Deepa Raju
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View article: Bespoke Activity-Based Probes Reveal that the <i>Pseudomonas aeruginosa</i> Endoglycosidase, PslG, Is an Endo-β-glucanase
Bespoke Activity-Based Probes Reveal that the <i>Pseudomonas aeruginosa</i> Endoglycosidase, PslG, Is an Endo-β-glucanase Open
During infection, the human opportunistic pathogen Pseudomonas aeruginosa forms protective biofilms, whose matrix consists of proteins, nucleic acids, and polysaccharides such as alginate, Psl, and Pel. Psl, a polymeric pentasaccharide com…
View article: The role of exopolysaccharides Psl and Pel in resistance of <i>Pseudomonas aeruginosa</i> to the oxidative stressors sodium hypochlorite and hydrogen peroxide
The role of exopolysaccharides Psl and Pel in resistance of <i>Pseudomonas aeruginosa</i> to the oxidative stressors sodium hypochlorite and hydrogen peroxide Open
Pseudomonas aeruginosa is well-known for its antimicrobial resistance and the ability to survive in harsh environmental conditions due to an abundance of resistance mechanisms, including the formation of biofilms and the production of exop…
View article: Autoaggregation in<i>Streptococcus intermedius</i>is driven by the Pel polysaccharide
Autoaggregation in<i>Streptococcus intermedius</i>is driven by the Pel polysaccharide Open
The Streptococcus Milleri Group (SMG) comprising of Streptococcus intermedius, anginosus and constellatus are commensal bacteria commonly found in healthy individuals. These bacteria are increasingly being recognized as opportunistic patho…
View article: Retraction for Harrison et al., “Molecular Characterization of <i>Clostridium perfringens</i> Isolates from Humans with Sporadic Diarrhea: Evidence for Transcriptional Regulation of the Beta2-Toxin-Encoding Gene”
Retraction for Harrison et al., “Molecular Characterization of <i>Clostridium perfringens</i> Isolates from Humans with Sporadic Diarrhea: Evidence for Transcriptional Regulation of the Beta2-Toxin-Encoding Gene” Open
Volume 71, no. 12, p. 8362–8370, 2005, https://doi.org/10.1128/AEM.71.12.8362-8370.2005. The authors hereby retract this article. The authors have been alerted that Fig. 2 and 3 do not accurately reflect the original images. Specifically, …
View article: Retraction for Waters et al., “Regulated Expression of the Beta2-Toxin Gene ( <i>cpb2</i> ) in <i>Clostridium perfringens</i> Type A Isolates from Horses with Gastrointestinal Diseases”
Retraction for Waters et al., “Regulated Expression of the Beta2-Toxin Gene ( <i>cpb2</i> ) in <i>Clostridium perfringens</i> Type A Isolates from Horses with Gastrointestinal Diseases” Open
Volume 43, no. 8, p. 4002–4009, 2005, https://doi.org/10.1128/JCM.43.8.4002-4009.2005. The authors hereby retract this article. The authors have been alerted that Fig. 1B, 2A, 2B, and 4A do not reflect accurate data. Specifically, in Fig. …
View article: PNAG exopolysaccharide eradication gives neutrophils access to<i>Staphylococcus aureus</i>biofilm infections
PNAG exopolysaccharide eradication gives neutrophils access to<i>Staphylococcus aureus</i>biofilm infections Open
Staphylococcus aureus ( S. aureus ) can form biofilms on biotic or abiotic surfaces making biofilm infections a relevant clinical problem. Biofilms can evade immunity and resist antimicrobial treatment, and as such an understanding of biof…
View article: Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen
Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen Open
Infections and disease caused by the obligate human pathogen Bordetella pertussis ( Bp ) are increasing, despite widespread vaccinations. The current acellular pertussis vaccines remain ineffective against nasopharyngeal colonization, carr…
View article: Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection Open
The bacterium Pseudomonas aeruginosa can colonize the airways of patients with chronic lung disease. Within the lung, P. aeruginosa forms biofilms that can enhance resistance to antibiotics and immune defenses. P. aeruginosa biofilm format…
View article: Bps polysaccharide of <i>Bordetella pertussis</i> resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts <i>Escherichia coli</i> into a respiratory pathogen
Bps polysaccharide of <i>Bordetella pertussis</i> resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts <i>Escherichia coli</i> into a respiratory pathogen Open
Infections and disease caused by the obligate human pathogen Bordetella pertussis (Bp) are increasing, despite widespread vaccinations. The current acellular pertussis vaccines remain ineffective against nasopharyngeal colonization, carria…
View article: Preventing <i>Pseudomonas aeruginosa</i> Biofilms on Indwelling Catheters by Surface-Bound Enzymes
Preventing <i>Pseudomonas aeruginosa</i> Biofilms on Indwelling Catheters by Surface-Bound Enzymes Open
Implanted medical devices such as central venous catheters are highly susceptible to microbial colonization and biofilm formation and are a major risk factor for nosocomial infections. The opportunistic pathogen Pseudomonas aeruginosa uses…
View article: Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis Open
The biofilm-forming mold Aspergillus fumigatus is a common causative agent of invasive fungal airway disease in patients with a compromised immune system or chronic airway disease. Treatment of A. fumigatus infection is limited by the few …
View article: Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity
Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity Open
Pseudomonas aeruginosa is an opportunistic, nosocomial bacterial pathogen that forms persistent infections due to the formation of protective communities, known as biofilms. Once the biofilm is formed, the bacteria embedded within it are r…
View article: Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence
Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence Open
Legionellosis is a severe respiratory illness caused by the inhalation of aerosolized water droplets contaminated with the opportunistic pathogen Legionella pneumophila. The ability of L. pneumophila to produce biofilms has been associated…
View article: Small Rho GTPases and the Effector VipA Mediate the Invasion of Epithelial Cells by Filamentous Legionella pneumophila
Small Rho GTPases and the Effector VipA Mediate the Invasion of Epithelial Cells by Filamentous Legionella pneumophila Open
Legionella pneumophila (Lp) exhibits different morphologies with varying degrees of virulence. Despite their detection in environmental sources of outbreaks and in respiratory tract secretions and lung autopsies from patients, the filament…