Explanipedia

When the sella is empty: Navigating empty sella syndrome Open

Debabrata Ghosh · 2025

Empty sella syndrome (ESS) is a condition characterized by the herniation of the subarachnoid space into the sella turcica, resulting in a partially or completely empty sella on imaging. It is often discovered incidentally during brain ima…

Risk factors of under-five mortality in Tanzania: insights from the Tanzania Demographic and Health Survey 2022 Open

Md. Sazzad Hossan Sujon, Junayed Ahmmad, Imran Hossain Sumon, Muhammad Asif, Md. Atiar Rahman , et al. · 2025

Background Under-five mortality (U5M) is a key indicator and major concern of population health globally, which reflects the quality of maternal and childcare facilities and health services. Despite the significant decline globally, the ch…

Cross-species efficacy of AAV-mediated ARSA replacement for metachromatic leukodystrophy Open

Shyam Ramachandran, Jeffery Ardinger, Jie Bu, M. Isabel Alcalá Ramos, Lilu Guo , et al. · 2025

Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder caused by mutations in the arylsulfatase A (ARSA) gene, resulting in lower sulfatase activity and the toxic accumulation of sulfatides in the central a…

AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy Open

Sujith Ramachandran, Jeffery Ardinger, Jie Bu, M. Isabel Alcalá Ramos, Lilu Guo , et al. · 2025

Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder caused by mutations in the arylsulfatase A (ARSA) gene, resulting in lower sulfatase activity and the toxic accumulation of sulfatides in the central a…

Ovarian torsion in adolescent Open

Rosalin Hansda, Meghana Pandit, Debabrata Ghosh · 2024

Ovarian torsion is a gynaecological emergency which requires immediate surgical intervention for salvaging ovary and fertility. Ovarian torsions present with acute pelvic pain which is followed by autonomic reflex response (nausea, emesis …

Toxicity Assessment of Local Tobacco Products Bidi and Gul of Bangladesh Using Brine Shrimp (Artemia salina) Lethality Assay Open

Saquib Ahmad Khan, Md. Hafizur Rahman, Shahima Islam, Debabrata Ghosh · 2024

Background: Bidi and gul are two locally produced nicotine-containing tobacco consumables with considerable negative health and environmental impacts, while at the same time, there is a dearth of published data on their toxicology. The LD5…

Tenderness, histomorphology of muscle fiber and gene expression in primal cuts of cattle-A Review Open

Tushar C. Sarker, Rownak Jahan, Robert C. Deen, Debabrata Ghosh, Md. Abul Hashem · 2024

This review focuses on the relationship between tenderness, the structure of muscle fibers (histomorphology) and gene expression in the primal cuts of beef with an emphasis on understanding how these factors contribute to meat quality. Thi…

Sperm intrusion into the implantation-stage blastocyst and its potential biological significance Open

Jayasree Sengupta, Thomas Kroneis, Amy M. Boddy, R. Roy, Anish Sarkar , et al. · 2023

The human embryo derives from fusion of oocyte and sperm, undergoes growth and differentiation, resulting in a blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, allowing access from external inputs. Mode…

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endometrium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle Open

Jeevitha Poorasamy, Deepali Garg, Juhi Bharti, Aruna Nambirajan, Asmita Patil , et al. · 2022

The strong association between endometriosis and infertility is of high clinical significance. High proliferative bias in eutopic endometrium during the secretory phase is a hallmark of endometriosis, which may result in high occurrence of…

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle Open

Jeevitha Poorasamy, Deepali Garg, Juhi Bharti, Aruna Nambirajan, Asmita Patil , et al. · 2022

Several lines of evidence indicate that high proliferative bias in eutopic endometrium during secretory phase is a hallmark of endometriosis and that high occurrence of implantation failure in patients resulting in infertility is often ass…

Sperm in the implantation-stage blastocyst: Is it a check point of embryo quality? Open

Berthold Huppertz, Jayasree Sengupta, Thomas Kroneis, Amy M. Boddy, R. Roy , et al. · 2022

The early human embryo derived from fusion of an oocyte with a single sperm undergoes growth and differentiation and results in an implantation-ready blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, thu…

Progesterone Resistance in Endometriosis Open

Jeevitha Poorasamy, Jayasree Sengupta, Asmita Patil, Debabrata Ghosh · 2022

Endometriosis is characterised by the presence of endometrium-like tissue on the pelvis and other organs. Progesterone resistance due to suppressed progesterone receptor (PGR) expression and action is a general feature of endometriosis and…

Preimplantation Endometrial Transcriptomics in Natural Conception Cycle of the Rhesus Monkey Open

Muzaffer Ahmed Bhat, Meraj A. Khan, Parameswaran Grace Lalitkumar, Jeevitha Poorasamy, Jayasree Sengupta , et al. · 2022

There is no report on preimplantation phase endometrial transcriptomics in natural conception cycles of primates. In the present study, the whole-genome expression array of endometrium on Days 2, 4, and 6 post-ovulation (pov) in proven nat…

Operations perspective to competency-based medical education: Experiences of IUPS-ICMR Physiology Education Workshop series (2018-2019) conducted in India Open

Debabrata Ghosh, DinuS Chandran, Suriya Prakash Muthukrishnan, SusanM Barman, Liisa M. Peltonen , et al. · 2021

The Medical Council of India (MCI; now National Medical Commission, NMC) introduced landmark changes in the medical education landscape of the country in November 2018 by establishing competency-based curriculum as the training method for …

Examining Diagnostic Options and Classification Systems Available for Endometriosis Open

Debabrata Ghosh, Jayasree Sengupta · 2021

Introduction: Endometriosis is characterised by the presence of endometrium-like tissue outside the uterus, and is often associated with chronic pelvic pain, infertility, and compromised quality of life. Development of reliable methods of …

Serum Zinc Level and Its Association with Multidrug-Resistant Tuberculosis Open

Nilima Barman, Md Maruf Haque Khan, Debabrata Ghosh, Muhammad Ibrahim Ibne Towhid, Nasir Uddin , et al. · 2021

Background: Zinc deficiency is evident in chronic diseases, but little is known about its association with multi-drug resistant tuberculosis (MDRTB). We aimed to measure serum zinc level in MDRTB patients and explore its association with M…

Array-based Comparative Genomic Hybridization (aCGH) Reveals Chromosomal Aberrations in Chronic Obstructive Pulmonary Disease (COPD): A Preliminary Study Open

Anjali Trivedi, Debabrata Ghosh, Geetanjali Bade, Randeep Guleria, Meghashree Sampath , et al. · 2021

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease with varying susceptibility. COPD development may be associated with copy number variation (CNV) in susceptible genomic regions. CNV also contributes to COPD heritability as…

Influence of Age, Estrogen receptor (ER),Progesterone receptor (PR) and Epidermal growth factor -2 (HER-2) in Breast Carcinoma Patient in correlation with Radionuclide Bone Scan – Single Institute Based Experience Open

Samira Sharmin, Farida Yasmin, Debabrata Ghosh, Afroza Naznin, Azmal Kabir Sarker , et al. · 2021

Background: Breast carcinoma is a common type of malignancy in women worldwide. Radionuclide bone scintigraphy is recognized choice of investigation for the detection of bone metastases both in asymptomatic and symptomatic patients. Biomar…

Animal experiments in physiology education Open

Debabrata Ghosh, Jayasree Sengupta · 2021

IUPS Physiology Education Workshop series in India: organizational mechanics, outcomes, and lessons Open

D Suba Chandran, Suriya Prakash Muthukrishnan, Susan M. Barman, Liisa M. Peltonen, Sarmishtha Ghosh , et al. · 2020

Active learning promotes the capacity of problem solving and decision making among learners. Teachers who apply instructional processes toward active participation of learners help their students develop higher order thinking skills. Due t…

Contents Open

Geeta Nargund, Bart C.J.M. Fauser, J.M. Jenkins, Sheryl van der Poel, Jan-Steffen Krüssel , et al. · 2020

Pathophysiological Basis of Endometriosis-Linked Stress Associated with Pain and Infertility: A Conceptual Review Open

Debabrata Ghosh, Ludmila Filaretova, Juhi Bharti, Kallol Kumar Roy, Jai Bhagwan Sharma , et al. · 2020

Women with endometriosis are often under stress due to the associated pain, infertility, inflammation-related and other comorbidities including cancer. Additionally, these women are also under stress due to taboos, myths, inter-personal tr…

Physiology without borders: report on physiology education workshops in India—IUPS Initiatives (2018–2019) Open

D Suba Chandran, Suriya Prakash Muthukrishnan, Susan M. Barman, Liisa M. Peltonen, Sarmishtha Ghosh , et al. · 2020

Reference Value for Serum Zinc Level of Adult Population in Bangladesh. Open

Nilima Barman, Marium Salwa, Debabrata Ghosh, Muhammed Waliur Rahman, Nasir Uddin , et al. · 2020

The estimated reference range for serum zinc level in adult population of Bangladesh can serve as a useful indicator for clinical decision making.

An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis Open

Anupa Geethadevi, Jai Bhagwan Sharma, Kallol Kumar Roy, Jayasree Sengupta, Debabrata Ghosh · 2019

Background Previous studies of expression profiles of major endometrial effectors of steroid physiology in endometriosis have yielded markedly conflicting conclusions, presumably because the relative effects of type of endometriosis, ferti…

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence Open

Debabrata Ghosh, Anupa Geethadevi, Bhat MA, Jyotsna Naresh Bharti, Mridha AR , et al. · 2019

Endometriosis is an inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus primarily on pelvic organs and tissues. It affects up to 15% of women in the reproductive age group and is often associate…

Planning, implementation, and evaluation of multicomponent, case-based learning for first-year Indian medical undergraduates Open

Suriya Prakash Muthukrishnan, D Suba Chandran, Naaz Afreen, Megha Bir, Shaon Ghosh Dastidar , et al. · 2019

Didactic lecture is an effective method to quickly pass on a high volume of information to a large number of students. However, if not well designed, lectures can be monotonous and provide only passive learning, with little scope for highe…

Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility Open

Muzaffer Ahmed Bhat, Jai Bhagwan Sharma, Kallol Kumar Roy, Jayasree Sengupta, Debabrata Ghosh · 2019

Cationic antimicrobial peptide, magainin down-regulates secretion of pro-inflammatory cytokines by early placental cytotrophoblasts Open

Anupa Geethadevi, Muzaffer Ahmed Bhat, Akhilesh Kumar Srivastava, Jai Bhagwan Sharma, Nishank Mehta , et al. · 2015

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