Dean E. Natwick
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View article: WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis
WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis Open
Synthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival. However…
View article: WRN Inhibition Leads to its Chromatin-Associated Degradation Via the PIAS4-RNF4-p97/VCP Axis
WRN Inhibition Leads to its Chromatin-Associated Degradation Via the PIAS4-RNF4-p97/VCP Axis Open
Synthetic lethality, the concept in which the co-occurrence of two genetic events leads to cell death while either single event alone does not, is an attractive strategy for targeted cancer therapies. A recent example of synthetic lethalit…
View article: A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties
A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties Open
Targeting common oncogenic drivers of glioblastoma multiforme (GBM) in patients has remained largely ineffective, raising the possibility that alternative pathways may contribute to tumor aggressiveness. Here we demonstrate that Vangl1 and…
View article: Flagella-driven motility is a target of human Paneth cell defensin activity
Flagella-driven motility is a target of human Paneth cell defensin activity Open
In the mammalian intestine, flagellar motility can provide microbes competitive advantage, but also threatens the spatial segregation established by the host at the epithelial surface. Unlike microbicidal defensins, previous studies indica…
View article: Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology
Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology Open
Compartmentalized protein recruitment is a fundamental feature of signal transduction. Accordingly, the cell cortex is a primary site of signaling supported by the recruitment of protein regulators to the plasma membrane. Recent emergence …
View article: Optimized iLID Membrane Anchors for Local Optogenetic Protein Recruitment
Optimized iLID Membrane Anchors for Local Optogenetic Protein Recruitment Open
Optogenetic protein dimerization systems are powerful tools to investigate the biochemical networks that cells use to make decisions and coordinate their activities. These tools, including the improved Light-Inducible Dimer (iLID) system, …
View article: Optimized iLID membrane anchors for local optogenetic protein recruitment
Optimized iLID membrane anchors for local optogenetic protein recruitment Open
Optogenetic protein dimerization systems are powerful tools to investigate the biochemical networks that cells use to make decisions and coordinate their activities. These tools, including the improved Light-Inducible Dimer (iLID) system, …