Dean Everett
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View article: Culture-Based Wastewater Surveillance for the Detection and Monitoring of Antimicrobial Resistance in Staphylococcal Species
Culture-Based Wastewater Surveillance for the Detection and Monitoring of Antimicrobial Resistance in Staphylococcal Species Open
Wastewater-based surveillance (WBS) is valuable for monitoring antimicrobial resistance (AMR). Staphylococci are key targets, as wastewater can facilitate gene transfer and resistance emergence. Data on WBS for population-level AMR in the …
View article: Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Gulf Cooperation Council countries (2010–2025): a scoping review
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Gulf Cooperation Council countries (2010–2025): a scoping review Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern, including within the Gulf Cooperation Council (GCC). As an opportunistic pathogen, MRSA poses a threat to hospitalized patients, and to the wi…
View article: Comparative pangenomics of Streptococcus pneumoniae from Malawi: uncovering genetic variability and pathogenicity
Comparative pangenomics of Streptococcus pneumoniae from Malawi: uncovering genetic variability and pathogenicity Open
Streptococcus pneumoniae is a significant cause of bacterial infections, including pneumonia, meningitis and septicemia, primarily affecting children, the elderly and immunocompromised individuals. This study aimed to elucidate the serotyp…
View article: Methicillin-Resistant Staphylococcus aureus: The Shifting Landscape in the United Arab Emirates
Methicillin-Resistant Staphylococcus aureus: The Shifting Landscape in the United Arab Emirates Open
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in t…
View article: Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum
Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum Open
During antenatal care, gestational diabetes mellitus (GDM) screening is crucial for early diagnosis and treatment to ameliorate clinical outcomes and limit health care expenses. Dietary management and physical activity are central to GDM t…
View article: Critical insights from recent outbreaks of Mycoplasma pneumoniae: decoding the challenges and effective interventions strategies
Critical insights from recent outbreaks of Mycoplasma pneumoniae: decoding the challenges and effective interventions strategies Open
Lessons learned from previous outbreaks underscore the importance of adaptive treatment strategies and proactive management approaches. Addressing these complexities demands a holistic approach integrating advanced technologies, genomic su…
View article: Epidemiology and antimicrobial resistance of Mycobacterium spp. in the United Arab Emirates: a retrospective analysis of 12 years of national antimicrobial resistance surveillance data
Epidemiology and antimicrobial resistance of Mycobacterium spp. in the United Arab Emirates: a retrospective analysis of 12 years of national antimicrobial resistance surveillance data Open
Introduction The Eastern Mediterranean Regional Office (EMRO) region accounts for almost 8% of all global Mycobacterium tuberculosis (TB) cases, with TB incidence rates ranging from 1 per 100,000 per year in the United Arab Emirates (UAE) …
View article: Mapping the Burden of Fungal Diseases in the United Arab Emirates
Mapping the Burden of Fungal Diseases in the United Arab Emirates Open
The United Arab Emirates has very little data on the incidence or prevalence of fungal diseases. Using total and underlying disease risk populations and likely affected proportions, we have modelled the burden of fungal disease for the fir…
View article: Comparison of qPCR and metagenomic sequencing methods for quantifying antibiotic resistance genes in wastewater
Comparison of qPCR and metagenomic sequencing methods for quantifying antibiotic resistance genes in wastewater Open
Surveillance methods of circulating antibiotic resistance genes (ARGs) are of utmost importance in order to tackle what has been described as one of the greatest threats to humanity in the 21 st century. In order to be effective, these met…
View article: Microbial keratitis in Southern Malawi: a microbiological pilot study
Microbial keratitis in Southern Malawi: a microbiological pilot study Open
Objective Microbial keratitis (MK) is a significant cause of blindness in sub-Saharan Africa. We investigated the feasibility of using a novel corneal impression membrane (CIM) for obtaining and processing samples by culture, PCR and whole…
View article: Emergence of highly resistant Candida auris in the United Arab Emirates: a retrospective analysis of evolving national trends
Emergence of highly resistant Candida auris in the United Arab Emirates: a retrospective analysis of evolving national trends Open
Introduction The Centers for Disease Prevention and Control lists Candida auris , given its global emergence, multidrug resistance, high mortality, and persistent transmissions in health care settings as one of five urgent threats. As a ne…
View article: Carbapenem resistant Enterobacterales in the United Arab Emirates: a retrospective analysis from 2010 to 2021
Carbapenem resistant Enterobacterales in the United Arab Emirates: a retrospective analysis from 2010 to 2021 Open
Background Carbapenem-resistant Enterobacterales (CRE) are spreading in the United Arab Emirates (UAE) where their dissemination is facilitated by international travel, trade, and tourism. The objective of this study is to describe the lon…
View article: Methicillin resistant Staphylococcus aureus in the United Arab Emirates: a 12-year retrospective analysis of evolving trends
Methicillin resistant Staphylococcus aureus in the United Arab Emirates: a 12-year retrospective analysis of evolving trends Open
Introduction Methicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains cruc…
View article: Evolving trends among Pseudomonas aeruginosa: a 12-year retrospective study from the United Arab Emirates
Evolving trends among Pseudomonas aeruginosa: a 12-year retrospective study from the United Arab Emirates Open
Introduction Pseudomonas is a group of ubiquitous non-fermenting Gram-negative bacteria (NFGNB). Of the several species associated with humans, Pseudomonas aeruginosa (PA) can acclimate to diverse environments. The global frequency of PA i…
View article: Epidemiology of vancomycin-resistant enterococci in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data
Epidemiology of vancomycin-resistant enterococci in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data Open
Introduction Enterococci are usually low pathogenic, but can cause invasive disease under certain circumstances, including urinary tract infections, bacteremia, endocarditis, and meningitis, and are associated with peritonitis and intra-ab…
View article: Antimicrobial resistance in Streptococcus pneumoniae: a retrospective analysis of emerging trends in the United Arab Emirates from 2010 to 2021
Antimicrobial resistance in Streptococcus pneumoniae: a retrospective analysis of emerging trends in the United Arab Emirates from 2010 to 2021 Open
Introduction Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of Streptococcus pneumoniae infections, there is a paucity of data on the relationship with antimicrobial resistance (AMR) trends in the…
View article: <i>Salmonella enterica</i>serovar Typhimurium ST313 sublineage 2.2 has emerged in Malawi with a characteristic gene expression signature and a fitness advantage
<i>Salmonella enterica</i>serovar Typhimurium ST313 sublineage 2.2 has emerged in Malawi with a characteristic gene expression signature and a fitness advantage Open
Invasive non-typhoidal Salmonella (iNTS) disease is a serious bloodstream infection that targets immune-compromised individuals, and causes significant mortality in sub-Saharan Africa. Salmonella enterica serovar Typhimurium ST313 causes t…
View article: Introduction of a mobile application platform as a decision support tool to enhance antimicrobial stewardship: an experience from the United Arab Emirates
Introduction of a mobile application platform as a decision support tool to enhance antimicrobial stewardship: an experience from the United Arab Emirates Open
Antimicrobial resistance, mainly driven by inappropriate antibiotic use, is a global threat to health, requiring strategies to optimize antimicrobial usage. Antimicrobial stewardship (AMS) programs in hospitals promote the appropriate use …
View article: Impact of antimicrobial stewardship interventions on days of therapy and guideline adherence: A comparative point-prevalence survey assessment
Impact of antimicrobial stewardship interventions on days of therapy and guideline adherence: A comparative point-prevalence survey assessment Open
Background Antimicrobial stewardship (AMS) is a crucial tool for rationalizing the use of antimicrobial agents and reducing the burden of antimicrobial resistance. We aimed to assess the impact of AMS interventions on antimicrobial utiliza…
View article: Pan-genome study underlining the extent of genomic variation of invasive<i>Streptococcus pneumoniae</i>in Malawi
Pan-genome study underlining the extent of genomic variation of invasive<i>Streptococcus pneumoniae</i>in Malawi Open
Streptococcus pneumoniae is a common cause of acute bacterial infections in Malawi. Understanding the molecular mechanisms underlying its invasive behavior is crucial for designing new therapeutic strategies. We conducted a pan-genome anal…
View article: Diabetes and COVID-19: Short- and Long-Term Consequences
Diabetes and COVID-19: Short- and Long-Term Consequences Open
When the corona pandemic commenced more than two years ago, it was quickly recognized that people with metabolic diseases show an augmented risk of severe COVID-19 and an increased mortality compared to people without these comorbidities. …
View article: Obesity and COVID-19: What are the Consequences?
Obesity and COVID-19: What are the Consequences? Open
Obesity is an increasing health problem all over the world. In combination with the current COVID-19 pandemic, this has turned into a massive challenge as individuals with overweight and obesity at all ages show a significant increase in t…
View article: A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV
A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV Open
Pneumococcal serotype 35B is an important non-conjugate vaccine (non-PCV) serotype. Its continued emergence, post-PCV7 in the USA, was associated with expansion of a pre-existing 35B clone (clonal complex [CC] 558) along with post-PCV13 em…
View article: Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci
Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci Open
The isolation of Streptococcus pneumoniae serotypes in systemic tissues of patients with invasive disease versus the nasopharynx of healthy individuals with asymptomatic carriage varies widely. Some serotypes are hyper-invasive, particular…
View article: Clinical pneumonia in the hospitalised child in Malawi in the post-pneumococcal conjugate vaccine era: a prospective hospital-based observational study
Clinical pneumonia in the hospitalised child in Malawi in the post-pneumococcal conjugate vaccine era: a prospective hospital-based observational study Open
Objective Assess characteristics of clinical pneumonia after introduction of pneumococcal conjugate vaccine (PCV), by HIV exposure status, in children hospitalised in a governmental hospital in Malawi. Methods and findings We evaluated 113…
View article: International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease
International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease Open
The total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pne…