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View article: DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway
DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway Open
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View article: Transcriptome Analysis of Developmental Gene Expression in Thesium chinense Turcz
Transcriptome Analysis of Developmental Gene Expression in Thesium chinense Turcz Open
Thesium chinense Turcz. (T. chinense), a perennial herb in the Santalaceae family, exhibits potent antibacterial and anti-inflammatory properties. Transcriptome sequencing was performed on one- and two-year-old T. chinense plants across se…
View article: Immunization of pigs with Actinobacillus pleuropneumonia live attenuated (gene-deleted) vaccine HB04M intramuscularly or intranasally exhibits remarkably rapid protection against heterologous strain challenge.
Immunization of pigs with Actinobacillus pleuropneumonia live attenuated (gene-deleted) vaccine HB04M intramuscularly or intranasally exhibits remarkably rapid protection against heterologous strain challenge. Open
Actinobacillus pleuropneumonia (APP) is the etiological agent of porcine pleuropneumonia, characterized by acute hemorrhagic fibrinous pleuropneumonia and chronic fibrinous necrotizing pleuropneumonia. The acute manifestation of APP is mar…
View article: T-Cell Wars, A New Hope: Targeting Bcl6-Expressing T Cells in T1D
T-Cell Wars, A New Hope: Targeting Bcl6-Expressing T Cells in T1D Open
View article: Targeting inflammation with chimeric antigen receptor macrophages using a signal switch
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch Open
View article: Inferring gene regulatory networks by hypergraph generative model
Inferring gene regulatory networks by hypergraph generative model Open
We present hypergraph variational autoencoder (HyperG-VAE), a Bayesian deep generative model that leverages hypergraph representation to model single-cell RNA sequencing (scRNA-seq) data. The model features a cell encoder with a structural…
View article: The landscape of research on ferroptosis under hypoxic conditions: a bibliometric analysis
The landscape of research on ferroptosis under hypoxic conditions: a bibliometric analysis Open
Background Ferroptosis is a newly identified type of iron-dependent cell death that characterized by an increase in intracellular iron ions, which disrupt the balance of the cellular lipid peroxidation system, causing lipid peroxidation an…
View article: AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression
AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression Open
The constrained cross-talk between myeloid cells and T cells in the tumor immune microenvironment (TIME) restricts cancer immunotherapy efficacy, whereas the underlying mechanism remains elusive. Parkin, an E3 ubiquitin ligase renowned for…
View article: Balancing the Localization and Internationalization of Higher Education in the Context of Globalization
Balancing the Localization and Internationalization of Higher Education in the Context of Globalization Open
In the tendency of globalization and internationalization, higher education is facing unprecedented opportunities and challenges. On one hand, the internationalization trend continuously prompts universities to expand international coopera…
View article: Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps
Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps Open
Sophisticated interactions between stromal and immune cells play crucial roles in various biological and pathological processes. In chronic rhinosinusitis with nasal polyps (CRSwNP), the upper airway inflammation in many patients is driven…
View article: Follicular T cells and the control of IgE responses
Follicular T cells and the control of IgE responses Open
Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) ce…
View article: IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection
IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection Open
Summary Cytotoxic CD8+ T cells, essential in combating viral infections and cancer, become dysfunctional from prolonged antigen exposure. Precursors of exhausted T (TPEX) cells are pivotal in sustaining immune responses in chronic diseases…
View article: IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection
IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection Open
Summary Cytotoxic CD8+ T cells, essential in combating viral infections and cancer, become dysfunctional from prolonged antigen exposure. Precursors of exhausted T (TPEX) cells are pivotal in sustaining immune responses in chronic diseases…
View article: Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis Open
View article: IL-2 enhances effector function but suppresses follicular localization of CD8 <sup>+</sup> T cells in chronic infection
IL-2 enhances effector function but suppresses follicular localization of CD8 <sup>+</sup> T cells in chronic infection Open
Summary Cytotoxic CD8 + T cells, essential in combating viral infections and cancer, become dysfunctional from prolonged antigen exposure. Precursors of exhausted T (T PEX ) cells are pivotal in sustaining immune responses in chronic disea…
View article: Inferring gene regulatory networks by hypergraph variational autoencoder
Inferring gene regulatory networks by hypergraph variational autoencoder Open
In constructing Gene Regulatory Networks (GRNs), it is crucial to consider cellular heterogeneity and differential gene regulatory modules. However, traditional methods have predominantly focused on cellular heterogeneity, approaching the …
View article: International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis Open
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell …
View article: Endogenous retrovirus promotes the aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway
Endogenous retrovirus promotes the aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway Open
The dysregulated differentiation of T lymphocyte play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Here, we showed that many transcripts derived from human endogenous retroviru…
View article: Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization Open
The COVID-19 pandemic has fostered major advances in vaccination technologies1-4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration4-6. …
View article: Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization Open
The coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs for vaccines that induce mucosal immune responses and single-dose, noninvasive administration. Here, we develop an in…
View article: Using Adamic-Adar Index Algorithm to Predict Volunteer Collaboration: Less is More
Using Adamic-Adar Index Algorithm to Predict Volunteer Collaboration: Less is More Open
Social networks exhibit a complex graph-like structure due to the uncertainty surrounding potential collaborations among participants. Machine learning algorithms possess generic outstanding performance in multiple real-world prediction ta…
View article: Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives
Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives Open
Vaccination stands as the cornerstone in the battle against infectious diseases, and its efficacy hinges on several host-related factors like genetics, age, and metabolic status. Vulnerable populations, such as malnourished individuals, th…
View article: Proinflammatory impact of putative viral-specific CD8+ T cells infiltrating new-onset seropositive rheumatoid arthritis synovium
Proinflammatory impact of putative viral-specific CD8+ T cells infiltrating new-onset seropositive rheumatoid arthritis synovium Open
New-onset HLA-DR-associated anti-citrullinated protein autoantibody (ACPA)+ rheumatoid arthritis (RA) synovial tissue (ST) contains highly-expanded TCR-αβ clonotypes, some viral-antigen-reactive. However, it is unknown how viral…
View article: T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance
T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance Open
A defining feature of successful vaccination is the ability to induce long-lived antigen-specific memory cells. T follicular helper (Tfh) cells specialize in providing help to B cells in mounting protective humoral immunity in infection an…
View article: Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation
Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation Open
View article: Autoimmune uveitis in Behçet's disease and Vogt‐Koyanagi‐Harada disease differ in tissue immune infiltration and T cell clonality
Autoimmune uveitis in Behçet's disease and Vogt‐Koyanagi‐Harada disease differ in tissue immune infiltration and T cell clonality Open
Objectives Non‐infectious uveitis is often secondary to systemic autoimmune diseases, with Behçet's disease (BD) and Vogt‐Koyanagi‐Harada disease (VKHD) as the two most common causes. Uveitis in BD and VKHD can show similar clinical manife…
View article: Author response: T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance
Author response: T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance Open
Article Figures and data Abstract Editor's evaluation Main text Data availability References Decision letter Author response Article and author information Metrics Abstract A defining feature of successful vaccination is the ability to ind…
View article: Inhalable SARS-CoV-2 vaccines for single-dose dry-powder aerosol immunization and orchestrated mucosal/systemic immune responses
Inhalable SARS-CoV-2 vaccines for single-dose dry-powder aerosol immunization and orchestrated mucosal/systemic immune responses Open
The ongoing coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs of mucosal immune responses and single-dose, non-invasive administration. Here, we develop a SARS-CoV-2 vacci…
View article: Single-cell RNA sequencing reveals the distinctive roles of CD4<sup>+</sup>and CD8<sup>+</sup>T cells in autoimmune uveitis
Single-cell RNA sequencing reveals the distinctive roles of CD4<sup>+</sup>and CD8<sup>+</sup>T cells in autoimmune uveitis Open
Uveitis is a common cause of blindness and classified as infectious or non-infectious types. Non-infectious uveitis is often secondary to systemic autoimmune diseases, with Behçet’s disease (BD) and Vogt-Koyanagi-Harada disease (VKHD) as t…
View article: LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus
LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus Open
Background The aberrant differentiation of T follicular helper (Tfh) cells plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of regulating Tfh cells differentiation remains unclear. L…