H. Dean Hosgood
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Greater ambient air pollution exposure is associated with worse respiratory symptoms in men and women with HIV and chronic lung disease: a cohort study Open
Background COPD and impairment in diffusing capacity for carbon monoxide (DLCO) are common comorbidities in people with HIV (PWH). HIV may increase susceptibility to inhaled toxins including air pollution. In PWH and people without HIV (PW…
View article: Polycystic ovary syndrome diagnosis does not predict increased hidradenitis suppurativa severity
Polycystic ovary syndrome diagnosis does not predict increased hidradenitis suppurativa severity Open
Hidradenitis suppurativa (HS) is a painful inflammatory disorder of follicular biology. Androgens are believed to play a role in HS pathogenesis; however, the mechanism remains unclear. The high frequency of polycystic ovary disease (PCOS)…
View article: Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China
Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China Open
Household air pollution (HAP) is a global health burden affecting about half of the world's population. In Xuanwei, China, individuals experience high concentrations of various HAP constituents, particularly polycyclic aromatic hydrocarbon…
View article: Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers
Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers Open
Background Lung adenocarcinoma in never-smokers is a major public health burden, especially among East Asian women. Polygenic risk scores (PRSs) are promising for risk stratification but are primarily developed in European-ancestry populat…
View article: Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Open
Introduction: Genetic variants associated with nicotine dependence have previously been identified, primarily in European-ancestry populations. No genome-wide association studies (GWAS) have been reported for smoking behaviors in Hispanics…
View article: Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence
Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence Open
Background Lung cancer incidence among never-smoking women in Xuanwei, China, ranks among the highest worldwide and is largely attributed to household air pollution (HAP) from smoky (bituminous) coal combustion, with early-life exposures p…
View article: Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort Open
This study found positive exposure-response associations between low-level benzene exposure and CRC risk in offshore petroleum workers. These findings add to emerging evidence that benzene can be associated with solid tumours including lun…
View article: Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers
Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers Open
Background Lung adenocarcinoma (LUAD) in never-smokers is a major public health burden, especially among East Asian women. Polygenic risk scores (PRSs) are promising for risk stratification but are primarily developed in European-ancestry …
View article: Prevalence and association of polycystic ovary syndrome and hidradenitis suppurativa in underrepresented groups
Prevalence and association of polycystic ovary syndrome and hidradenitis suppurativa in underrepresented groups Open
Hidradenitis suppurativa (HS) is an inflammatory disorder of follicular biology; androgens are believed to be involved in its pathogenesis. Polycystic ovary syndrome (PCOS) is similarly characterized by hyperandrogenism. Previous studies h…
View article: Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China Open
Background The aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Epigenetic alterations, particularly DNA methylation…
View article: Efficacy and Durability of Intravenous Ertapenem Therapy for Recalcitrant Hidradenitis Suppurativa
Efficacy and Durability of Intravenous Ertapenem Therapy for Recalcitrant Hidradenitis Suppurativa Open
Importance Hidradenitis suppurativa (HS) is a debilitating follicular skin disorder in which bacterial colonization is typical. Oral antibiotic efficacy can be unreliable; however, selective intravenous antibiotics, specifically ertapenem,…
View article: Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study
Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study Open
Objective The objective of our study was to examine whether occupational exposure to benzene is associated with lung cancer among males in the Norwegian Offshore Petroleum Workers cohort. Methods Among 25 347 male offshore workers employed…
View article: Similar Efficacy Observed for First-Line Immunotherapy in Racial/Ethnic Minority Patients With Metastatic NSCLC
Similar Efficacy Observed for First-Line Immunotherapy in Racial/Ethnic Minority Patients With Metastatic NSCLC Open
Background: Limited data exist on the impact of immunotherapy use in ethnic minority patients with non–small cell lung cancer (NSCLC), because they have been underrepresented in immunotherapy trials. This study aims to evaluate race/ethnic…
View article: Factors Influencing the Referral of Patients with Prediabetes to a Diabetes Prevention Program in the Bronx, New York
Factors Influencing the Referral of Patients with Prediabetes to a Diabetes Prevention Program in the Bronx, New York Open
We identified under-referral for men and highlighted other patient and health system factors associated with referral rates. Interventions to address bias in referrals and increase referrals for men at high risk for diabetes, not typically…
View article: Coal mining is associated with lung cancer risk in Xuanwei, China
Coal mining is associated with lung cancer risk in Xuanwei, China Open
Background: Xuanwei, China, experiences some of the highest rates of lung cancer in China. While lung cancer risk has been linked to the household use of bituminous coal, no study has comprehensively evaluated the risk of lung cancer assoc…
View article: Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore
Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore Open
Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of…
View article: Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma
Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma Open
Importance Research suggests that increased mitochondrial DNA copy number (mtDNAcn) is associated with increased risk of non-Hodgkin lymphoma (NHL); however, no studies to date have evaluated whether the mitochondrial DNA fraction with bre…
View article: Narrative review: respiratory tract microbiome and never smoking lung cancer
Narrative review: respiratory tract microbiome and never smoking lung cancer Open
These findings suggest potential carcinogenic processes such as increased inflammation associated with changes in flora. Additionally, studies showed that increase in certain taxa such as Bacteroides and Spirochetes might have a protective…