Debdutta Bandyopadhyay
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View article: Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor Open
View article: Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes
Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes Open
View article: Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor Open
View article: ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer
ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer Open
Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK in…
View article: Discovery of <i>N</i>-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors
Discovery of <i>N</i>-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors Open
NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into disc…
View article: Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors
Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors Open
View article: Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist
Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist Open
GPR40/FFAR1 is a G protein-coupled receptor predominantly expressed in pancreatic β-cells and activated by long-chain free fatty acids, mediating enhancement of glucose-stimulated insulin secretion. A novel series of substituted 3-(4-arylo…