Deboki Naskar
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View article: Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites Open
Malaria parasites are highly divergent from model eukaryotes. Large-scale genome engineering methods effective in model organisms are frequently inapplicable, and systematic studies of gene function are few. We generated more than 175,000 …
View article: The structure of a <i>Plasmodium vivax</i> Tryptophan Rich Antigen suggests a lipid binding function for a pan-<i>Plasmodium</i> multi-gene family
The structure of a <i>Plasmodium vivax</i> Tryptophan Rich Antigen suggests a lipid binding function for a pan-<i>Plasmodium</i> multi-gene family Open
Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family in all Plasmodium species, significantly expanded in P. vivax , but their function is not currently known. We show that multiple P. vivax TRAgs are expressed on the merozo…
View article: Nonmulberry silk proteins: multipurpose ingredient in bio-functional assembly
Nonmulberry silk proteins: multipurpose ingredient in bio-functional assembly Open
The emerging field of tissue engineering and regenerative medicines utilising artificial polymers is facing many problems. Despite having mechanical stability, non-toxicity and biodegradability, most of them lack cytocompatibility and bioc…
View article: CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis
CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis Open
The microenvironment contributes to the excessive connective tissue deposition that characterizes fibrosis. Members of the CCN family of matricellular proteins are secreted by fibroblasts into the fibrotic microenvironment; however, the ro…
View article: Engineering silk biomaterials for cancer therapy
Engineering silk biomaterials for cancer therapy Open
2D models are failing to predict the accuracy and efficiency of cancer therapeutics. Thus 3D culture systems are adapted to unwind true structural and functional cancerous microenvironment. In situ, cancer microenvironment contains extrac…
View article: Cover Image, Volume 11, Issue 11
Cover Image, Volume 11, Issue 11 Open
The cover image, by Vishal Chaturvedi et al., is based on the Research Article Silk fibroin scaffolds with muscle-like elasticity support in vitro differentiation of human skeletal muscle cells, DOI: 10.1002/term.2227.
View article: Silk fibroin scaffolds with muscle-like elasticity support<i>in vitro</i>differentiation of human skeletal muscle cells
Silk fibroin scaffolds with muscle-like elasticity support<i>in vitro</i>differentiation of human skeletal muscle cells Open
Human adult skeletal muscle has a limited ability to regenerate after injury and therapeutic options for volumetric muscle loss are few. Technologies to enhance regeneration of tissues generally rely upon bioscaffolds to mimic aspects of t…