Declan R. Creamer
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View article: Genomic foundation models reveal RNA-binding proteins regulating translation and mRNA degradation during <i>Drosophila</i> development
Genomic foundation models reveal RNA-binding proteins regulating translation and mRNA degradation during <i>Drosophila</i> development Open
Background The regulation of mRNA decay and translation is crucial for cellular function and development; however, the complex interplay of RNA-binding proteins (RBPs) regulating these processes remains incompletely understood. Recent adva…
View article: Isoform-specific sequestration of protein kinase A fine-tunes intracellular signaling during heat stress
Isoform-specific sequestration of protein kinase A fine-tunes intracellular signaling during heat stress Open
View article: Sequestrase chaperones protect against oxidative stress-induced protein aggregation and [PSI+] prion formation
Sequestrase chaperones protect against oxidative stress-induced protein aggregation and [PSI+] prion formation Open
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they can be sequestered to specific sites within cells to prevent the poten…
View article: Sequestrase chaperones protect against oxidative stress-induced protein aggregation and [<i>PSI<sup>+</sup></i>] prion formation
Sequestrase chaperones protect against oxidative stress-induced protein aggregation and [<i>PSI<sup>+</sup></i>] prion formation Open
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they can be sequestered to specific sites within cells to prevent the poten…
View article: AlacatDesigner─Computational Design of Peptide Concatamers for Protein Quantitation
AlacatDesigner─Computational Design of Peptide Concatamers for Protein Quantitation Open
Protein quantitation via mass spectrometry relies on peptide proxies for the parent protein from which abundances are estimated. Owing to the variability in signal from individual peptides, accurate absolute quantitation usually relies on …
View article: The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved
The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved Open
The chaperone-mediated sequestration of misfolded proteins into inclusions is a pivotal cellular strategy to maintain proteostasis in Saccharomyces cerevisiae, executed by small heat shock proteins (sHsps) Hsp42 and Btn2. Direct homologs o…
View article: Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?
Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions? Open
Eukaryotic cells have developed a complex circuitry of signalling molecules which monitor changes in their intra- and extracellular environments. One of the most widely studied signalling pathways is the highly conserved cyclic AMP (cAMP)/…
View article: Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway
Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway Open