Débora Rasec Radulski
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View article: Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta
Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta Open
The present study aimed to evaluate the composition of the crude extracts obtained from the leaves of Cantinoa stricta (Lamiaceae) and explore the antinociceptive and anti-inflammatory activity of these extracts and two isolated compounds:…
View article: Features and applications of Ehrlich tumor model in cancer studies: a literature review
Features and applications of Ehrlich tumor model in cancer studies: a literature review Open
Ehrlich tumors are a relevant tool for improving our understanding of the pathogenesis of breast cancer and investigating the tumor microenvironment, side effects of therapies, and new treatment options. Despite some limitations, such as t…
View article: A Single Injection of Pregabalin Induces Short- and Long-Term Beneficial Effects on Fear Memory and Anxiety-Like Behavior in Rats with Experimental Type-1 Diabetes Mellitus.
A Single Injection of Pregabalin Induces Short- and Long-Term Beneficial Effects on Fear Memory and Anxiety-Like Behavior in Rats with Experimental Type-1 Diabetes Mellitus. Open
Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type 1 diabetes mellitus (DM1) are increasingly common comorbidities and the treatment is quite challenging. In that sense, evidence indicates that the anticonvuls…
View article: Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania
Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania Open
View article: Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms
Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms Open
Natural products have been recognized as important bioactive compounds on the basis of their wide biological properties. Here we investigated the antitumor effect and molecular mechanisms of the diterpene Fruticuline A (fruti) from Salvia …
View article: Immune-mediated febrile response in female rats: Role of central hypothalamic mediators
Immune-mediated febrile response in female rats: Role of central hypothalamic mediators Open
Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (S…
View article: Sistema RANK/RANKL/OPG na resposta febril induzida por endotoxina em ratos machos e fêmeas
Sistema RANK/RANKL/OPG na resposta febril induzida por endotoxina em ratos machos e fêmeas Open