Deborah Decrop
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View article: Digital Microfluidics for Single Bacteria Capture and Selective Retrieval Using Optical Tweezers
Digital Microfluidics for Single Bacteria Capture and Selective Retrieval Using Optical Tweezers Open
When screening microbial populations or consortia for interesting cells, their selective retrieval for further study can be of great interest. To this end, traditional fluorescence activated cell sorting (FACS) and optical tweezers (OT) en…
View article: Controlling the Bioreceptor Spatial Distribution at the Nanoscale for Single Molecule Counting in Microwell Arrays
Controlling the Bioreceptor Spatial Distribution at the Nanoscale for Single Molecule Counting in Microwell Arrays Open
The ability to detect low concentrations of protein biomarkers is crucial for the early-stage detection of many diseases and therefore indispensable for improving diagnostic devices for healthcare. Here, we demonstrate that by integrating …
View article: Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants
Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants Open
This paper investigates the effects on the blood compatibility of surface nanostructuring of Parylene-C coating. The proposed technique, based on the consecutive use of O2 and SF6 plasma, alters the surface roughness and enhances the intri…
View article: Target Confinement in Small Reaction Volumes Using Microfluidic Technologies: A Smart Approach for Single-Entity Detection and Analysis
Target Confinement in Small Reaction Volumes Using Microfluidic Technologies: A Smart Approach for Single-Entity Detection and Analysis Open
Over the last decades, the study of cells, nucleic acid molecules, and proteins has evolved from ensemble measurements to so-called single-entity studies. The latter offers huge benefits, not only as biological research tools to examine he…
View article: Single-Step Imprinting of Femtoliter Microwell Arrays Allows Digital Bioassays with Attomolar Limit of Detection
Single-Step Imprinting of Femtoliter Microwell Arrays Allows Digital Bioassays with Attomolar Limit of Detection Open
Bead-based microwell array technology is growing as an ultrasensitive analysis tool as exemplified by the successful commercial applications from Illumina and Quanterix for nucleic acid analysis and ultrasensitive protein measurements, res…
View article: Bioassay Development for Ultrasensitive Detection of Influenza A Nucleoprotein Using Digital ELISA
Bioassay Development for Ultrasensitive Detection of Influenza A Nucleoprotein Using Digital ELISA Open
Flu is caused by the influenza virus that, due to mutations, keeps our body vulnerable for infections, making early diagnosis essential. Although immuno-based diagnostic tests are available, they have low sensitivity and reproducibility. I…
View article: Optical Manipulation of Single Magnetic Beads in a Microwell Array on a Digital Microfluidic Chip
Optical Manipulation of Single Magnetic Beads in a Microwell Array on a Digital Microfluidic Chip Open
The detection of single molecules in magnetic microbead microwell array formats revolutionized the development of digital bioassays. However, retrieval of individual magnetic beads from these arrays has not been realized until now despite …