Deepak Ailani
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View article: Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma
Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma Open
Immune evasion and suppression lead to unchecked tumor growth in glioblastoma. Cytomegalovirus (CMV) has been implicated in tumor progression and modulation in glioblastoma. To investigate this potential connection, CMV-associated changes …
View article: Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency
Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency Open
Heterozygous variants in GBA1, encoding glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also have a substantial reduction of GCase activity. Genetic variants …
View article: A bidirectional network for appetite control in larval zebrafish
A bidirectional network for appetite control in larval zebrafish Open
Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here we report that, in larval zebrafish, primarily s…
View article: Unexpected opposing biological effect of genetic risk factors for Parkinson’s disease
Unexpected opposing biological effect of genetic risk factors for Parkinson’s disease Open
The additive effect of genetic risk variants on overall disease risk is a plausible but frequently unproven hypothesis. To test this hypothesis, we assessed the biological effect of combined glucocerebrosidase (GCase) and acid sphingomyeli…
View article: Author response: A bidirectional network for appetite control in larval zebrafish
Author response: A bidirectional network for appetite control in larval zebrafish Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Medial and lateral…
View article: Author response: A bidirectional network for appetite control in larval zebrafish
Author response: A bidirectional network for appetite control in larval zebrafish Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Medial and lateral…
View article: Activation of the hypothalamic feeding centre upon visual prey detection
Activation of the hypothalamic feeding centre upon visual prey detection Open
The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic feeding centre is la…