Deep Pooja
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View article: Influence of Probiotic Fermentation on Polysaccharides of Tamarindus indica Seeds
Influence of Probiotic Fermentation on Polysaccharides of Tamarindus indica Seeds Open
Background: Tamarind seeds are the legumes rich in protein, carbohydrates, lipids and minerals. Tamarind seed polysaccharide (TSP) is a natural polymer isolated from Tamarindus indica. It is a by-product of the tamarind pulp industry. Due …
View article: Glycyrrhizic Acid‐Based Self‐Targeted Nanomicelles for the Delivery of Gefitinib to PKCα Receptor Overexpressing Cancer Cells
Glycyrrhizic Acid‐Based Self‐Targeted Nanomicelles for the Delivery of Gefitinib to PKCα Receptor Overexpressing Cancer Cells Open
Glycyrrhizic acid (GCA), also referred to as glycyrrhizin, is a triterpene saponin produced by Glycyrrhiza glabra . GCA has many pharmacological actions, like anti‐inflammatory, antioxidant, and anti‐tumor effects. GCA is generally used as…
View article: A comprehensive study on sitagliptin in the treatment of Type-II Diabetes
A comprehensive study on sitagliptin in the treatment of Type-II Diabetes Open
Sitagliptin is an oral antihyperglycemic drug classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor; commonly used in the treatment of type 2 diabetes. It works by promoting insulin secretion and decreasing glucagon levels through the i…
View article: Designing of fucosylated dendrimers as a biocompatible carrier for the targeted delivery of chrysin to human lung cancer cells
Designing of fucosylated dendrimers as a biocompatible carrier for the targeted delivery of chrysin to human lung cancer cells Open
Dendrimers, a polymeric macromolecule, have been explored for improving the solubility of water-insoluble drugs, and PAMAM is the most explored dendrimer in nanomedicine. But amine-terminated PAMAM dendrimers confer toxicity to healthy cel…
View article: Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment
Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment Open
The third most common cancer worldwide is colon cancer (CC). Every year, there more cases are reported, yet there are not enough effective treatments. This emphasizes the need for new drug delivery strategies to increase the success rate a…
View article: Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents
Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents Open
In the last three decades, polymers have contributed significantly to the improvement of drug delivery technologies by enabling the controlled and sustained release of therapeutic agents, versatility in designing different delivery systems…
View article: Improving Anticancer Activity of Chrysin using Tumor Microenvironment pH-Responsive and Self-Assembled Nanoparticles
Improving Anticancer Activity of Chrysin using Tumor Microenvironment pH-Responsive and Self-Assembled Nanoparticles Open
Chrysin is a natural bioactive compound with potential biological activities. However, unfavorable physicochemical properties of native chrysin make it difficult to achieve good therapeutic efficacies. In this study, poly(ethylene) glycol …
View article: Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells
Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells Open
Self-assembled and pH-responsive polymeric nanomicelles were prepared for the delivery of paclitaxel to cancer cells.
View article: Amorphous nano morin outperforms native molecule in anticancer activity and oral bioavailability
Amorphous nano morin outperforms native molecule in anticancer activity and oral bioavailability Open
In the past decade, naturally occurring phytoconstituents have emerged as potential therapeutic agents and alternative to synthetic drugs. However, efficient delivery of hydrophobic phytoconstituents into the body with desired therapeutic …
View article: A nanoscale, biocompatible and amphiphilic prodrug of cabazitaxel with improved anticancer efficacy against 3D spheroids of prostate cancer cells
A nanoscale, biocompatible and amphiphilic prodrug of cabazitaxel with improved anticancer efficacy against 3D spheroids of prostate cancer cells Open
pH-reponsive and amphiphilic prodrug of cabazitaxel causes greater damages to human prostate cancer cells than free cabazitaxel.
View article: Modulating the site-specific oral delivery of sorafenib using sugar-grafted nanoparticles for hepatocellular carcinoma treatment
Modulating the site-specific oral delivery of sorafenib using sugar-grafted nanoparticles for hepatocellular carcinoma treatment Open
Globally, one in six deaths is reported due to cancer suggesting the critical need for development of advanced treatment regimens. In this study, solid lipid nanoparticles (SLN) were prepared and appended with polyethylene glycol (PEGylate…
View article: Determination of solubility, stability and degradation kinetics of morin hydrate in physiological solutions
Determination of solubility, stability and degradation kinetics of morin hydrate in physiological solutions Open
The stability of morin hydrate depends on pH, temperature, and light.
View article: Peptide Grafted and Self-Assembled Poly(γ-Glutamic Acid)-Phenylalanine Nanoparticles Targeting Camptothecin to Glioma
Peptide Grafted and Self-Assembled Poly(γ-Glutamic Acid)-Phenylalanine Nanoparticles Targeting Camptothecin to Glioma Open
Aim: To synthesize cRGDfK peptide conjugated poly(γ-glutamic acid)-phenylalanine nanoparticles to improve the therapeutic efficacy of camptothecin (CPT) against glioblastoma multiforme.\nMethods: Peptide-conjugated, drug-loaded nanoparticl…