Deborah Stroka
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View article: Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state Open
The contribution of chemotherapy-induced tissue injury to individual susceptibility to metastasis remains largely unexplored. We report that chemotherapy indirectly prevents colorectal cancer (CRC) liver metastases by inducing a lasting sy…
View article: Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2
Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2 Open
Noncoding RNAs play pivotal roles in tumorigenesis and cancer progression. Recent evidence has identified vault RNAs (vtRNAs) as critical regulators of cellular homeostasis. The human genome encodes four vtRNA paralogs, which are different…
View article: Rho-kinase inhibition reduces subretinal fibrosis
Rho-kinase inhibition reduces subretinal fibrosis Open
Subretinal fibrosis, a consequence of choroidal neovascularization (CNV) in age-related macular degeneration (AMD), leads to irreversible vision loss due to excessive accumulation of extracellular matrix (ECM) proteins and fibrotic scarrin…
View article: Plasma Fibronectin Released by Peritoneal Macrophages Promotes Remote Skin Wound Healing
Plasma Fibronectin Released by Peritoneal Macrophages Promotes Remote Skin Wound Healing Open
Background Large peritoneal macrophages (LPMs), located in the peritoneal cavity, are essential for local tissue repair. However, their contribution to tissue repair at distant sites remains unclear. Aims This study investigates the role o…
View article: In vivo DNA replication dynamics unveil aging-dependent replication stress
In vivo DNA replication dynamics unveil aging-dependent replication stress Open
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after pa…
View article: Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis
Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Author response: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Author response: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Spatial Transcriptomics Reveals Interaction of Injury-Derived Osteopontin with Mesothelial Cells in Serosal Scarring
Spatial Transcriptomics Reveals Interaction of Injury-Derived Osteopontin with Mesothelial Cells in Serosal Scarring Open
Background Abdominal surgeries are often live-saving procedures. However, surgical interventions in the peritoneal cavity can cause the formation of post-surgical adhesions. These irreversible scar bands can trigger severe complications, s…
View article: Selective Inhibition of Hepatocyte Claudin-3 Ameliorates Fibrotic and Cholestatic Liver Damage by Enhancing Bicarbonate Secretion and Bile Dynamics.
Selective Inhibition of Hepatocyte Claudin-3 Ameliorates Fibrotic and Cholestatic Liver Damage by Enhancing Bicarbonate Secretion and Bile Dynamics. Open
Background Cholestatic-fibrotic liver diseases have a high unmet medical need. Tight junctions, which maintain the blood-biliary-barrier in the liver, have important biological functions that impact cholestatic diseases. A main component o…
View article: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis
Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Reviewer #2 (Public Review): Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Reviewer #2 (Public Review): Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Reviewer #1 (Public Review): Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Reviewer #1 (Public Review): Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Author response: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Author response: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Joint Public Review: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Joint Public Review: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Author response: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Author response: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis Open
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to …
View article: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…
View article: Germline <i>cis</i> variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ( <i>DPYD</i> )
Germline <i>cis</i> variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ( <i>DPYD</i> ) Open
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the preci…