Deanna Greenstein
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View article: Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression
Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression Open
The glutamatergic modulator ketamine is associated with changes in sleep, depression, and suicidal ideation (SI). This study sought to evaluate differences in arousal-related sleep metrics between 36 individuals with treatment-resistant ma…
View article: Clinical and electrophysiological correlates of hopelessness in the context of suicide risk✰
Clinical and electrophysiological correlates of hopelessness in the context of suicide risk✰ Open
Hopelessness is a key risk factor for suicide. This analysis explored whether hopelessness indicates a recent suicide crisis state and is linked with magnetoencephalography (MEG) oscillatory power and effective connectivity differences. Ch…
View article: A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine
A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine Open
Background Clinical trials of intravenous (IV) racemic (R,S)-ketamine (hereafter referred to as IV ketamine) have consistently reported rapid and substantial reductions in overall depressive symptoms compared with saline (inactive placebo)…
View article: The Dynamic Relationship Between Alpha and Beta Power and Next-Day Suicidal Ideation in Individuals With Treatment-Resistant Depression
The Dynamic Relationship Between Alpha and Beta Power and Next-Day Suicidal Ideation in Individuals With Treatment-Resistant Depression Open
View article: A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression
A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression Open
Background Ketamine has rapid-acting antidepressant effects but is associated with psychotomimetic and other adverse effects. A 7-chlorokynurenic acid is a potent and specific glycine site N-methyl-d-aspartate receptor antagonist but cross…
View article: Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology
Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology Open
Childhood socioeconomic status (SES) impacts cognitive development and mental health, but its association with human structural brain development is not yet well characterized. Here, we analyzed 1243 longitudinally acquired structural MRI …
View article: Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization
Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization Open
The cerebellum is a large hindbrain structure that is increasingly recognized for its contribution to diverse domains of cognitive and affective processing in human health and disease. Although several of these domains are sex biased, our …
View article: Influences of Brain Size, Sex, and Sex Chromosome Complement on the Architecture of Human Cortical Folding
Influences of Brain Size, Sex, and Sex Chromosome Complement on the Architecture of Human Cortical Folding Open
Gyrification is a fundamental property of the human cortex that is increasingly studied by basic and clinical neuroscience. However, it remains unclear if and how the global architecture of cortical folding varies with 3 interwoven sources…
View article: Cortical thickness change in autism during early childhood
Cortical thickness change in autism during early childhood Open
Structural magnetic resonance imaging (MRI) scans at high spatial resolution can detect potential foci of early brain dysmaturation in children with autism spectrum disorders (ASD). In addition, comparison between MRI and behavior measures…
View article: Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms
Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms Open
View article: Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings
Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings Open
Delayed maturation of occipitotemporal connectivity appears to be a trait marker in patients with COS, with a milder endophenotype in unaffected siblings associated with resilience to developing schizophrenia. These findings indicate genet…