Debin Xu
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View article: Effects of traditional Chinese exercise on lung function and mental health in patients with COPD: a systematic review and meta-analysis
Effects of traditional Chinese exercise on lung function and mental health in patients with COPD: a systematic review and meta-analysis Open
Objective Despite their widespread use in the management of chronic obstructive pulmonary disease (COPD), pharmacological treatments often demonstrate limited efficacy in alleviating symptoms such as dyspnea and psychological pressure. The…
View article: Causal relationship between gut microbiota and androgenic alopecia A mendelian randomization analysis
Causal relationship between gut microbiota and androgenic alopecia A mendelian randomization analysis Open
Androgenic Alopecia (AGA) is a common condition influenced by genetic and hormonal factors, with emerging evidence linking it to gut microbiota.
View article: Causal relationship between tea intake and chronic pain: A Mendelian randomization study
Causal relationship between tea intake and chronic pain: A Mendelian randomization study Open
Objective: According to some studies, chronic pain imposes a significant burden on individuals and the economy, affecting more than 30% of the global population. However, the relationship between tea intake and chronic pain remains unclear…
View article: Causal Relationship Between Gut Microbiota and Androgenic Alopecia: A Mendelian Randomization Analysis
Causal Relationship Between Gut Microbiota and Androgenic Alopecia: A Mendelian Randomization Analysis Open
Background: Androgenic alopecia (AGA) is a common condition influenced by genetic and hormonal factors, with emerging evidence linking it to gut microbiota. Dysbiosis may affect AGA through immune regulation, androgen metabolism, and syste…
View article: Causal relationship between educational attainment and chronic pain: A Mendelian randomization study
Causal relationship between educational attainment and chronic pain: A Mendelian randomization study Open
Educational attainment (EA) is often used as a symbol of socioeconomic status and is associated with several diseases. However, uncertainty remains regarding the potential relationship between EA and chronic pain. This study aimed to evalu…
View article: The long non-coding RNA CCAT1 promotes erlotinib resistance in cholangiocarcinoma by inducing epithelial-mesenchymal transition via the miR-181a-5p/ROCK2 axis
The long non-coding RNA CCAT1 promotes erlotinib resistance in cholangiocarcinoma by inducing epithelial-mesenchymal transition via the miR-181a-5p/ROCK2 axis Open
Cholangiocarcinoma (CCA) is a common malignancy of the digestive system, and its treatment is greatly challenged by rising chemoresistance. Long non-coding RNAs (lncRNAs) have been shown to play critical roles in the development of drug re…
View article: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex Open
View article: LGALS2 suppresses the progression of papillary thyroid carcinoma by regulating the PI3K/AKT pathway
LGALS2 suppresses the progression of papillary thyroid carcinoma by regulating the PI3K/AKT pathway Open
These data indicate that LGALS2 suppresses PTC progression via PI3K/AKT pathway activation, suggesting that LGALS2 offers value as a treatment target for patients with this cancer type.
View article: TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner. Open
Enhanced aerobic glycolysis contributes to the metastasis of pancreatic cancer metastasis, but the mechanism underlying the abnormal activation of glycolysis has not been fully elucidated. The E3 ligase tripartite motif 16 (TRIM16) is invo…
View article: The E3 Ubiquitin Ligase RBCK1 Promotes The Invasion and Metastasis of Hepatocellular Carcinoma By Destroying The PPARγ/PGC1α Complex
The E3 Ubiquitin Ligase RBCK1 Promotes The Invasion and Metastasis of Hepatocellular Carcinoma By Destroying The PPARγ/PGC1α Complex Open
Background: The disruption of tumour cell metabolism can inhibit tumour metastasis, indicating that aerobic glycolysis is central to tumour development. However, the key factors responsible for mediating aerobic glycolysis in hepatocellula…
View article: RING-finger protein 6 enhances c-Myc-mediated Warburg effect by promoting MAD1 degradation to facilitate pancreatic cancer metastasis.
RING-finger protein 6 enhances c-Myc-mediated Warburg effect by promoting MAD1 degradation to facilitate pancreatic cancer metastasis. Open
Aerobic glycolysis (the Warburg effect) promotes tumor metastasis; hence, drugs targeting its regulators are being developed. c-Myc, a critical transcription factor that regulates the Warburg effect, is involved in the tumorigenesis of man…
View article: Minimally Invasive Video-Assisted Surgical Management for Parapharyngeal Metastases From Papillary Thyroid Carcinoma: A Case Series Report
Minimally Invasive Video-Assisted Surgical Management for Parapharyngeal Metastases From Papillary Thyroid Carcinoma: A Case Series Report Open
Background: Papillary thyroid carcinoma (PTC) is the most prevalent cancer type in the endocrine system. Metastases to parapharyngeal lymph nodes (PPLNs) are rare. Herein, we reported a case series of PTC patients with PPLN metastas…
View article: Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway
Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway Open
Long non-coding RNAs (lncRNAs) have been widely reported that involved in human cancers, including papillary thyroid carcinoma (PTC). The present study aims to investigate the biological role of LINC00982 in PTC. The mRNA expression of LIN…
View article: <p>Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma</p>
Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma Open
Our data indicate that LINC00662 may represent a novel indicator of OSCC and may be a potential therapeutic target for diagnosis and therapy.
View article: Anaphylactic Reactions to Isosulfan Blue Dye During Sentinel Lymph Node Biopsy for Breast Cancer
Anaphylactic Reactions to Isosulfan Blue Dye During Sentinel Lymph Node Biopsy for Breast Cancer Open
Background: The sentinel lymph node biopsy is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction to the isosulfan blue dye used during sentinel lymph node biopsy have recently been reporte…
View article: Special role of JUN in papillary thyroid carcinoma based on bioinformatics analysis
Special role of JUN in papillary thyroid carcinoma based on bioinformatics analysis Open
View article: Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma
Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma Open
This study evaluated the predictive value of the preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current study enrolled 241 newly diagnosed LSCC…
View article: Pretreatment BMI Is Associated with Aggressive Clinicopathological Features of Papillary Thyroid Carcinoma: A Multicenter Study
Pretreatment BMI Is Associated with Aggressive Clinicopathological Features of Papillary Thyroid Carcinoma: A Multicenter Study Open
Objectives . The aim of the present study was to analyze the association between pretreatment body mass index (BMI) and the aggressiveness of papillary thyroid carcinoma (PTC) along with its clinical outcomes in a Chinese population with B…