Dean Wu
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View article: Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemic Stroke: A Pilot Study
Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemic Stroke: A Pilot Study Open
BACKGROUND This study aimed to investigate the relationship between the coagulation function measured by thromboelastography (TEG) in patients with acute ischemic stroke (AIS) and total burden of cerebral small vessel disease (CSVD), to fu…
View article: Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice
Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice Open
Background: Epilepsy is a chronic neurological condition with various underlying mechanisms. It is known to affect a multitude of people across the globe, regardless of age and gender. Seizures associated with epilepsy involve the particip…
View article: Pan‑cancer analysis identified ARHGAP23 as a potential biomarker for pancreatic adenocarcinoma
Pan‑cancer analysis identified ARHGAP23 as a potential biomarker for pancreatic adenocarcinoma Open
Rho GTPASE-activating protein 23 (ARHGAP23) is known to activate RHO-GTPase and has an important role in the infiltration and metastasis of tumors. Although previous studies suggested its involvement in certain human cancers, its role in p…
View article: Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities Open
SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work done to date around the world, there is still no viable treatment for COVID-19. Th…
View article: Plasmon-activated water as a therapeutic strategy in Alzheimer’s disease by altering gut microbiota
Plasmon-activated water as a therapeutic strategy in Alzheimer’s disease by altering gut microbiota Open
Gut microbiota (GM) are involved in the pathophysiology of Alzheimer's disease (AD) and might correlate to the machinery of the gut-brain axis. Alteration of the GM profiles becomes a potential therapy strategy in AD. Here, we found that p…
View article: Continuous Positive Airway Pressure Reduces Plasma Neurochemical Levels in Patients with OSA: A Pilot Study
Continuous Positive Airway Pressure Reduces Plasma Neurochemical Levels in Patients with OSA: A Pilot Study Open
Obstructive sleep apnea (OSA) is a risk factor for neurodegenerative diseases. This study determined whether continuous positive airway pressure (CPAP), which can alleviate OSA symptoms, can reduce neurochemical biomarker levels. Thirty pa…
View article: Screening the risk of obstructive sleep apnea by utilizing supervised learning techniques based on anthropometric features and snoring events
Screening the risk of obstructive sleep apnea by utilizing supervised learning techniques based on anthropometric features and snoring events Open
Objectives Obstructive sleep apnea (OSA) is typically diagnosed by polysomnography (PSG). However, PSG is time-consuming and has some clinical limitations. This study thus aimed to establish machine learning models to screen for the risk o…
View article: Associations between risk of Alzheimer's disease and obstructive sleep apnea, intermittent hypoxia, and arousal responses: A pilot study
Associations between risk of Alzheimer's disease and obstructive sleep apnea, intermittent hypoxia, and arousal responses: A pilot study Open
Objectives Obstructive sleep apnea (OSA) may increase the risk of Alzheimer's disease (AD). However, potential associations among sleep-disordered breathing, hypoxia, and OSA-induced arousal responses should be investigated. This study det…
View article: Screening for Obstructive Sleep Apnea Risk by Using Machine Learning Approaches and Anthropometric Features
Screening for Obstructive Sleep Apnea Risk by Using Machine Learning Approaches and Anthropometric Features Open
Obstructive sleep apnea (OSA) is a global health concern and is typically diagnosed using in-laboratory polysomnography (PSG). However, PSG is highly time-consuming and labor-intensive. We, therefore, developed machine learning models base…
View article: Screening the Risk of Obstructive Sleep Apnea by Utilizing Supervised Learning Techniques Based on Anthropometric Features and Snoring Events (Preprint)
Screening the Risk of Obstructive Sleep Apnea by Utilizing Supervised Learning Techniques Based on Anthropometric Features and Snoring Events (Preprint) Open
BACKGROUND Obstructive sleep apnea (OSA) is sleep-disordered breathing and is typically diagnosed by polysomnography (PSG). However, PSG is time-consuming and has some clinical limitations. OBJECTIVE This study thus aimed to establish m…
View article: Differentiation Model for Insomnia Disorder and the Respiratory Arousal Threshold Phenotype in Obstructive Sleep Apnea in the Taiwanese Population Based on Oximetry and Anthropometric Features
Differentiation Model for Insomnia Disorder and the Respiratory Arousal Threshold Phenotype in Obstructive Sleep Apnea in the Taiwanese Population Based on Oximetry and Anthropometric Features Open
Insomnia disorder (ID) and obstructive sleep apnea (OSA) with respiratory arousal threshold (ArTH) phenotypes often coexist in patients, presenting similar symptoms. However, the typical diagnosis examinations (in-laboratory polysomnograph…
View article: Machine learning approaches for screening the risk of obstructive sleep apnea in the Taiwan population based on body profile
Machine learning approaches for screening the risk of obstructive sleep apnea in the Taiwan population based on body profile Open
(a) Objective: Obstructive sleep apnea syndrome (OSAS) is typically diagnosed through polysomnography (PSG). However, PSG incurs high medical costs. This study developed new models for screening the risk of moderate-to-severe OSAS (apnea-h…
View article: Comparison of Hospital-Based and Home-Based Obstructive Sleep Apnoea Severity Measurements with a Single-Lead Electrocardiogram Patch
Comparison of Hospital-Based and Home-Based Obstructive Sleep Apnoea Severity Measurements with a Single-Lead Electrocardiogram Patch Open
Obstructive sleep apnoea (OSA) is a global health concern, and polysomnography (PSG) is the gold standard for assessing OSA severity. However, the sleep parameters of home-based and in-laboratory PSG vary because of environmental factors, …
View article: Air Pollution Associated with Cognitive Decline by the Mediating Effects of Sleep Cycle Disruption and Changes in Brain Structure in Adults
Air Pollution Associated with Cognitive Decline by the Mediating Effects of Sleep Cycle Disruption and Changes in Brain Structure in Adults Open
The effects of air pollution on sleep and dementia remain unclear. The objective of this study was to investigate the effects of air pollution on cognitive function as mediated by the sleep cycle. A cross-sectional study design was conduct…
View article: Hospital-Based Polysomnography May Overestimate Obstructive Sleep Apnoea Severity: Comparison of Hospital-Based and Home-Based Measurements with a Single-Lead Electrocardiogram Patch
Hospital-Based Polysomnography May Overestimate Obstructive Sleep Apnoea Severity: Comparison of Hospital-Based and Home-Based Measurements with a Single-Lead Electrocardiogram Patch Open
Purpose: Obstructive sleep apnoea (OSA) is a global health concern, and polysomnography (PSG) is the gold standard for assessing OSA severity. However, the sleep parameters of home-based and in-laboratory PSG vary because of environmental …
View article: 389 The Association between Arousals and Neurochemical Biomarkers Accumulation in Obstructive Sleep Apnea with Low Arousal Threshold
389 The Association between Arousals and Neurochemical Biomarkers Accumulation in Obstructive Sleep Apnea with Low Arousal Threshold Open
Introduction Previous studies indicated the accumulation of neurodegenerative protein may be caused by higher Obstructive sleep apnea syndrome (OSAS) severity. However, the association between arousal-related parameters induced by OSAS and…
View article: Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease
Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease Open
Background: Parkinson disease (PD), the second most common neurodegenerative disease, has no cure or applicable disease-modifying approach, only symptomatic therapy. Oxidative stress and mitochondrial dysfunction play key roles in PD patho…
View article: Dynamic Prevalence of Sleep Disorders Following Stroke or Transient Ischemic Attack
Dynamic Prevalence of Sleep Disorders Following Stroke or Transient Ischemic Attack Open
Background and Purpose: The exact prevalence of sleep disorders following stroke or transient ischemic attack (TIA) remains unclear. We aimed to determine the prevalence of sleep-disordered breathing, insomnia, periodic leg movement during…
View article: A Wrist Sensor Sleep Posture Monitoring System: An Automatic Labeling Approach
A Wrist Sensor Sleep Posture Monitoring System: An Automatic Labeling Approach Open
In the hospital, a sleep postures monitoring system is usually adopted to transform sensing signals into sleep behaviors. However, a home-care sleep posture monitoring system needs to be user friendly. In this paper, we present iSleePost—a…
View article: Erratum: Lee, H.H., et al. Histone 2A Family Member J Drives Mesenchymal Transition and Temozolomide Resistance in Glioblastoma Multiforme. Cancers 2020, 12, 98
Erratum: Lee, H.H., et al. Histone 2A Family Member J Drives Mesenchymal Transition and Temozolomide Resistance in Glioblastoma Multiforme. Cancers 2020, 12, 98 Open
The authors wish to make the following changes to this paper [...]
View article: Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease Open
In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association betw…
View article: Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial
Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial Open
Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its benefici…
View article: Risk Screening of Obstructive Sleep Apnea Syndrome by Body Profiles via Random Forests Model
Risk Screening of Obstructive Sleep Apnea Syndrome by Body Profiles via Random Forests Model Open
Background Obstructive Sleep Apnea Syndrome (OSAS) is a major global health concern and is typically diagnosed by in-lab polysomnography (PSG). This examination though has high medical manpower costs and alternative portable methods have f…
View article: Correction: Aspirin better than clopidogrel on major adverse cardiovascular events reduction after ischemic stroke: A retrospective nationwide cohort study
Correction: Aspirin better than clopidogrel on major adverse cardiovascular events reduction after ischemic stroke: A retrospective nationwide cohort study Open
[This corrects the article DOI: 10.1371/journal.pone.0221750.].