Debra Yee
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View article: Oropouche virus efficiently replicates and is immunostimulatory in vivo in nonhuman primate species
Oropouche virus efficiently replicates and is immunostimulatory in vivo in nonhuman primate species Open
An Oropouche virus (OROV) outbreak occurred in South America in 2024. The pathogenic potential and host immunological response of this emerging virus are largely unknown, as animal models have been poorly explored. We infected nonhuman pri…
View article: SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier
SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier Open
SARS-CoV-2 infects via the respiratory tract, but COVID-19 includes an array of non-respiratory symptoms, among them gastrointestinal (GI) manifestations such as vomiting and diarrhea. Here we investigated the GI pathology of SARS-CoV-2 in…
View article: Recombinant OC43 SARS-CoV-2 spike replacement virus: An improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays
Recombinant OC43 SARS-CoV-2 spike replacement virus: An improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays Open
We generated a replication-competent OC43 human seasonal coronavirus (CoV) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike in place of the native spike (rOC43-CoV2 S). This virus is highly attenuated relat…
View article: Selective IgA2 deficiency in a patient with small intestinal Crohn’s disease
Selective IgA2 deficiency in a patient with small intestinal Crohn’s disease Open
Selective IgA 2 deficiency in a patient with small intestinal Crohn's disease
View article: Critical COVID-19 disease explained by type I interferon autoantibodies found in patients within the Military Health System
Critical COVID-19 disease explained by type I interferon autoantibodies found in patients within the Military Health System Open
Neutralizing auto-antibodies (auto-Abs) that target type I interferons (IFN), a group of cytokines that induce innate immune responses upon viral infection, are found within approximately 10–20% of patients with critical COVID-19. We sough…
View article: Hyper-IgE and Carcinoma in CADINS Disease
Hyper-IgE and Carcinoma in CADINS Disease Open
Background Atopic dermatitis (AD) affects up to 25% of children and 10% of adults in Western countries. When severe or recurrent infections and exceedingly elevated serum IgE levels occur in AD patients, an inborn error of immunity (IEI) m…
View article: Restimulation-Induced Cell Death (RICD): Methods for Modeling, Investigating, and Quantifying RICD Sensitivity in Primary Human T Cells via Flow Cytometric Analysis
Restimulation-Induced Cell Death (RICD): Methods for Modeling, Investigating, and Quantifying RICD Sensitivity in Primary Human T Cells via Flow Cytometric Analysis Open
When the body mounts an immune response against a foreign pathogen, the adaptive arm of the immune system relies upon clonal expansion of antigen-specific T cell populations to exercise acquired effector and cytotoxic functions to clear it…
View article: 450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient
450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient Open
Background Approximately 10-20% of patients with critical COVID-19 harbor neutralizing autoantibodies (auto-Abs) that target type I interferons (IFN), a family of cytokines that induce critical innate immune defense mechanisms upon viral i…
View article: The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid–liquid phase separation
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid–liquid phase separation Open
Myxoid liposarcoma is caused by a chromosomal translocation resulting in a fusion protein comprised of the N terminus of FUS (fused in sarcoma) and the full-length transcription factor CHOP (CCAAT/enhancer-binding protein homologous protei…
View article: The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation Open
Myxoid liposarcoma is caused by a chromosomal translocation resulting in a fusion protein comprised of the N-terminus of FUS (fused in sarcoma) and the full-length transcription factor CHOP (CCAAT/Enhancer Binding Protein Homologous Protei…
View article: The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions
The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions Open
We characterized novel phosphorylation patterns in FUS’s prion-like domain when FUS was cytoplasmic due to disease mutation or cellular stress. Phosphomimetic substitutions at kinase sites suggest moderate phosphorylation of FUS’s prion-li…
View article: Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms
Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms Open
Many proteins involved in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS) are remarkably similar to proteins that form prions in the yeast Saccharomyces cerevisiae. These ALS-associated proteins are not orthologs of yeast …
View article: The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS
The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS Open
Subcellular mislocalization and aggregation of the human FUS protein occurs in neurons of patients with subtypes of amyotrophic lateral sclerosis and frontotemporal dementia. FUS is one of several RNA-binding proteins that can functionally…