Deeksha Malhan
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View article: Biomarkers predicting the effectiveness of normobaric altitude training
Biomarkers predicting the effectiveness of normobaric altitude training Open
Purpose The aim of the present study was to identify blood-based biomarkers that could predict individual VO 2 max improvement before the start of an artificial altitude training camp. Methods In an exploratory intervention study, 15 young…
View article: Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity
Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity Open
Altitude training is a method among endurance athletes to enhance performance via hypoxia-induced adaptations. However, individual responses vary significantly, with some athletes even showing performance decrements. Iron metabolism and im…
View article: Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effects
Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effects Open
This study was funded by the Dr. Rolf Schwiete Stiftung and the MSH Medical School Hamburg, Germany. The MAMOC trial (ClinicalTrials.gov: NCT04227522) was funded by Clovis Oncology, United States.
View article: Comprehensive integrative analysis of circadian rhythms in human saliva
Comprehensive integrative analysis of circadian rhythms in human saliva Open
The circadian clock orchestrates vital physiological functions, with its dysregulation implicated in various pathologies. Assessing human clock status via the measurement of circadian rhythms is crucial for health management and disease tr…
View article: Hematological Changes in Artificial Altitude Training Affect Iron Metabolism and Immunity
Hematological Changes in Artificial Altitude Training Affect Iron Metabolism and Immunity Open
Introduction Altitude training is a method among endurance athletes to enhance performance via hypoxia-induced adaptations, However, individual responses vary significantly, with some athletes even showing performance decrements. Iron meta…
View article: A prospective study to investigate circadian rhythms as health indicator in women’s aging
A prospective study to investigate circadian rhythms as health indicator in women’s aging Open
The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for the organism’s homeostasis and is among the main characteristics of aging. As women age an…
View article: Circadian regulation in aging: Implications for spaceflight and life on earth
Circadian regulation in aging: Implications for spaceflight and life on earth Open
Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle …
View article: Landscape of Well-Coordinated Fracture Healing in a Mouse Model Using Molecular and Cellular Analysis
Landscape of Well-Coordinated Fracture Healing in a Mouse Model Using Molecular and Cellular Analysis Open
The success of fracture healing relies on overlapping but coordinated cellular and molecular events. Characterizing an outline of differential gene regulation throughout successful healing is essential for identifying crucial phase-specifi…
View article: Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells Open
The circadian clock coordinates the timing of several cellular processes including transcription, the cell cycle, and metabolism. Disruptions in the clock machinery trigger the abnormal regulation of cancer hallmarks, impair cellular homeo…
View article: Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae
Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae Open
Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these …
View article: A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes
A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes Open
Increasing evidence suggests a role for circadian dysregulation in prompting disease-related phenotypes in mammals. Cancer and neurodegenerative disorders are two aging related diseases reported to be associated with circadian disruption. …
View article: Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures—A Retrospective Cohort Study
Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures—A Retrospective Cohort Study Open
Periprosthetic femoral fracture (PFF) is a devastating complication. Here, the authors aimed to determine the influence of the timing of surgery as a risk factor for mortality and poor postoperative outcome in patients suffering from PFF. …
View article: DXA reference values of the humanoid sheep model in preclinical studies
DXA reference values of the humanoid sheep model in preclinical studies Open
Background Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not establis…
View article: Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model
Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model Open
Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteopo…
View article: Is Biofeedback through an Intra-Aural Device an Effective Method to Treat Bruxism? Case Series and Initial Experience
Is Biofeedback through an Intra-Aural Device an Effective Method to Treat Bruxism? Case Series and Initial Experience Open
Biofeedback was reported as an effective concept for bruxism treatment, through increasing patient’s awareness of the habit. During bruxing both ear canals become tighter, therefore, an in-ear device can provide biofeedback. The in-ear dev…
View article: An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling
An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling Open
Tailoring medical interventions to a particular patient and pathology has been termed personalized medicine. The outcome of cancer treatments is improved when the intervention is timed in accordance with the patient’s internal time. Yet, o…
View article: Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results
Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results Open
Hypodontia often leads to limited bone availability of the alveolar ridges. Oral rehabilitation of severe hypodontia patients is challenging. In this retrospective study, we evaluated the functional and aesthetic results after dental impla…
View article: Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases
Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases Open
Introduction . Nonunions are a challenge for orthopedic surgeons. In hypertrophic nonunions, improvement of mechanical stability usually is the satisfactory treatment, whereas in atrophic nonunions improvement of the biological environment…
View article: An Optimized Approach to Perform Bone Histomorphometry
An Optimized Approach to Perform Bone Histomorphometry Open
Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone proper…
View article: Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste
Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste Open
Background . The study aim is to avoid tooth extraction by nonsurgical treatment of periapical lesion. It assesses healing progress in response to calcium hydroxide-iodoform-silicon oil paste (CHISP). Numeric Pain Rating Scale was used to …
View article: A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model
A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model Open
BACKGROUND Osteoporosis is diagnosed by bone loss using a radiological parameter called T-score. Preclinical studies use DXA to evaluate bone status were the T-score is referenced on bone mineral density (BMD) values of the same animals be…
View article: T Lymphocytes Influence the Mineralization Process of Bone
T Lymphocytes Influence the Mineralization Process of Bone Open
Bone is a unique organ able to regenerate itself after injuries. This regeneration requires the local interplay between different biological systems such as inflammation and matrix formation. Structural reconstitution is initiated by an in…
View article: Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals
Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals Open
Bone histology of decalcified or undecalcified samples depends on the investigation. However, in research each method provides different information to answer the scientific question. Decalcification is the first step after sample fixation…
View article: In-vivo DEXA in large animal models: Does animal anatomy and positioning hold the clinical standards?
In-vivo DEXA in large animal models: Does animal anatomy and positioning hold the clinical standards? Open
Bone loss is assessed by radiological testing to diagnose systemic musculoskeletal diseases and aging. DEXA measurement is gold standard in diagnoses of bone loss in preclinical and clinical studies. Sheep model of osteoporotic was utiliz…