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Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the <span>SELECT2</span> Trial Open

Scott E. Kasner, Michael T. Mullen, Michael DeGeorgia, Spiros Blackburn, Donna K. George , et al. · 2024

Objective Among patients with large vessel occlusion (LVO) and large ischemic cores, critical decisions often need to be made about decompressive hemicraniectomy (DHC) or early withdrawal of life‐sustaining therapy (WLST). In this study, w…

Abstract 089: Effect of Bridging with IV Thrombolysis Versus Direct Thrombectomy on Infarct Growth and Functional Outcomes: Sub‐Analysis from the SELECT Study Open

Mohammed Albedaiwi, Deep Pujara, A. Sarraj, Faisal Al-Shaibi, Bassam Yaghmoor , et al. · 2024

Abstract 414: Stroke Severity in patients presenting beyond 24 hours of last known well ‐ a secondary analysis of SELECT LATE cohort study Open

Amro Elrefaei, Deep Pujara, Timothy Kleinig, Abdalla E. A. Hassan, Père-Joan Cardona , et al. · 2024

Introduction Endovascular thrombectomy (EVT) is shown to be associated with better clinical outcomes even after 24 hours of stroke onset. However, how stroke severity affect this association has not been well‐established. Methods From SELE…

Cost‐Effectiveness of Endovascular Thrombectomy in Patients with Large Ischemic Stroke Open

Lan Gao, Leonid Churilov, Hannah Johns, Deep Pujara, Ameer E Hassan , et al. · 2024

Objectives Whereas highly cost‐effective and cost‐saving for patients with small infarcts, whether endovascular thrombectomy (EVT) remains cost‐effective in patients with extensive ischemic injury is uncertain. Methods We conducted a model…

Issue Information Open

Amrou Sarraj, Deep Pujara, Bruce Campbell, Matthew P. Kirschen, Ariane Lewis , et al. · 2024

OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open access by providing

Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes Open

Amrou Sarraj, Michael D. Hill, Muhammad Shazam Hussain, Michael Abraham, Santiago Ortega‐Gutiérrez , et al. · 2024

Importance Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer for endovascular thrombectomy (EVT). Objective To assess EVT treatment effects in transferred vs d…

Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles Open

Amrou Sarraj, Ameer E Hassan, Michael Abraham, Santiago Ortega‐Gutiérrez, Scott E. Kasner , et al. · 2024

Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of ischemic injury is uncertain. Objective To describe the relationship between imaging esti…

Abstract 203: Predicting Outcomes After Mechanical Thrombectomy: Early vs Delayed Neurological Improvement in the SELECT Database Open

K. Rose Duncan, Deep Pujara, Amrou Sarraj · 2023

Introduction Understanding of patient benefit and improvement following mechanical thrombectomy in ischemic stroke has made tremendous strides in recent years, however clinicians still struggle to accurately predict patient outcomes and lo…

LB-012 Incidence of intracranial hemorrhage after thrombectomy for large core infarcts: a sub analysis of the select2 trial Open

Michael Chen, Krishna C. Joshi, Bradley Kolb, Michael D. Hill, Michael Abraham , et al. · 2023

Introduction Intracranial hemorrhage (ICH) remains a major complication of endovascular thrombectomy for stroke. Both symptomatic ICH and asymptomatic ICH have been shown to portend a worse prognosis after thrombectomy in patients with ASP…

O-009 Projected increase in thrombectomy volume based on large core trials Open

Osman Mir, Deep Pujara · 2023

Endovascular thrombectomy was shown to improve clinical outcomes in patients with large ischemic strokes(LIS) due to anterior circulation large vessel occlusions in 3 randomized controlled trials(RESCUE Japan, SELECT2 & ANGEL ASPECT) rece…

Mechanical Thrombectomy for Large Ischemic Stroke Open

Qi Li, Mohamad Abdalkader, James E. Siegler, Shadi Yaghi, Amrou Sarraj , et al. · 2023

This systematic review and meta-analysis indicates that in patients with LVO stroke with a large ischemic core, EVT was associated with improved functional outcomes over MM without increasing sICH risk. The results of ongoing RCTs may prov…

Abstract Number ‐ 22: Hemorrhagic Outcomes in Patients Demonstrating Early Venous Filling After Mechanical Thrombectomy For Acute Ischemic Stroke Open

Faisal Al‐Shaibi, Deep Pujara, Ameer E Hassan, Michael Abraham, Clark Sitton , et al. · 2023

Introduction Endovascular thrombectomy (EVT) for acute ischemic infarcts with large vessel occlusion have been shown to improve functional outcomes. However, there is still the risk of hemorrhagic transformation (HT). Early identification …

Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well Open

Amrou Sarraj, Timothy Kleinig, Ameer E Hassan, Père-Joan Cardona, Santiago Ortega‐Gutiérrez , et al. · 2022

Importance The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours of the time they were last known well. Objective To evaluate functional and safety outcomes for endovascular thrombectomy (EVT) vs medica…

Thrombectomy Outcomes With General vs Nongeneral Anesthesia Open

Amrou Sarraj, Gregory W. Albers, Peter Mitchell, Ameer E Hassan, Michael Abraham , et al. · 2022

EXTEND-IA: ClinicalTrials.gov (NCT01492725); EXTEND-IA TNK: ClinicalTrials.gov (NCT02388061); EXTEND-IA TNK part II: ClinicalTrials.gov (NCT03340493); and SELECT: ClinicalTrials.gov (NCT02446587).

Accuracy of CT Perfusion–Based Core Estimation of Follow-up Infarction Open

Amrou Sarraj, Bruce Campbell, Sören Christensen, Clark Sitton, Shekhar Khanpara , et al. · 2022

ClinicalTrials.gov: NCT03876457.

Impact of Acute Confusional State in Patients With COVID-19 and a Predictive Score Open

Bhanu Gogia, Deep Pujara, Neeharika Thottempudi, Tamer Ghanayem, Yousaf Ajam , et al. · 2021

P-029 Impact of in-hospital delirium on outcomes of acute ischemic stroke Open

Deep Pujara, Haris Kamal, Osman Mir, Singam Sivasankar Reddy, Kaushik Parsha , et al. · 2021

Introduction Delirium is a common complication after acute ischemic stroke(AIS) and is usually associated with worse outcomes. Nationally representative estimates on the prevalence of in-hospital delirium after AIS are not well established…

Direct to Angiography vs Repeated Imaging Approaches in Transferred Patients Undergoing Endovascular Thrombectomy Open

Amrou Sarraj, Nitin Goyal, Michael Chen, James C. Grotta, Spiros Blackburn , et al. · 2021

The DTA approach may be associated with faster treatment and better functional outcomes during all hours and treatment windows, and repeated imaging may be reasonable with prolonged transfer times. Optimal EVT workflow in transfers may be …

Clinical and Neuroimaging Outcomes of Direct Thrombectomy vs Bridging Therapy in Large Vessel Occlusion Open

Amrou Sarraj, James C. Grotta, Gregory W. Albers, Ameer E Hassan, Spiros Blackburn , et al. · 2021

This study provides Class III evidence that for patients with ischemic stroke from anterior circulation LVO within 4.5 hours from last known well, BT compared to dEVT leads to better 90-day functional outcomes.

Clinical Outcomes and Identification of Patients With Persistent Penumbral Profiles Beyond 24 Hours From Last Known Well Open

Amrou Sarraj, Michael Mlynash, Jeremy J. Heit, Deep Pujara, Maarten G. Lansberg , et al. · 2021

Background and Purpose: DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3) infarct volumes at 24 hours did not significantly differ in the endovascular thrombectomy (EVT) versus medical management (MM) only …

Early Infarct Growth Rate Correlation With Endovascular Thrombectomy Clinical Outcomes Open

Amrou Sarraj, Ameer E Hassan, James C. Grotta, Spiros Blackburn, Arthur L. Day , et al. · 2020

Background and Purpose: Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. Methods: In a prospective multicenter cohort study of imaging selection for endovascu…

Left atrial posterior wall isolation in conjunction with pulmonary vein isolation using cryoballoon for treatment of persistent atrial fibrillation (PIVoTAL): study rationale and design Open

Arash Aryana, Deep Pujara, Shelley L. Allen, James H. Baker, Martin A. Espinosa , et al. · 2020

Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules Open

Ruth L. Katz, Tanweer M. Zaidi, Deep Pujara, Namita Shanbhag, Duy Hieu Truong , et al. · 2020

Background Approximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically during lung cancer screening are negative, thus exposing cancer‐free patients to ris…

Endovascular Thrombectomy for Acute Ischemic Strokes Open

Amrou Sarraj, Sean I. Savitz, Deep Pujara, Haris Kamal, Kirsten Carroll , et al. · 2020

Background and Purpose— Timely access to endovascular thrombectomy (EVT) centers is vital for best acute ischemic stroke outcomes. Methods— US stroke-treating centers were mapped utilizing geo-mapping and stratified into non-EVT or EVT if …

Abstract 129: Endovascular Thrombectomy Potential Benefits in Isolated M2 Occlusions Are Related to Stroke Severity and Penumbral Mismatch Deficit: A Secondary Analysis From the SELECT Study Open

Amrou Sarraj, Ameer E Hassan, James C. Grotta, Clark Sitton, Spiros Blackburn , et al. · 2020

Background: The efficacy of endovascular thrombectomy (EVT) in M2 occlusions is uncertain. Methods: In a prospective multicenter cohort study of imaging selection (SELECT), EVT outcomes were compared to medical managment (MM) in M2 occlusi…

Outcomes of Endovascular Thrombectomy vs Medical Management Alone in Patients With Large Ischemic Cores Open

Amrou Sarraj, Ameer E Hassan, Sean I. Savitz, Clark Sitton, James C. Grotta , et al. · 2019

Although the odds of good outcomes for patients with large cores who receive EVT markedly decline with increasing core size and time to treatment, these data suggest potential benefits. Randomized clinical trials are needed.

Complex Left Atrial Appendage Morphology Is an Independent Risk Factor for Cryptogenic Ischemic Stroke Open

Indranill Basu‐Ray, Deepthi Sudhakar, Gregory Schwing, Dominique Monlezun, Lucy Zhang , et al. · 2018

Importance: Ischemic strokes pose a significant health burden. However, the etiology of between 20 and 40% of these events remains unknown. Left atrial appendage morphology may influence the occurrence of thromboembolic events. D…

View article: Investigating a Novel Synergy Applying Remote Ischemic Conditioning to Modulate the Altered Physiology of ContinUous Flow Left Ventricular Assist Devices, to Reduce Stroke and Other Adverse Effects: The IMPULSE Trial Pilot Results

Investigating a Novel Synergy Applying Remote Ischemic Conditioning to Modulate the Altered Physiology of ContinUous Flow Left Ventricular Assist Devices, to Reduce Stroke and Other Adverse Effects: The IMPULSE Trial Pilot Results Open

Deep Pujara, Hari R. Mallidi, William E. Cohn, Jatin Anand, O.H. Frazier , et al. · 2016

View article: Procedural and biophysical indicators of durable pulmonary vein isolation during cryoballoon ablation of atrial fibrillation

Procedural and biophysical indicators of durable pulmonary vein isolation during cryoballoon ablation of atrial fibrillation Open

Arash Aryana, Giacomo Mugnai, Sheldon M. Singh, Deep Pujara, Carlo de Asmundis , et al. · 2015

View article: Comprehensive geriatric assessment in patients with gastric and gastroesophageal adenocarcinoma undergoing gastrectomy

Comprehensive geriatric assessment in patients with gastric and gastroesophageal adenocarcinoma undergoing gastrectomy Open

Deep Pujara, Paul Mansfield, Jaffer A. Ajani, Mariela A. Blum, Elena Elimova , et al. · 2015

Objective The purpose of this study was to identify clinical and geriatric assessment variables associated with outcome in patients with gastric adenocarcinoma who have undergone gastrectomy. Methods We reviewed demographic, clinical, and …