Deane E. Smith
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View article: Characterizing the Immune Response in Pig-to-Human Heart Xenografts Using a Multimodal Diagnostic System
Characterizing the Immune Response in Pig-to-Human Heart Xenografts Using a Multimodal Diagnostic System Open
BACKGROUND: Porcine genome editing has revolutionized xenotransplantation, recently enabling the first pig-to-human heart xenotransplants. However, the xenoimmune response in heart xenografts remains largely unexplored. This study aimed to…
Single center utilization and post‐transplant outcomes of thoracoabdominal normothermic regional perfusion deceased cardiac donor organs Open
Introduction Thoracoabdominal normothermic regional perfusion (TA‐NRP) following cardiac death is an emerging multivisceral organ procurement technique. Recent national studies on outcomes of presumptive TA‐NRP‐procured organs are limited …
Bridging Over Troubled Waters—How the United States 2018 Heart Allocation System Altered Transplant Bridging Strategies Open
As we approach the five-year anniversary of the 2018 heart allocation system in the United States, it is imperative to consider the changing landscape of mechanical circulatory support and the strategies used to bridge patients into heart …
Extracorporeal Membrane Oxygenation Impact on Host Transcriptomic Response in Severe Coronavirus Open
These findings suggest a temporal impact of ECMO on the host immunotranscriptomic response in patients critically ill with COVID-19.
Supporting the “forgotten” ventricle: The evolution of percutaneous RVADs Open
Right heart failure (RHF) can occur as the result of an acute or chronic disease process and is a challenging clinical condition for surgeons and interventionalists to treat. RHF occurs in approximately 0.1% of patients after cardiac surge…
Experience of Nurses Caring for COVID-19 Patients Supported by Venovenous Extracorporeal Membrane Oxygenation (ECMO) After ECMO Educational Crash Course Open
During a 6 week period beginning early March 2020, 30 patients with severe coronavirus disease 2019 (COVID-19) were supported with venovenous extracorporeal membrane oxygenation (ECMO). This volume increase mandated rapidly training 116 nu…
Efficacy of proning in acute respiratory distress syndrome on extracorporeal membrane oxygenation Open
Proning in patients with ARDS on ECMO is safe with an associated improvement in lung mechanics. With careful planning and coordination, these data support the practice of appropriately proning patients with severe ARDS, even if they are on…
COVID-19-Associated Large- and Medium-Sized-Vessel Pathology: A Case Series Open
Background Coronavirus disease-19 (COVID-19) remains a public health crisis. The epidemiology of COVID-19-associated large- and medium-sized-vessel pathology is not well characterized. The aim of this study is to identify patients with pos…
View article: Utility of D-dimers in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation
Utility of D-dimers in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation Open
A retrospective study was performed examining the trend of inflammatory markers, including D-dimers, in 29 COVID-19 patients requiring veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support. We observed that COVID-19 patients …