Deborah E. Malden
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View article: Comparative risk of post-acute sequelae following SARS-CoV-2 or influenza virus infection: A retrospective cohort study among United States adults
Comparative risk of post-acute sequelae following SARS-CoV-2 or influenza virus infection: A retrospective cohort study among United States adults Open
Background Post-acute sequelae (PAS) of SARS-CoV-2 infection are well documented. However, it remains unclear whether such long-term health effects are unique to COVID-19, or also occur following other viral respiratory infections. Methods…
View article: Polygenic prediction of body mass index and obesity through the life course and across ancestries
Polygenic prediction of body mass index and obesity through the life course and across ancestries Open
View article: Long-term risk of post-acute sequelae among adults following SARS-CoV-2 or influenza virus infection: a retrospective cohort study in a large, integrated healthcare system
Long-term risk of post-acute sequelae among adults following SARS-CoV-2 or influenza virus infection: a retrospective cohort study in a large, integrated healthcare system Open
Background The comparative risk of post-acute sequelae (PAS) associated with SARS-CoV-2 and influenza virus infection remains unclear. Methods We undertook a retrospective cohort study within the Kaiser Permanente Southern California healt…
View article: A Public health wound: health and work among children engaged in the worst forms of child labour in the informal sector in Dhaka, Bangladesh: a retrospective analysis of Médecins Sans Frontières occupational health data from 2014 to 2023
A Public health wound: health and work among children engaged in the worst forms of child labour in the informal sector in Dhaka, Bangladesh: a retrospective analysis of Médecins Sans Frontières occupational health data from 2014 to 2023 Open
View article: Age Bias, Missing Data, and Declining Response Rates in the National Youth Risk Behavior Survey and Their Influence on Estimates of Trends in Adolescent Sexual Experience, 2011-2023
Age Bias, Missing Data, and Declining Response Rates in the National Youth Risk Behavior Survey and Their Influence on Estimates of Trends in Adolescent Sexual Experience, 2011-2023 Open
Introduction The national Youth Risk Behavior Survey (YRBS) has experienced considerable declines in response rates, increases in missing data on sexual experience, and shifts in data collection – all of which raise questions about bias in…
View article: Declines in HIV Incidence and Prevalence and Predictors Among Adolescents and Young Adults: An Observational Cohort Study, Rakai, Uganda, 2005-2020
Declines in HIV Incidence and Prevalence and Predictors Among Adolescents and Young Adults: An Observational Cohort Study, Rakai, Uganda, 2005-2020 Open
Background HIV acquisition among adolescents and young adults (AYA, 15-24 years) is influenced by individual factors, community factors, and public policies and programs. We explored the association of HIV incidence and prevalence with the…
View article: A Public health wound: health and work among children engaged in worst forms of child labour in the informal sector in Dhaka, Bangladesh: a retrospective analysis of Médecins Sans Frontières Occupational health data from 2014 to 2023.
A Public health wound: health and work among children engaged in worst forms of child labour in the informal sector in Dhaka, Bangladesh: a retrospective analysis of Médecins Sans Frontières Occupational health data from 2014 to 2023. Open
Background: Bangladesh has the second highest burden of child labour in South Asia. The informal sector employs most of the children however, evidence and data on health including injuries and place of work for children are limited. As the…
View article: A Texting- and Internet-Based Self-Reporting System for Enhanced Vaccine Safety Surveillance With Insights From a Large Integrated Health Care System in the United States: Prospective Cohort Study
A Texting- and Internet-Based Self-Reporting System for Enhanced Vaccine Safety Surveillance With Insights From a Large Integrated Health Care System in the United States: Prospective Cohort Study Open
Background SMS text messaging- and internet-based self-reporting systems can supplement existing vaccine safety surveillance systems, but real-world participation patterns have not been assessed at scale. Objective This study aimed to desc…
View article: Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection
Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection Open
COVID-19 vaccinations protect against severe illness and death, but associations with post-COVID conditions (PCC) are less clear. We aimed to evaluate the association between prior COVID-19 vaccination and new-onset PCC among individuals w…
View article: Immune escape and attenuated severity associated with the SARS-CoV-2 BA.2.86/JN.1 lineage
Immune escape and attenuated severity associated with the SARS-CoV-2 BA.2.86/JN.1 lineage Open
The SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023-24. However, the increase in infections was not accompanied by increases in COVID-19 hospitalizations and …
View article: Predictors of nirmatrelvir–ritonavir receipt among COVID-19 patients in a large US health system
Predictors of nirmatrelvir–ritonavir receipt among COVID-19 patients in a large US health system Open
A clear understanding of real-world uptake of nirmatrelvir–ritonavir for treatment of SARS-CoV-2 can inform treatment allocation strategies and improve interpretation of effectiveness studies. We used data from a large US healthcare system…
View article: Natural Language Processing for Improved Characterization of COVID-19 Symptoms: Observational Study of 350,000 Patients in a Large Integrated Health Care System
Natural Language Processing for Improved Characterization of COVID-19 Symptoms: Observational Study of 350,000 Patients in a Large Integrated Health Care System Open
Background Natural language processing (NLP) of unstructured text from electronic medical records (EMR) can improve the characterization of COVID-19 signs and symptoms, but large-scale studies demonstrating the real-world application and v…
View article: Reactions following Pfizer-BioNTech COVID-19 mRNA vaccination and related healthcare encounters among 7,077 children aged 5-11 years within an integrated healthcare system
Reactions following Pfizer-BioNTech COVID-19 mRNA vaccination and related healthcare encounters among 7,077 children aged 5-11 years within an integrated healthcare system Open
While post-vaccination reactions to the Pfizer-BioNTech COVID-19 mRNA vaccine were common in children aged 5-11 years, our data showed that in most cases they were transient and did not require medical care.
View article: A saturated map of common genetic variants associated with human height
A saturated map of common genetic variants associated with human height Open
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes 1 . Here, using dat…
View article: Effectiveness of nirmatrelvir-ritonavir against hospital admission or death: a cohort study in a large US healthcare system
Effectiveness of nirmatrelvir-ritonavir against hospital admission or death: a cohort study in a large US healthcare system Open
Background In the United States, oral nirmatrelvir-ritonavir (Paxlovid™) is authorized for use among patients aged ≥12 years with mild-to-moderate SARS-CoV-2 infection who are at risk for progression to severe COVID-19, including hospitali…
View article: Health Care Utilization in the 6 Months Following SARS-CoV-2 Infection
Health Care Utilization in the 6 Months Following SARS-CoV-2 Infection Open
This cohort study documented an excess health care burden of PCC in the 6 months after the acute stage of infection. As health care systems evolve during a highly dynamic and ongoing global pandemic, these data provide valuable evidence to…
View article: Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment — California, December 2021–May 2022
Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment — California, December 2021–May 2022 Open
Nirmatrelvir/ritonavir (Paxlovid) is a combination protease inhibitor that blocks replication of SARS-CoV-2 (the virus that causes COVID-19) and has been shown to reduce the risk for hospitalization and death among patients with mild to mo…
View article: Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) outbreak investigation in a hospital emergency department—California, December 2020–January 2021
Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) outbreak investigation in a hospital emergency department—California, December 2020–January 2021 Open
We describe a large outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) involving an acute-care hospital emergency department during December 2020 and January 2021, in which 27 healthcare personnel worked while infectious…
View article: A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries
A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries Open
Common SNPs are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here we show, using GWAS data from 5.4 million indiv…
View article: Natural Language Processing for Improved COVID-19 Characterization: Evidence from More than 350,000 Patients in a Large Integrated Health Care System
Natural Language Processing for Improved COVID-19 Characterization: Evidence from More than 350,000 Patients in a Large Integrated Health Care System Open
View article: Distribution of SARS-CoV-2 Variants in a Large Integrated Health Care System — California, March–July 2021
Distribution of SARS-CoV-2 Variants in a Large Integrated Health Care System — California, March–July 2021 Open
Data from observational studies demonstrate that variants of SARS-CoV-2, the virus that causes COVID-19, have evolved rapidly across many countries (1,2). The SARS-CoV-2 B.1.617.2 (Delta) variant of concern is more transmissible than previ…
View article: Accessibility, inclusivity, and implementation of COVID-19 clinical management guidelines early in the pandemic: a global survey
Accessibility, inclusivity, and implementation of COVID-19 clinical management guidelines early in the pandemic: a global survey Open
Background With a rapidly changing evidence base, high-quality clinical management guidelines (CMGs) are key tools for aiding clinical decision making and increasing access to best available evidence-based care. A rapid review of COVID-19 …
View article: Clinicians' views on COVID-19 clinical management guidelines - availability, scope, and quality
Clinicians' views on COVID-19 clinical management guidelines - availability, scope, and quality Open
The aim of this survey is to assess access to and implementation of evidence based clinical management guidelines that include recommendations on empirical treatment (medications) and standard care (oxygen, fluids etc.) for patients with C…
View article: Circulating asymmetric dimethylarginine and cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
Circulating asymmetric dimethylarginine and cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort Open
Background The underlying mechanisms leading to dementia and Alzheimer's disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but populati…
View article: Adiposity and Coronary Heart Disease in the UK Biobank: A Prospective Cohort study of 500 000 adults
Adiposity and Coronary Heart Disease in the UK Biobank: A Prospective Cohort study of 500 000 adults Open
Background Excess adiposity is a known risk factor for coronary heart disease (CHD). However, the underlying mechanisms have not been fully elucidated, and the relevance of different adiposity phenotypes remains unclear. \n\nMeth…
View article: P4209Coronary heart disease in relation to general and central adiposity in the UK Biobank: A cohort study of 500 000 men and women
P4209Coronary heart disease in relation to general and central adiposity in the UK Biobank: A cohort study of 500 000 men and women Open