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Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF Open

Yumeng Jia, W. D. Niu, Lu Liu, Qun Zhang, Dongmei Li , et al. · 2025

Background: Disrupted cardiomyocyte energy metabolism is a hallmark of heart failure with preserved ejection fraction (HFpEF). Succinate, a key intermediate of the tricarboxylic acid cycle, is markedly decreased in HFpEF myocardium. Beyond…

Evaluating Large Language Models in Ptosis-Related inquiries: A Cross-Lingual Study Open

Luyuan Niu, Wei Li, Bing Qin, Tao Chen, Li Dong , et al. · 2025

Computer science Medicine

This study bridges artificial intelligence (AI) advancements with clinical practice by demonstrating how optimized LLMs can enhance patient education and cross-linguistic clinician support tools in ptosis-related inquiries.

Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate-risk acute myeloid leukemia Open

Mingyang Wang, Shulian Chen, Qiuqiu Zhang, Linyu Yuan, Xue Wang , et al. · 2025

Medicine Biology Psychology

Introduction Hematopoietic stem cell transplantation (HSCT) and chemotherapy are considered potentially curative options for post-remission therapy in acute myeloid leukemia (AML). However, the comparative effectiveness of these approaches…

Adjusting for Glycemic Control in Assessing the Relationship Between Age-Related Macular Degeneration and Diabetic Retinopathy Open

Michael Wolek, Brian M. Wollocko, Dongmei Li, Jahnvi Bansal, Nimra Ghani , et al. · 2024

Medicine

Purpose Studies regarding the relationship between age-related macular degeneration (AMD) and diabetic retinopathy (DR) conflict: while some support that AMD is protective against DR, others find the opposite. The mechanism by which AMD ma…

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