Deepa M. Gopal
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View article: Quantification of Exercised-Induced Myocardial Deformation with Exercise CMR
Quantification of Exercised-Induced Myocardial Deformation with Exercise CMR Open
Ex-CMR-derived MTR enables quantification of exercise-induced rotational deformation and mechanical reserve through single-beat myocardial tagging. In a pilot clinical study, MTR values distinguished patients with exercise-induced or overt…
View article: Multiomics investigation of the female hypertensive human heart
Multiomics investigation of the female hypertensive human heart Open
Hypertension affects 1 in 2 adults in the United States and is the leading risk factor for myocardial infarction and chronic kidney disease. While animal models have advanced our understanding of the effects of hypertension on the heart, m…
View article: Depression, anxiety, stress, and resting blood pressure between cisgender queer and heterosexual emerging adults
Depression, anxiety, stress, and resting blood pressure between cisgender queer and heterosexual emerging adults Open
Our study extends the literature on cardiovascular risk factors in queer populations by identifying a critical time point when queer emerging adults have higher levels of stress and anxiety than their heterosexual peers, but no differences…
View article: Wild-Type Transthyretin Amyloidosis in the Kidneys
Wild-Type Transthyretin Amyloidosis in the Kidneys Open
Wild-type transthyretin (ATTRwt) amyloidosis typically presents with restrictive cardiomyopathy. Kidney involvement is exceedingly rare. We report to our knowledge the first antemortem diagnosis of ATTRwt amyloidosis with kidney vasculatur…
View article: A multi-biomarker approach to risk stratification and detection of early cardiac disease in systemic sclerosis
A multi-biomarker approach to risk stratification and detection of early cardiac disease in systemic sclerosis Open
Objective We sought to investigate the relationship between serum biomarkers of cardiac dysfunction, longitudinal strain on echocardiography, and all-cause mortality in patients with systemic sclerosis. Methods This was an observational st…
View article: Antitrypanosomal therapy for Chagas disease: A single center experience with adverse drug reactions and strategies for enhancing treatment completion
Antitrypanosomal therapy for Chagas disease: A single center experience with adverse drug reactions and strategies for enhancing treatment completion Open
Anti-trypanosomal therapy is generally recommended for individuals under age 50 with the indeterminate form of Chagas disease to prevent disease progression. However, benznidazole and nifurtimox are associated with adverse drug reactions. …
View article: Organ Donation for Research Biobanking Among Historically Marginalized Racial and Ethnic Groups
Organ Donation for Research Biobanking Among Historically Marginalized Racial and Ethnic Groups Open
Importance Research biobanks of human cells and tissues, particularly tissues accessible only after death, are crucial for advancing the understanding of human pathophysiological function. Research biobanks are bereft of tissues from indiv…
View article: Exercise CMR-derived work-volume loop in exercise-induced HFpEF
Exercise CMR-derived work-volume loop in exercise-induced HFpEF Open
View article: Exercise cardiovascular magnetic resonance myocardial dynamic index: A non-invasive imaging marker associated with cardiac dyspnea
Exercise cardiovascular magnetic resonance myocardial dynamic index: A non-invasive imaging marker associated with cardiac dyspnea Open
Ex-CMR MDI is independently associated with cardiac dyspnea and strongly correlates with the VO₂ max index. It aids in differentiating cardiac from non-cardiac dyspnea and provides incremental diagnostic value beyond conventional clinical …
View article: A systematic review on the biochemical threshold of mitochondrial genetic variants
A systematic review on the biochemical threshold of mitochondrial genetic variants Open
Mitochondrial DNA (mtDNA) variants cause a range of diseases from severe pediatric syndromes to aging-related conditions. The percentage of mtDNA copies carrying a pathogenic variant, variant allele frequency (VAF), must reach a threshold …
View article: Chagas cardiomyopathy in Boston, Massachusetts: Identifying disease and improving management after community and hospital-based screening
Chagas cardiomyopathy in Boston, Massachusetts: Identifying disease and improving management after community and hospital-based screening Open
Background Limited data exist regarding cardiac manifestations of Chagas disease in migrants living in non-endemic regions. Methods A retrospective cohort analysis of 109 patients with Chagas disease seen at Boston Medical Center (BMC) bet…
View article: Role of Left Ventricular Dysfunction in Systemic Sclerosis-Related Pulmonary Hypertension
Role of Left Ventricular Dysfunction in Systemic Sclerosis-Related Pulmonary Hypertension Open
View article: Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease
Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease Open
Background and Aims The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood. Methods We included…
View article: Elevated cardiac biomarkers in relatively healthy U.S. adults
Elevated cardiac biomarkers in relatively healthy U.S. adults Open
View article: 1407. Migration Timing and its Association with Disease Features in a Chagas Disease Cohort in New England
1407. Migration Timing and its Association with Disease Features in a Chagas Disease Cohort in New England Open
Background Chagas disease is under-recognized in the United States (US) and little is known about how time spent living in endemic versus non-endemic settings affects features of the disease. Methods We performed a cross-sectional, retrosp…
View article: Elevated Cardiac Biomarkers in Relatively Healthy U.S. Adults
Elevated Cardiac Biomarkers in Relatively Healthy U.S. Adults Open
Background Despite the importance of early cardiovascular disease (CVD) intervention, little data exists for evaluating cardiovascular risk in adults without traditional CVD risk factors (e.g., diabetes, hypertension). Methods We included …
View article: Obesity-Related Differences in Pathomechanism and Outcomes in Patients With HFpEF
Obesity-Related Differences in Pathomechanism and Outcomes in Patients With HFpEF Open
View article: A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension
A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension Open
View article: Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study
Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study Open
Background While exercise impairments are central to symptoms and diagnosis of heart failure with preserved ejection fraction (HFpEF), prior studies of HFpEF biomarkers have mostly focused on resting phenotypes. We combined precise exercis…
View article: Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis
Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis Open
Patients with advanced cardiac immunoglobulin light chain (AL) amyloidosis have a poor prognosis. Early hematologic and cardiac responses can prolong survival, but predictors of these outcomes have yet to be clarified. We report on 142 pat…
View article: Metabolomic Profiles, Ideal Cardiovascular Health, and Risk of Heart Failure and Atrial Fibrillation: Insights From the Framingham Heart Study
Metabolomic Profiles, Ideal Cardiovascular Health, and Risk of Heart Failure and Atrial Fibrillation: Insights From the Framingham Heart Study Open
Background The American Heart Association's framework “ideal cardiovascular health” (CVH) focuses on modifiable risk factors to reduce cardiovascular disease (CVD). Metabolomics provides important pathobiological insights into risk factors…
View article: Importance of survey demographic questions to foster inclusion in medicine and research and reduce health inequities for LGBTQIA2S+ individuals
Importance of survey demographic questions to foster inclusion in medicine and research and reduce health inequities for LGBTQIA2S+ individuals Open
A clear, inclusive, and accurate approach to the collection of demographic information in clinical research and medical practice is critical to understanding the healthcare needs of the specific population. Inclusive demography constitutes…
View article: Correction to: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis‑Related Pulmonary Hypertension
Correction to: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis‑Related Pulmonary Hypertension Open
View article: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension
Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension Open
View article: Systematic dissection, preservation, and multiomics in whole human and bovine hearts
Systematic dissection, preservation, and multiomics in whole human and bovine hearts Open
View article: Light Chain Testing Abnormalities Among Patients With Transthyretin Amyloid Cardiomyopathy Referred for Technetium-99m Pyrophosphate Imaging
Light Chain Testing Abnormalities Among Patients With Transthyretin Amyloid Cardiomyopathy Referred for Technetium-99m Pyrophosphate Imaging Open
View article: Inefficient Batteries in Heart Failure
Inefficient Batteries in Heart Failure Open
Mitochondrial abnormalities have long been described in the setting of cardiomyopathies and heart failure (HF), yet the mechanisms of mitochondrial dysfunction in cardiac pathophysiology remain poorly understood. Many studies have describe…
View article: Heteroplasmic Mitochondrial Genetic Variation in the Human Heart
Heteroplasmic Mitochondrial Genetic Variation in the Human Heart Open
Whether heteroplasmic mitochondrial genetic variants in readily accessible tissues (blood, skeletal muscle) reflect those in the human heart (atrial appendage, left ventricle) is unknown. Using next generation sequencing data from paired t…
View article: A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis
A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis Open
Objective Diagnosis of pulmonary hypertension (PH) in systemic sclerosis (SSc) requires an invasive right heart catheterization (RHC), often based on an elevated estimated pulmonary artery systolic pressure on screening echocardiography. H…
View article: Diflunisal treatment is associated with improved survival for patients with early stage wild-type transthyretin (ATTR) amyloid cardiomyopathy: the Boston University Amyloidosis Center experience
Diflunisal treatment is associated with improved survival for patients with early stage wild-type transthyretin (ATTR) amyloid cardiomyopathy: the Boston University Amyloidosis Center experience Open
Diflunisal is a non-steroidal anti-inflammatory drug that stabilises transthyretin (TTR) and reduces neurologic deterioration in patients with polyneuropathy caused by hereditary transthyretin amyloidosis (ATTRv). We conducted a retrospect…