Declan A. Gray
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View article: Antibiotic resistance selection and deselection in municipal wastewater from 47 countries
Antibiotic resistance selection and deselection in municipal wastewater from 47 countries Open
Wastewaters are plausible arenas for antibiotic resistance evolution and transmission, yet selection for resistance by municipal wastewater has rarely been empirically demonstrated. Here, we experimentally investigate the potential of untr…
View article: Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS
Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS Open
The bactericidal activity of several antibiotics partially relies on the production of reactive oxygen species (ROS), which is generally linked to enhanced respiration and requires the Fenton reaction. Bacterial persister cells, an importa…
View article: Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS
Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS Open
The bactericidal activity of several commonly used antibiotics have been shown to partially rely on the production of reactive oxygen species (ROS). Bacterial persister cells, an important cause of recurring infections, are tolerant to the…
View article: Insights into glycan import by a prominent gut symbiont
Insights into glycan import by a prominent gut symbiont Open
In Bacteroidetes, one of the dominant phyla of the mammalian gut, active uptake of large nutrients across the outer membrane is mediated by SusCD protein complexes via a “pedal bin” transport mechanism. However, many features of SusCD func…
View article: Multitarget Approaches against Multiresistant Superbugs
Multitarget Approaches against Multiresistant Superbugs Open
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery to keep pace. Often, resistance against a new drug develops even before it reaches the market. This continued resistance crisis…
View article: More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin
More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin Open
Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections, bacteremia, and right-sided endocarditis caused …
View article: Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes Open
The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial compounds. Commonly, although not exclusively, these compounds unfold their antimicrobial activity by disrupting the essential barrier function of the cell m…