Dee Pei
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View article: Explainable Machine Learning Models for Predicting FEV1 in Non-Smoking Taiwanese Men Aged 45–55 Years
Explainable Machine Learning Models for Predicting FEV1 in Non-Smoking Taiwanese Men Aged 45–55 Years Open
Background: Traditional regression explains only part of the variation in forced expiratory volume in one second (FEV1). Machine learning (ML) methods may capture nonlinear patterns beyond linear assumptions. Methods: We analyzed 23,943 no…
View article: Using Machine Learning to Detect Factors That Affect Homocysteine in Healthy Elderly Taiwanese Men
Using Machine Learning to Detect Factors That Affect Homocysteine in Healthy Elderly Taiwanese Men Open
Background: Homocysteine (Hcy) is a sulfur-containing amino acid crucial for various physiological processes, with elevated levels linked to cardiovascular and neurological adverse conditions. Various factors contribute to high Hcy, and pa…
View article: Association between gamma-glutamyl transferase and diabetes factors among elderly nonobese individuals
Association between gamma-glutamyl transferase and diabetes factors among elderly nonobese individuals Open
Type 2 diabetes mellitus is a significant health concern among elderly individuals in Taiwan, and liver dysfunction, particularly nonalcoholic fatty liver disease, is prevalent in this population. Gamma-glutamyl transferase (γ-GT), a key e…
View article: Using machine learning to predict patients with polycystic ovary disease in Chinese women
Using machine learning to predict patients with polycystic ovary disease in Chinese women Open
Mach-L methods overtook conventional LR and age was the most significant factor, followed by TG, GPT, WBC, UA, and Plt in a cohort of Chinese women.
View article: Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging
Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging Open
The skin is subjected to various external factors that contribute to aging including oxidative stress from hydrogen peroxide (H 2 O 2 ). This study investigated the distribution of aquaporin-8 (AQP8), a protein that transports H 2 O 2 acro…
View article: Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells Open
View article: Gamma-Glutamyltransferase Is a Predictor for Future Changes of Diabetogenic Factors in Aged Chinese—A Four-Year Follow-Up Study
Gamma-Glutamyltransferase Is a Predictor for Future Changes of Diabetogenic Factors in Aged Chinese—A Four-Year Follow-Up Study Open
Glucose homeostasis in the body is determined by four diabetes factors (DFs): insulin resistance (IR), glucose effectiveness (GE), and the two phases of insulin secretion—first phase (FPIS) and second phase (SPIS). Previous research points…
View article: Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus
Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus Open
Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In…
View article: Predictors associated with prefrailty in older Taiwanese individuals with type 2 diabetes
Predictors associated with prefrailty in older Taiwanese individuals with type 2 diabetes Open
Type 2 diabetes (T2DM) is one of the most well-studied and important factors that increase the risk of prefrailty in older people in Taiwan. This study was conducted to examine whether metabolic biomarkers, lifestyle behaviors, body compos…
View article: Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population
Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population Open
Objective To evaluate the relationship between alanine transaminase (ALT) level and biphasic insulin secretion (BPIS) in healthy elderly Han Chinese individuals. Methods This cross-sectional study enrolled healthy elderly participants aged…
View article: MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer
MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer Open
Gastric cancer is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Surgery remains the first-choice treatment. Chemotherapy is considered in the middle and advanced stages, but has limited su…
View article: The Relationship between Age, BMI, Insulin Resistance and ? Cell Function in Chinese Population
The Relationship between Age, BMI, Insulin Resistance and ? Cell Function in Chinese Population Open
View article: Linear and Non-linear Associations Between Platelet Count and Metabolic Parameters in Non-Diabetic and Non-Obese Elderly
Linear and Non-linear Associations Between Platelet Count and Metabolic Parameters in Non-Diabetic and Non-Obese Elderly Open
Background: High platelet count was noted in people with metabolic syndrome. A significant association between platelet count and various metabolic parameters had also been reported. However, all the studies hypothesized that these associa…
View article: The relationships between thyroid-stimulating hormone level and insulin resistance, glucose effectiveness, first- and second-phase insulin secretion in Chinese populations
The relationships between thyroid-stimulating hormone level and insulin resistance, glucose effectiveness, first- and second-phase insulin secretion in Chinese populations Open
Increased insulin resistance (IR); decreased glucose effectiveness (GE); and both first-and second phase of insulin secretion (FPIS, SPIS) have always been important factors for the development of type 2 diabetes. Therefore, in this study,…
View article: Reduced Expression of Urokinase Plasminogen Activator in Brown Adipose Tissue of Obese Mouse Models
Reduced Expression of Urokinase Plasminogen Activator in Brown Adipose Tissue of Obese Mouse Models Open
In recent decades, the obesity epidemic has resulted in morbidity and mortality rates increasing globally. In this study, using obese mouse models, we investigated the relationship among urokinase plasminogen activator (uPA), metabolic dis…
View article: The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren
The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren Open
Irisin, a novel myokine, is believed to be the crucial factor in converting white adipose tissue to beige adipose tissue. For this paper, we studied the relationship among irisin and components of metabolic syndrome (MetS), and insulin sec…
View article: First-phase insulin secretion is positively correlated with alanine aminotransferase in young adults
First-phase insulin secretion is positively correlated with alanine aminotransferase in young adults Open
A positive correlation between ALT and FPIS exists among young adults. Moreover, this correlation was stronger for men than for women. Both the cause and the effect require further investigation.
View article: Hemogram-based decision tree for predicting the metabolic syndrome and cardiovascular diseases in the elderly
Hemogram-based decision tree for predicting the metabolic syndrome and cardiovascular diseases in the elderly Open
Summary Background This study aimed to build a hemogram-based decision tree to evaluate the association between current probability of metabolic syndrome (MetS) and prediction of future hypertension, type 2 diabetes and cardiovascular dise…
View article: Comprehensive analysis in mucin-producing urothelial-type adenocarcinoma of the prostate: case study with literature review
Comprehensive analysis in mucin-producing urothelial-type adenocarcinoma of the prostate: case study with literature review Open
It is critical to distinguish the rare neoplasm of mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) from either prostate origin or metastatic adenocarcinoma. This is mainly because they have different tumor staging, c…
View article: Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus
Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus Open
Background: The relationship between urokinase-type plasminogen activator (uPA) and the development of type 2 diabetes mellitus (T2DM) was investigated in the study by using mice and cell models, as well as patients with T2DM. Methods: In …
View article: The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese
The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese Open
Our data showed that IR, FPIS and SPIS were both positively and, GE negatively, related to the Hb in adult Chinese. For women, GE had the closest association with Hb; for men, it was IR. Both phases of insulin secretion had relatively weak…
View article: The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese
The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese Open
Objective We denote the four major factors related to the development of type 2 diabetes (T2D) as “diabetes factor” (DF); increased insulin resistance (IR); decreased glucose effectiveness (GE); and the first-and-second-phase of insulin se…
View article: Author Correction: Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study
Author Correction: Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study Open
View article: The Relationships Between Hemoglobin and Diabetes Factors (Insulin Resistance, Glucose Effectiveness, First- and Second-Phase Insulin Secretion) in Old Chinese
The Relationships Between Hemoglobin and Diabetes Factors (Insulin Resistance, Glucose Effectiveness, First- and Second-Phase Insulin Secretion) in Old Chinese Open
Summary: Background: Diabetes is characterized by increased insulin resistance (IR) and decreased insulin secretion. The roles of glucose effectiveness (GE), first- and second-phase insulin secretion (FPIS, SPIS) are often overlooked. We d…
View article: Correction: Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level
Correction: Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level Open
[This corrects the article DOI: 10.1371/journal.pone.0189115.].
View article: Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level
Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level Open
The contribution of obesity to all diabetes factors, except GE, was higher than that reported previously. BMI had the most profound effect on insulin secretion in men and on IR in women in this 60-year-old cohort, suggesting that lifestyle…
View article: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells Open
View article: Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study
Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study Open
Serum gamma-glutamyltransferase (γ-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between γ-GT and cardiometabolic dysregulation remains unclear in adolescents. We enroll…
View article: High normotension is associated with future metabolic syndrome but not cardiovascular disease
High normotension is associated with future metabolic syndrome but not cardiovascular disease Open
Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-…
View article: Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia
Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia Open