Daniel H. Palmer
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View article: Final results of ANICCA-Class II, a single arm, open-label phase II trial assessing nivolumab in tissue-specific class II expressing metastatic microsatellite stable colorectal cancer, with a parallel assessment of the immunoscore-immune checkpoint as a predictive biomarker for single-agent anti-PD-1
Final results of ANICCA-Class II, a single arm, open-label phase II trial assessing nivolumab in tissue-specific class II expressing metastatic microsatellite stable colorectal cancer, with a parallel assessment of the immunoscore-immune checkpoint as a predictive biomarker for single-agent anti-PD-1 Open
Background Neutralization of interferon (IFN)-γ abrogates the efficacy of anti-programmed death-ligand 1 (PD-(L)1) checkpoint inhibitors. Most epithelial cells do not constitutively express major histocompatibility complex (MHC) class II b…
View article: NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer
NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer Open
Background NAD(P)H quinone dehydrogenase 1 (NQO1), a detoxification enzyme regulated by the Nrf2 cytoprotective pathway, is overexpressed in pancreatic ductal adenocarcinoma (PDAC). NQO1 levels are also influenced by the C609T single-nucle…
View article: Cost-Effectiveness of Biomarker-Associated Early Pancreatic Cancer Detection in New-Onset Diabetes
Cost-Effectiveness of Biomarker-Associated Early Pancreatic Cancer Detection in New-Onset Diabetes Open
Importance Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed late, resulting in a dismal survival. Only 1 in 5 patients is eligible for potentially curative surgery. Although earlier detection of PDAC could significantly improve p…
View article: In-silico evaluation of aging-related interventions using omics data and predictive modeling
In-silico evaluation of aging-related interventions using omics data and predictive modeling Open
A major challenge in aging research is identifying interventions that can improve lifespan and health and minimize toxicity. Clinical studies cannot usually consider decades-long follow-up periods, and therefore, in-silico evaluations usin…
View article: Speech Is Not Enough: Interpreting Nonverbal Indicators of Common Knowledge and Engagement
Speech Is Not Enough: Interpreting Nonverbal Indicators of Common Knowledge and Engagement Open
Our goal is to develop an AI Partner that can provide support for group problem solving and social dynamics. In multi-party working group environments, multimodal analytics is crucial for identifying non-verbal interactions of group member…
View article: Estimating treatment effects using parametric models as counter-factual evidence
Estimating treatment effects using parametric models as counter-factual evidence Open
Randomisation controlled trial are the gold standard for causal inference, however the rapidly increasing development of new treatments and the movement towards personalised medicine mean there is a need to measure efficacy outside of the …
View article: Conserved biological processes in partial cellular reprogramming: Relevance to aging and rejuvenation
Conserved biological processes in partial cellular reprogramming: Relevance to aging and rejuvenation Open
Partial or transient cellular reprogramming is defined by the limited induction of pluripotency factors without full dedifferentiation of cells to a pluripotent state. Comparing in vitro and in vivo mouse studies, and in vitro studies in h…
View article: In-silico Evaluation of Aging-Related Interventions Using Omics Data and Predictive Modeling
In-silico Evaluation of Aging-Related Interventions Using Omics Data and Predictive Modeling Open
A major challenge in aging research is identifying interventions that can improve lifespan and health and minimize toxicity. Clinical studies cannot consider decades-long follow-up periods, and therefore, in-silico evaluations using omics-…
View article: In-silico Evaluation of Aging-Related Interventions Using Omics Data and Predictive Modeling
In-silico Evaluation of Aging-Related Interventions Using Omics Data and Predictive Modeling Open
A major challenge in aging research is identifying interventions that can improve lifespan and health and minimize toxicity. Clinical studies cannot consider decades-long follow-up periods, and therefore, in-silico evaluations using omics-…
View article: Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people
Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people Open
The gut microbiome is amenable to dietary interventions, and polyphenol-rich diets have been shown to enhance abundances of bacteria associated with short-chain fatty acid (SCFA) production. We examined the effects of a strawberry-based in…
View article: Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the two-cell blastomeres differ reciprocally from the start
Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the two-cell blastomeres differ reciprocally from the start Open
Recent advances in embryology have shown that the sister blastomeres of two-cell mouse and human embryos differ reciprocally in potency. An open question is whether the blastomeres became different as opposed to originating as different. H…
View article: Speech Is Not Enough: Interpreting Nonverbal Indicators of Common Knowledge and Engagement
Speech Is Not Enough: Interpreting Nonverbal Indicators of Common Knowledge and Engagement Open
Our goal is to develop an AI Partner that can provide support for group problem solving and social dynamics. In multi-party working group environments, multimodal analytics is crucial for identifying non-verbal interactions of group member…
View article: Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial
Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial Open
PURPOSE The ESPAC4 trial showed that adjuvant chemotherapy with gemcitabine plus capecitabine (GemCap) produced longer overall survival (OS) than gemcitabine monotherapy. Subsequently, the PRODIGE24-CCTG PA.6 trial showed even longer survi…
View article: Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice
Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice Open
The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluat…
View article: Short Take: Investigating the Efficacy and Toxicity of Rejuvenation Interventions
Short Take: Investigating the Efficacy and Toxicity of Rejuvenation Interventions Open
This study investigates the potential risks and mechanisms of action of rejuvenation therapies, focusing on metformin and partial reprogramming, using an integrative approach that combines gene expression, protein interaction networks, and…
View article: Data from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Data from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Purpose:To evaluate the mechanisms of how therapeutic upregulation of the transcription factor, CCAAT/enhancer-binding protein alpha (C/EBPα), prevents tumor progression in patients with advanced hepatocellular carcinoma (HCC) and in diffe…
View article: Supplementary Table 2 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Supplementary Table 2 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Most frequently reported drug related adverse event
View article: Supplementary Data from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Supplementary Data from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Supplementary Figure 1, Supplementary Figure 2, Supplementary Figure 3, Supplementary Figure 4, Supplementary Figure 5, Supplementary Figure 6, Supplementary Figure 7
View article: Supplementary Table 1 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Supplementary Table 1 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Demographic and baseline characteristics
View article: Supplementary Table 3 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Supplementary Table 3 from Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Phenotype of cells used for the analysis of tumour tissues
View article: Chronic hypoxia for the adaptation of extracellular vesicle phenotype
Chronic hypoxia for the adaptation of extracellular vesicle phenotype Open
Variations in oxygen level affect the phenotype of cells and extracellular vesicles (EVs). Depending on the metabolic oxygen demand of cells, hypoxic cell culture can produce conditions more like those found in vivo, and with appropriate o…
View article: Conserved Biological Processes in Partial Cellular Reprogramming: A Comprehensive Review
Conserved Biological Processes in Partial Cellular Reprogramming: A Comprehensive Review Open
Partial or transient cellular reprogramming is defined by the limited induction of pluripotency factors without fully de-differentiating cells into a pluripotent state. Comparing in vitro and in vivo mouse studies, and in vitro studies in …
View article: Multicohort study testing the generalisability of the SASKit-ML stroke and PDAC prognostic model pipeline to other chronic diseases
Multicohort study testing the generalisability of the SASKit-ML stroke and PDAC prognostic model pipeline to other chronic diseases Open
Objectives To validate and test the generalisability of the SASKit-ML pipeline, a prepublished feature selection and machine learning pipeline for the prediction of health deterioration after a stroke or pancreatic adenocarcinoma event, by…
View article: Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice
Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice Open
The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluat…
View article: High-Dose Polyphenol-Rich Nutrition Improves Lipid and Inflammation Profiles and Can Trigger Apoptotic Signaling in Healthy Older Adults (the ErdBEHR Study)
High-Dose Polyphenol-Rich Nutrition Improves Lipid and Inflammation Profiles and Can Trigger Apoptotic Signaling in Healthy Older Adults (the ErdBEHR Study) Open
A high-dose polyphenol-rich nutrition decreases LDL and CRP levels in healthy older adults, and at highest dose, gene expression data highlight "positive regulation of apoptotic signaling".• Top: Study design, escalating the intervention p…