Deepak Bhamidipati
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View article: Long-Term Efficacy of Pembrolizumab and the Clinical Utility of ctDNA in Locally Advanced dMMR/MSI-H Solid Tumors
Long-Term Efficacy of Pembrolizumab and the Clinical Utility of ctDNA in Locally Advanced dMMR/MSI-H Solid Tumors Open
Neoadjuvant immunotherapy can induce pathologic complete response (pCR) in patients with localized deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) tumors. The long-term outcomes of these patients are unknown, as is…
View article: The Clinical Utility of a Next-Generation Sequencing-Based Approach to Detecting Circulating HPV DNA in Patients with Advanced Anal Cancer
The Clinical Utility of a Next-Generation Sequencing-Based Approach to Detecting Circulating HPV DNA in Patients with Advanced Anal Cancer Open
Background: To extend the practicality of liquid biopsy beyond the historical HPV circulating tumor DNA (ctDNA) assays, we evaluated the clinical relevance of a novel next-generation sequencing HPV ctDNA assay in patients with locally adva…
View article: Durable Remission After Targeted Therapy in <i>BRAF V600E–</i>Mutant Metastatic Colorectal Cancer: Case Report
Durable Remission After Targeted Therapy in <i>BRAF V600E–</i>Mutant Metastatic Colorectal Cancer: Case Report Open
BRAF mutation leads to constitutive activation of the MAPK pathway and is associated with the immune-activating molecular subtype of colorectal cancer. Targeted therapy for BRAF V600E–mutant metastatic colorectal cancer (CRC) has significa…
View article: Targeting All <i>BRAF</i> Alterations: The (Re)-Search Continues
Targeting All <i>BRAF</i> Alterations: The (Re)-Search Continues Open
VivekSubbiah & colleagues delve into the @ASCO #TAPURStudy, shedding light on the importance of targeting ALL #BRAFAlterations, beyond V600E. (Re)-search continues, urging us to push the boundaries and unlock new possibilities in #Precisio…
View article: 143P Genomic characterization and outcomes of patients with primary sclerosing cholangitis-related cholangiocarcinoma
143P Genomic characterization and outcomes of patients with primary sclerosing cholangitis-related cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is the leading cause of death in patients (pts) with primary sclerosing cholangitis (PSC). PSC-related CCA is rare, and there has been no clinical analysis of survival outcomes following surgery, radiation therapy …
View article: Exceptional Responses to Selpercatinib in <i>RET</i> Fusion–Driven Metastatic Pancreatic Cancer
Exceptional Responses to Selpercatinib in <i>RET</i> Fusion–Driven Metastatic Pancreatic Cancer Open
Article Tools CASE REPORTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/PO.23.00252 JCO Precision Oncology no. 7 (…
View article: Table of Contents
Table of Contents Open
View article: PARP inhibitors: enhancing efficacy through rational combinations
PARP inhibitors: enhancing efficacy through rational combinations Open
Poly (ADP-ribose) polymerase inhibitors (PARPi) have significantly changed the treatment landscape for tumours harbouring defects in genes involved in homologous repair (HR) such as BRCA1 and BRCA2 . Despite initial responsiveness to PARPi…
View article: Cracking KRASG12C across all solid tumors: the new kid on the block for tissue-agnostic precision medicine
Cracking KRASG12C across all solid tumors: the new kid on the block for tissue-agnostic precision medicine Open
The landscape of oncologic treatments has transformed substantially over the past several decades, with the proliferation of molecularly targeted therapeutic approaches. Some molecular alterations are inextricably tied to the underlying bi…
View article: Lurbinectedin, a DNA minor groove inhibitor for neuroendocrine neoplasms beyond small cell lung cancer
Lurbinectedin, a DNA minor groove inhibitor for neuroendocrine neoplasms beyond small cell lung cancer Open
View article: Impact of tissue-agnostic approvals for patients with gastrointestinal malignancies
Impact of tissue-agnostic approvals for patients with gastrointestinal malignancies Open
View article: An analysis of research biopsy core variability from over 5000 prospectively collected core samples
An analysis of research biopsy core variability from over 5000 prospectively collected core samples Open
View article: Metastatic small bowel adenocarcinoma: role of metastasectomy and systemic chemotherapy
Metastatic small bowel adenocarcinoma: role of metastasectomy and systemic chemotherapy Open
In well-selected patients with SBA, metastasectomy appears to be associated with improved OS. This improvement was seen across metastasectomy sites, including liver, lung and peritoneal. Anti-programmed cell death protein 1 (PD-1) based im…
View article: On the underreporting of health-related quality of life and regulatory approval
On the underreporting of health-related quality of life and regulatory approval Open
Recently, Marandino et al. [1.Marandino L. La Salvia A. Sonetto C. et al.Deficiencies in health-related quality of life assessment and reporting: a systematic review of oncology randomized phase III trials published between 2012 and 2016.A…
View article: Stereotactic radiosurgery practice patterns for brain metastases in the United States: a national survey
Stereotactic radiosurgery practice patterns for brain metastases in the United States: a national survey Open
View article: PO-0728: Pre-Radiation Tumor Progression Improves Prognostic Stratification In Glioblastoma Patients
PO-0728: Pre-Radiation Tumor Progression Improves Prognostic Stratification In Glioblastoma Patients Open
View article: Correction to: Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment
Correction to: Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment Open
View article: Stereotactic Radiosurgery Practice Patterns for Brain Metastases in the United States: A National Survey
Stereotactic Radiosurgery Practice Patterns for Brain Metastases in the United States: A National Survey Open
Background: Stereotactic radiosurgery (SRS) has emerged as an important modality for the treatment of intracranial metastases. There are currently few established guidelines delineating indications for SRS use and fewer still regarding pla…
View article: Full Issue: Volume 13, Issue 1 - Winter 2018
Full Issue: Volume 13, Issue 1 - Winter 2018 Open
Full Issue: Volume 13, Issue 1 - Winter 2018
View article: Re-irradiation for recurrent glioblastoma multiforme
Re-irradiation for recurrent glioblastoma multiforme Open
As our understanding of normal brain tissue tolerance and radiation technology have improved, central nervous system (CNS) re-irradiation has garnered more attention; whereas, in the past there had been hesitancy due to late toxicity conce…
View article: NIMG-67. PRE-RADIATION TUMOR PROGRESSION IMPROVES PROGNOSTIC STRATIFICATION IN GLIOBLASTOMA PATIENTS
NIMG-67. PRE-RADIATION TUMOR PROGRESSION IMPROVES PROGNOSTIC STRATIFICATION IN GLIOBLASTOMA PATIENTS Open
Glioblastoma (GBM) is a common form of primary brain tumor with poor prognosis. There are few markers which direct therapy. We hypothesize that MRI evidence of tumor progression during the interval between surgical resection and initiation…
View article: RTRB-15CONCURRENT TEMOZOLOMIDE AND HYPOFRACTIONATED RADIOTHERAPY FOR RECURRENT HIGH GRADE GLIOMA
RTRB-15CONCURRENT TEMOZOLOMIDE AND HYPOFRACTIONATED RADIOTHERAPY FOR RECURRENT HIGH GRADE GLIOMA Open
BACKGROUND: Recurrent glioma has a poor prognosis and largely recurs within the irradiated volume. Improvements in radiosensitization are needed. The utility of concurrent temozolomide with hypofractionated radiotherapy for recurrent gliom…