
The impacts of diagnosis-intervention packet payment on the providers’ behavior of inpatient care—evidence from a national pilot city in China Open
Background In 2020, the Chinese government developed and implemented an innovative case-based payment method under the regional global budget called the diagnosis-intervention packet (DIP) payment to pay for inpatient care. This study aims…
View article: Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model
Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model Open
Background Allergic airway disease (AAD) is a chronic disease characterized by airway inflammation, bronchoconstriction, and hyperresponsiveness. Although exogenous interleukin-10 (IL-10) alleviates allergic inflammation, it has a short ha…
View article: Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice
Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice Open
Background. Corneal transplantation outcomes are generally less favorable in young children compared with adults. The purpose of this study was to determine the immunological mechanisms underlying this difference. Methods. A murine model o…
View article: Descemet Stripping Only Technique for Corneal Endothelial Damage in Mice
Descemet Stripping Only Technique for Corneal Endothelial Damage in Mice Open
Purpose: Descemet stripping only is an emerging surgical technique used to remove central Descemet membrane and corneal endothelial cells in patients with corneal endothelial disease. Here, we describe a murine model of this procedure to h…
View article: Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis
Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis Open
Transdifferentiation of keratocytes into fibroblasts or further into myofibroblasts, which produced denser and more disorganized extracellular matrix, is the major cause of corneal fibrosis and scarring, leading to corneal blindness. TGF-β…
View article: Cultivated autologous limbal epithelial cells (CALEC): product development, manufacture, and initial evaluation of feasibility
Cultivated autologous limbal epithelial cells (CALEC): product development, manufacture, and initial evaluation of feasibility Open
The authors have requested that this preprint be removed from Research Square.
View article: Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film Open
Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. However, the underlying mechanism remains unclear. Herein, we identified that short-term sleep deprivation (SD) resulted in hyper…