Deepa Upreti
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View article: Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps
Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps Open
The field of ncRNA research in pathologies associated with alcohol use is still emerging. Given the enormous sizes and species variations of mammalian ncRNA genomes, a significant amount of research is needed to identify relevant ncRNAs in…
View article: Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure
Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure Open
Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alco…
View article: <i>Euglena gracilis</i> Extract Protects From Tobacco Smoke Carcinogen-Induced Lung Cancer by Altering Gut Microbiota Metabolome
<i>Euglena gracilis</i> Extract Protects From Tobacco Smoke Carcinogen-Induced Lung Cancer by Altering Gut Microbiota Metabolome Open
Extracts from Euglena gracilis have been shown to prevent cancer growth in mouse models. However, the molecular mechanism of this anti-cancer activity has not been determined nor has the effect of Euglena extracts on tobacco smoke carcinog…
View article: Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint
Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint Open
A cyclic peptide targeted to the immune checkpoint protein CTLA4 is designed using a hierarchy of computational methods, demonstrated to bind by a physical measurement, and shown to inhibit tumor growth in cell culture and in mice.
View article: A Water Extract from Chlorella sorokiniana Cell Walls Stimulates Growth of Bone Marrow Cells and Splenocytes
A Water Extract from Chlorella sorokiniana Cell Walls Stimulates Growth of Bone Marrow Cells and Splenocytes Open
A water extract derived from the isolated cell walls of Chlorella sorokiniana (C. sorokiniana, Chlorella water extract, CWE) was analyzed for the presence of lipopolysaccharide (LPS)-related material via the Limulus amebocyte lysate (LAL) …
View article: Oral Administration of Water Extract from Euglena gracilis Alters the Intestinal Microbiota and Prevents Lung Carcinoma Growth in Mice
Oral Administration of Water Extract from Euglena gracilis Alters the Intestinal Microbiota and Prevents Lung Carcinoma Growth in Mice Open
The antitumor effects of a partially purified water extract from Euglena gracilis (EWE) and EWE treated by boiling (bEWE) were evaluated using orthotopic lung cancer syngeneic mouse models with Lewis lung carcinoma (LLC) cells. Daily oral …
View article: Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice
Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice Open
View article: Water extract from Euglena gracilis prevents lung carcinoma growth in mice by attenuation of the myeloid-derived cell population
Water extract from Euglena gracilis prevents lung carcinoma growth in mice by attenuation of the myeloid-derived cell population Open
View article: Cell Wall Membrane Fraction of <i>Chlorella sorokiniana</i> Enhances Host Antitumor Immunity and Inhibits Colon Carcinoma Growth in Mice
Cell Wall Membrane Fraction of <i>Chlorella sorokiniana</i> Enhances Host Antitumor Immunity and Inhibits Colon Carcinoma Growth in Mice Open
A colon cancer growth inhibitor partially purified from the isolated cell wall membrane fraction of Chlorella sorokiniana, here referred to as Chlorella membrane factor (CMF), was evaluated for its antitumor and immunomodulatory effects in…
View article: Diagnostics for Rift Valley fever virus
Diagnostics for Rift Valley fever virus Open