Deborah Cromer
YOU?
Author Swipe
View article: Health impact and cost-effectiveness of COVID-19 booster vaccination strategies in the early post-Omicron era: a dynamic modelling study
Health impact and cost-effectiveness of COVID-19 booster vaccination strategies in the early post-Omicron era: a dynamic modelling study Open
Introduction Following widespread exposure to Omicron variants, SARS-CoV-2 has transitioned to endemic circulation. Populations now have diverse infection and vaccination histories, resulting in heterogeneous immune landscapes. Careful con…
View article: Towards evidence-based immunology
Towards evidence-based immunology Open
View article: Macrophages direct location-dependent recall of B cell memory to vaccination
Macrophages direct location-dependent recall of B cell memory to vaccination Open
View article: Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens
Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens Open
The ongoing rollout of SARS-CoV-2 vaccines lags behind rapid viral evolution. Updated vaccine immunogens elicit neutralising antibodies against the component strain. However, protection against future SARS-CoV-2 variants is unclear. Here, …
View article: Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques
Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques Open
In cases of HIV transmission, the typical delay from exposure to detectable viremia is approximately one week. This delay from exposure to viremia suggests that during initial expansion of virus from a limited number of founder lineages, t…
View article: Predicting immune protection against outcomes of infectious disease from population-level effectiveness data with application to COVID-19
Predicting immune protection against outcomes of infectious disease from population-level effectiveness data with application to COVID-19 Open
View article: Randomized trial of same- versus opposite-arm coadministration of inactivated influenza and SARS-CoV-2 mRNA vaccines
Randomized trial of same- versus opposite-arm coadministration of inactivated influenza and SARS-CoV-2 mRNA vaccines Open
BACKGROUNDThe immunogenicity of current influenza vaccines needs improvement. Inactivated influenza and COVID-19 mRNA vaccines can be coadministered, but randomized controlled trial data are lacking on whether the 2 vaccines are more immun…
View article: High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection
High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection Open
View article: Optimal deployment of limited vaccine supplies to combat mpox
Optimal deployment of limited vaccine supplies to combat mpox Open
Mpox outbreaks in Central Africa have been declared a public health emergency of international concern by the World Health Organization. Fortunately, real-world effectiveness studies of the MVA-BN vaccine indicate that it has an effectiven…
View article: Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates
Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates Open
View article: Optimal timing of booster doses in a highly vaccinated population with minimal natural exposure to COVID-19
Optimal timing of booster doses in a highly vaccinated population with minimal natural exposure to COVID-19 Open
Population-level waning of protection following immunising exposures is an important determinant of susceptibility to COVID-19 outbreaks. This work outlines an individual-based model (IBM) for the transmission and clinical impact of SARS-C…
View article: Defining the correlates of lymphopenia and independent predictors of poor clinical outcome in adults hospitalized with COVID-19 in Australia
Defining the correlates of lymphopenia and independent predictors of poor clinical outcome in adults hospitalized with COVID-19 in Australia Open
View article: Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: a systematic review and meta-analysis
Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: a systematic review and meta-analysis Open
Australian Government Department of Health, Medical Research Future Fund, and Australian National Health and Medical Research Council.
View article: Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates
Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates Open
The ongoing evolution of the SARS-CoV-2 virus has led to a move to update vaccine antigens in 2022 and 2023. These updated antigens were chosen and approved based on in vitro neutralisation titres against recent SARS-CoV-2 variants. Howeve…
View article: Preferential selection of viral escape mutants by CD8+ T cell ‘sieving’ of SIV reactivation from latency
Preferential selection of viral escape mutants by CD8+ T cell ‘sieving’ of SIV reactivation from latency Open
HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8 + T cells may act to prevent early events in viral reactivation. However, the presence of viral immune escape mutations may limit the effect of CD8 +…
View article: Cost-effective boosting allocations in the post-Omicron era of COVID-19 management
Cost-effective boosting allocations in the post-Omicron era of COVID-19 management Open
Background Following widespread exposure to Omicron variants, COVID-19 has transitioned to endemic cir- culation. Populations now have diverse infection and vaccination histories, resulting in heterogeneous immune landscapes. Careful consi…
View article: Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis Open
View article: Individual variation in vaccine immune response can produce bimodal distributions of protection
Individual variation in vaccine immune response can produce bimodal distributions of protection Open
The ability for vaccines to protect against infectious diseases varies among individuals, but computational models employed to inform policy typically do not account for this variation. Here we examine this issue: we implement a model of v…
View article: Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections
Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections Open
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plasma antib…
View article: Monoclonal antibody levels and protection from COVID-19
Monoclonal antibody levels and protection from COVID-19 Open
View article: Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dyna…
View article: Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis
Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis Open
Summary Background Surrogates of antiviral efficacy are needed for COVID-19. We investigated the relationship between the virological effect of treatment and clinical efficacy as measured by progression to severe disease in unvaccinated ou…
View article: Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough
Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough Open
Summary Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plas…
View article: Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis
Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis Open
Vaccine protection from symptomatic SARS-CoV-2 infection has been shown to be strongly correlated with neutralising antibody titres; however, this has not yet been demonstrated for severe COVID-19. To explore whether this relationship also…
View article: Predicting the efficacy of variant-modified COVID-19 vaccine boosters
Predicting the efficacy of variant-modified COVID-19 vaccine boosters Open
View article: Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection
Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection Open
SARS-CoV-2 breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific hum…
View article: Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data
Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data Open
Background In malaria endemic regions, transmission of Plasmodium falciparum parasites is often seasonal with very low transmission during the dry season and high transmission in the wet season. Parasites survive the dry season within some…
View article: Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection Open
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms…
View article: Individual Variation in Vaccine Immune Response Can Produce Bimodal Distributions of Protection
Individual Variation in Vaccine Immune Response Can Produce Bimodal Distributions of Protection Open
View article: Population heterogeneity in Plasmodium vivax relapse risk
Population heterogeneity in Plasmodium vivax relapse risk Open
A key characteristic of Plasmodium vivax parasites is their ability to adopt a latent liver-stage form called hypnozoites, able to cause relapse of infection months or years after a primary infection. Relapses of infection through hypnozoi…