Debleena Ray
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View article: Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73
Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73 Open
The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell death and also supports tumorigenesis, although the mechanistic basis for the dichotomous functions is poorly understood. We report here the identifi…
View article: 532 Anti-VISTA antibody HMBD-002 reprograms tumour associated macrophages and promotes cytotoxic T cell response
532 Anti-VISTA antibody HMBD-002 reprograms tumour associated macrophages and promotes cytotoxic T cell response Open
Background VISTA is an emerging, predominantly myeloid, immune checkpoint, and its blockade has shown benefit in multiple preclinical models of cancer as both a monotherapy and in combination with other immune checkpoint inhibitors (ICI) s…
Tumorigenic de-differentiation: the alternative splicing way Open
The mechanism of acquisition of tumorigenic properties by somatic cells at the onset of cancer and later during relapse is a question of paramount importance in cancer biology. We have recently discovered a Muscleblind like-1 (MBNL1)-drive…
A tumor-associated splice-isoform of <i>MAP2K7</i> drives dedifferentiation in MBNL1-low cancers via JNK activation Open
Significance Targeting stem-like cells in cancer is critical to overcoming resistance and relapse post chemotherapy or immunotherapy. We elucidate an alternative-splicing driven mechanism of cancer dedifferentiation and define a molecular …
A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors Open
Comprehensive understanding of aberrant splicing in gastric cancer is lacking. We RNA-sequenced 19 gastric tumor–normal pairs and identified 118 high-confidence tumor-associated (TA) alternative splicing events (ASEs) based on high-coverag…
RAS activation via CRLF2 signaling is a widespread mechanism in Down syndrome acute lymphoblastic leukemia regardless of RAS mutations Open
Background Down syndrome acute lymphoblastic leukemia (DS-ALL) is characterized by the high frequency of CRLF2-rearrangements, JAK2-mutations, or RAS-pathway mutations. Intriguingly, JAK2 and RAS mutations are mutually exclusive in leukemi…
View article: Sperm Motility Regulatory Proteins: A Tool to Enhance Sperm Quality
Sperm Motility Regulatory Proteins: A Tool to Enhance Sperm Quality Open
Sperm forward motility is an essential parameter in mammalian fertilization. Studies from our laboratory have identified and characterized a few unique sperm motility regulatory proteins/glycoproteins from the male reproductive fluids and …