Debjani Paul
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View article: Microfluidics and nanofluidics in India – some recent advancements and futuristic perspective
Microfluidics and nanofluidics in India – some recent advancements and futuristic perspective Open
View article: An in silico design method of a peptide bioreceptor for cortisol using molecular modelling techniques
An in silico design method of a peptide bioreceptor for cortisol using molecular modelling techniques Open
Cortisol is established as a reliable biomarker for stress prompting intensified research in developing wearable sensors to detect it via eccrine sweat. Since cortisol is present in sweat in trace quantities, typically 8-140 ng/mL, develop…
View article: Measuring red blood cell deformability and its heterogeneity using a fast microfluidic device
Measuring red blood cell deformability and its heterogeneity using a fast microfluidic device Open
Red blood cells (RBCs) are more deformable than most other cells in the body, and any change in the deformability of RBCs can have major physiological effects. Here, we report a high-throughput microfluidic device to determine the Young's …
View article: Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care
Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care Open
Red blood cells (RBCs) become sickle‐shaped and stiff under hypoxia as a consequence of hemoglobin (Hb) polymerization in sickle cell anemia. Distinguishing between sickle cell disease and trait is crucial during the diagnosis of sickle ce…
View article: An insilico design of a peptide bioreceptor for cortisol using molecular modelling techniques
An insilico design of a peptide bioreceptor for cortisol using molecular modelling techniques Open
Cortisol is established as a reliable biomarker for stress prompting intensified research in developing wearable sensors to detect it via eccrine sweat. Since cortisol is present in sweat in trace quantities, typically 8-140ng/mL, developi…
View article: Measuring RBC deformability and its heterogeneity using a fast microfluidic device
Measuring RBC deformability and its heterogeneity using a fast microfluidic device Open
SUMMARY We report a high-throughput microfluidic device to determine the Young’s modulus of single red blood cells (RBCs). Our device consists of a single channel opening into a funnel, with a semi-circular obstacle placed at the mouth of …
View article: Portable absorbance platform for sensing of viral and bacterial nucleic acid leveraging intercalation with methylene blue: Application for wastewater-based epidemiology
Portable absorbance platform for sensing of viral and bacterial nucleic acid leveraging intercalation with methylene blue: Application for wastewater-based epidemiology Open
Monitoring the presence of viruses and bacteria in environmental reservoirs such as wastewater, lake water etc. is a very useful tool for early detection and controlling the spread of diseases, while also helping estimate the severity of i…
View article: Pump-free and high-throughput generation of monodisperse hydrogel beads by microfluidic step emulsification for dLAMP-on-a-chip
Pump-free and high-throughput generation of monodisperse hydrogel beads by microfluidic step emulsification for dLAMP-on-a-chip Open
Step emulsification (SE), which generates droplets by a sharp change in confinement, has emerged as a potential alternative to flow-focusing technology. Water/dispersed phase is continuously pumped through a shallow inlet channel into a de…
View article: Anti-nucleolin aptamer mediated specific detection of cancer cells by Localized Surface Plasmon Resonance-based U-bent optical fiber
Anti-nucleolin aptamer mediated specific detection of cancer cells by Localized Surface Plasmon Resonance-based U-bent optical fiber Open
The detection of Circulating Tumor Cells (CTCs) is of profound importance for cancer diagnosis and monitoring in diseased patients. In the presented work, an aptasensor for CTC detection was developed using AS1411 aptamer specific for nucl…
View article: Measuring Red Blood Cell Deformability and its Heterogeneity Using a Fast Microfluidic Device
Measuring Red Blood Cell Deformability and its Heterogeneity Using a Fast Microfluidic Device Open
View article: A low-cost and portable centrifugal microfluidic platform for continuous processing of large sample volumes
A low-cost and portable centrifugal microfluidic platform for continuous processing of large sample volumes Open
Centrifugal microfluidic platforms are becoming increasing popular in many research and diagnostic applications. A major challenge in centrifugal microfluidics is continuous handling of large sample volumes. Keeping the flow rate constant …
View article: Anomalous diffusion of<i>E. coli</i>under microfluidic confinement and chemical gradient
Anomalous diffusion of<i>E. coli</i>under microfluidic confinement and chemical gradient Open
We report a two-layer microfluidic device to study the combined effect of confinement and chemical gradient on the motility of wild type E. coli . We track individual E. coli in 50 μm and 10 μm wide channels, with a channel height of 2.5 μ…
View article: Development of an insilico model of eccrine sweat using molecular modelling techniques
Development of an insilico model of eccrine sweat using molecular modelling techniques Open
Eccrine sweat is an ideal surrogate diagnostic biofluid for physiological and metabolic biomarkers for wearable biosensor design. Its periodic and non-invasive availability for candidate analytes such as glucose and cortisol along with lim…
View article: Development of an insilico model of eccrine sweat using molecular modelling techniques
Development of an insilico model of eccrine sweat using molecular modelling techniques Open
Exploring eccrine sweat as an ideal surrogate diagnostic biofluid for physiological and metabolic biomarkers, which are indicators of human health and performance, is an area of significant research interest. These biomarkers correlate wel…
View article: Haemoprocessor: A Portable Platform Using Rapid Acoustically Driven Plasma Separation Validated by Infrared Spectroscopy for Point-of-Care Diagnostics
Haemoprocessor: A Portable Platform Using Rapid Acoustically Driven Plasma Separation Validated by Infrared Spectroscopy for Point-of-Care Diagnostics Open
The identification of biomarkers from blood plasma is at the heart of many diagnostic tests. These tests often need to be conducted frequently and quickly, but the logistics of sample collection and processing not only delays the test resu…
View article: Exploring the concentration-dependent transport and the loss of rhodamine B, tartrazine, methylene blue, and amaranth dyes in common paperfluidic substrates
Exploring the concentration-dependent transport and the loss of rhodamine B, tartrazine, methylene blue, and amaranth dyes in common paperfluidic substrates Open
View article: Single Test Image-Based Automated Machine Learning System for\n Distinguishing between Trait and Diseased Blood Samples
Single Test Image-Based Automated Machine Learning System for\n Distinguishing between Trait and Diseased Blood Samples Open
We introduce a machine learning-based method for fully automated diagnosis of\nsickle cell disease of poor-quality unstained images of a mobile microscope.\nOur method is capable of distinguishing between diseased, trait (carrier), and\nno…
View article: Single Test Image-Based Automated Machine Learning System for Distinguishing between Trait and Diseased Blood Samples
Single Test Image-Based Automated Machine Learning System for Distinguishing between Trait and Diseased Blood Samples Open
We introduce a machine learning-based method for fully automated diagnosis of sickle cell disease of poor-quality unstained images of a mobile microscope. Our method is capable of distinguishing between diseased, trait (carrier), and norma…
View article: Temperature-dependent Self assembly of biofilaments during red blood cell sickling
Temperature-dependent Self assembly of biofilaments during red blood cell sickling Open
Molecular self-assembly plays vital role in various biological functions. However, when aberrant molecules self-assemble to form large aggregates, it can give rise to various diseases. For example, the sickle cell disease and Alzheimer’s d…
View article: Differential sensitivity to hypoxia enables shape-based classification of sickle cell disease and trait blood samples
Differential sensitivity to hypoxia enables shape-based classification of sickle cell disease and trait blood samples Open
Differentiating between homozygous (disease) and heterozygous (trait) sickle cell patients is the key to ensuring appropriate long-term disease management. Well-equipped labs needed to perform confirmatory diagnostic tests are not availabl…
View article: Developing a Point-of-Care Molecular Test to Detect SARS-CoV-2
Developing a Point-of-Care Molecular Test to Detect SARS-CoV-2 Open
View article: Label-Free Electrochemical Detection of S. mutans Exploiting Commercially Fabricated Printed Circuit Board Sensing Electrodes
Label-Free Electrochemical Detection of S. mutans Exploiting Commercially Fabricated Printed Circuit Board Sensing Electrodes Open
This paper reports for the first time printed-circuit-board (PCB)-based label-free electrochemical detection of bacteria. The demonstrated immunosensor was implemented on a PCB sensing platform which was designed and fabricated in a standa…
View article: Influence of probe geometry of optical fibers in sensing volatile liquids through localized surface plasmon resonance
Influence of probe geometry of optical fibers in sensing volatile liquids through localized surface plasmon resonance Open
A comprehensive analysis of influence of probe geometry on localized surface plasmon resonance phenomenon is presented. Plasmonic responses of noble metal nanoparticles such as AuNPs and AgNPs have been exclusively examined by adopting D-t…
View article: A fast microfluidic device to measure the deformability of red blood cells
A fast microfluidic device to measure the deformability of red blood cells Open
We report a microfluidic device to determine the shear elastic modulus and the Young’s modulus of red blood cells (RBCs). Our device consists of a single channel opening into a funnel, with a semi-circular obstacle placed at the mouth of t…
View article: An integrated one-step assay combining thermal lysis and loop-mediated isothermal DNA amplification (LAMP) in 30 min from<i>E. coli</i>and<i>M. smegmatis</i>cells on a paper substrate
An integrated one-step assay combining thermal lysis and loop-mediated isothermal DNA amplification (LAMP) in 30 min from<i>E. coli</i>and<i>M. smegmatis</i>cells on a paper substrate Open
Developing sensors in the domains of food safety, soil analysis, water quality monitoring and healthcare often requires distinguishing between different species of bacteria. The most rapid, sensitive and specific method to identify bacteri…
View article: Fabrication of miniature elastomer lenses with programmable liquid mold for smartphone microscopy: curing polydimethylsiloxane with in situ curvature control
Fabrication of miniature elastomer lenses with programmable liquid mold for smartphone microscopy: curing polydimethylsiloxane with in situ curvature control Open
Miniature lenses can transform commercial imaging systems, e.g., smartphones and webcams, into powerful, low-cost, handheld microscopes. To date, the reproducible fabrication of polymer lenses is still a challenge as they require controlle…
View article: Clogging-free continuous operation with whole blood in a radial pillar device (RAPID)
Clogging-free continuous operation with whole blood in a radial pillar device (RAPID) Open
Pillar-based passive microfluidic devices combine the advantages of simple designs, low device footprint, and high selectivity for size-based separation of blood cells. Most of these device designs have been validated with dilute blood sam…
View article: A radial pillar device (RAPID) for continuous and high-throughput separation of multi-sized particles
A radial pillar device (RAPID) for continuous and high-throughput separation of multi-sized particles Open
Pillar-based microfluidic sorting devices are preferred for isolation of rare cells due to their simple designs and passive operation. Dead-end pillar filters can efficiently capture large rare cells, such as, circulating tumor cells (CTCs…