Deepak Dinakaran
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View article: Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer
Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer Open
View article: Survival outcomes among patients with breast cancer and leptomeningeal disease
Survival outcomes among patients with breast cancer and leptomeningeal disease Open
Despite advances in metastatic breast cancer (MBC) management, leptomeningeal disease (LMD) prognosis remains poor. This study evaluates clinicopathological and treatment factors influencing outcomes of MBC patients with LMD treated with r…
View article: Photon Absorption Remote Sensing (PARS): Comprehensive Absorption Imaging Enabling Label-Free Biomolecule Characterization and Mapping
Photon Absorption Remote Sensing (PARS): Comprehensive Absorption Imaging Enabling Label-Free Biomolecule Characterization and Mapping Open
Label-free optical absorption microscopy techniques continue to evolve as promising tools for label-free histopathological imaging of cells and tissues. However, critical challenges relating to specificity and contrast, as compared to curr…
View article: Photon Absorption Remote Sensing Virtual Histopathology: Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies
Photon Absorption Remote Sensing Virtual Histopathology: Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies Open
Photon Absorption Remote Sensing (PARS) enables label-free imaging of subcellular morphology by observing biomolecule specific absorption interactions. Coupled with deep-learning, PARS produces label-free virtual Hematoxylin and Eosin (H&E…
View article: Left hippocampus sparing model for glioblastoma radiotherapy by utilizing knowledge‐based planning and multi‐criteria optimization
Left hippocampus sparing model for glioblastoma radiotherapy by utilizing knowledge‐based planning and multi‐criteria optimization Open
Purpose Results of a prospective, randomized controlled trial at our institute demonstrate an association between the dose to the left hippocampus and neurocognitive decline post‐radiotherapy for patients with glioblastoma. To minimize the…
View article: Comparative Evaluation of LLMs in Clinical Oncology
Comparative Evaluation of LLMs in Clinical Oncology Open
Of the models tested on a standardized set of oncology questions, GPT-4 was observed to have the highest performance. Although this performance is impressive, all LLMs continue to have clinically significant error rates, including examples…
View article: Potential of Ruthenium as a photosensitizer in radiation-activated Photodynamic Therapy (radioPDT)
Potential of Ruthenium as a photosensitizer in radiation-activated Photodynamic Therapy (radioPDT) Open
In Photodynamic Therapy (PDT), light is used to activate photosensitizers (PS) to generate reactive oxygen species (ROS) as a cell-killing mechanism. However, PDT's application is limited to the surface and small size tumors because of the…
View article: Automated Whole Slide Imaging for Label-Free Histology Using Photon Absorption Remote Sensing Microscopy
Automated Whole Slide Imaging for Label-Free Histology Using Photon Absorption Remote Sensing Microscopy Open
This work is a critical advance for integrating label-free optical methods into standard histopathology workflows.
View article: Photon Absorption Remote Sensing Imaging of Breast Needle Core Biopsies Is Diagnostically Equivalent to Gold Standard H&E Histologic Assessment
Photon Absorption Remote Sensing Imaging of Breast Needle Core Biopsies Is Diagnostically Equivalent to Gold Standard H&E Histologic Assessment Open
Photon absorption remote sensing (PARS) is a new laser-based microscope technique that permits cellular-level resolution of unstained fresh, frozen, and fixed tissues. Our objective was to determine whether PARS could provide an image qual…
View article: The use of nanomaterials in advancing photodynamic therapy (PDT) for deep-seated tumors and synergy with radiotherapy
The use of nanomaterials in advancing photodynamic therapy (PDT) for deep-seated tumors and synergy with radiotherapy Open
Photodynamic therapy (PDT) has been under development for at least 40 years. Multiple studies have demonstrated significant anti-tumor efficacy with limited toxicity concerns. PDT was expected to become a major new therapeutic option in tr…
View article: High quantum efficiency ruthenium coordination complex photosensitizer for improved radiation-activated Photodynamic Therapy
High quantum efficiency ruthenium coordination complex photosensitizer for improved radiation-activated Photodynamic Therapy Open
Traditional external light-based Photodynamic Therapy (PDT)’s application is limited to the surface and minimal thickness tumors because of the inefficiency of light in penetrating deep-seated tumors. To address this, the emerging field of…
View article: Photon Absorption Remote Sensing Imaging of Breast Needle Core Biopsies is Diagnostically Equivalent to Gold Standard H&E Histologic Assessment
Photon Absorption Remote Sensing Imaging of Breast Needle Core Biopsies is Diagnostically Equivalent to Gold Standard H&E Histologic Assessment Open
STRUCTURED Abstract OBJECTIVE Photon absorption remote sensing (PARS) is a new laser-based microscope technique that permits cellular level resolution of unstained fresh, frozen, and fixed tissues. Our objective was to determine whether PA…
View article: Automated Whole Slide Imaging for Label-Free Histology using Photon Absorption Remote Sensing Microscopy
Automated Whole Slide Imaging for Label-Free Histology using Photon Absorption Remote Sensing Microscopy Open
The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often destruct…
View article: Virtual histological staining of label-free total absorption photoacoustic remote sensing (TA-PARS)
Virtual histological staining of label-free total absorption photoacoustic remote sensing (TA-PARS) Open
View article: Label-free complete absorption microscopy using second generation photoacoustic remote sensing
Label-free complete absorption microscopy using second generation photoacoustic remote sensing Open
View article: Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS)
Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS) Open
Histopathological visualizations are a pillar of modern medicine and biological research. Surgical oncology relies exclusively on post-operative histology to determine definitive surgical success and guide adjuvant treatments. The current …
View article: Time-domain feature extraction for target-specificity in Photoacoustic Remote Sensing Microscopy
Time-domain feature extraction for target-specificity in Photoacoustic Remote Sensing Microscopy Open
Photoacoustic Remote Sensing (PARS) microscopy is an emerging label-free optical absorption imaging modality. PARS operates by capturing nanosecond-scale optical perturbations generated by photoacoustic pressures. These time-domain (TD) mo…
View article: Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS)
Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS) Open
Histopathological visualizations are a pillar of modern medicine and biological research. Surgical oncology relies exclusively on post-operative histology to determine definitive surgical success and guide adjuvant treatments. The current …
View article: Response and Toxicity Patterns Seen in Patients Treated With Combination Immunotherapy and Radiotherapy in the UNSCARRed (UNresectable Squamous Cell Carcinoma treated With Avelumab and Radical Radiotherapy) Study
Response and Toxicity Patterns Seen in Patients Treated With Combination Immunotherapy and Radiotherapy in the UNSCARRed (UNresectable Squamous Cell Carcinoma treated With Avelumab and Radical Radiotherapy) Study Open
View article: Label-Free Complete Absorption Microscopy Using Second Generation Photoacoustic Remote Sensing
Label-Free Complete Absorption Microscopy Using Second Generation Photoacoustic Remote Sensing Open
In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information…
View article: Label-free virtual Hematoxylin and Eosin (H&E) staining using second generation Photoacoustic Remote Sensing (PARS)
Label-free virtual Hematoxylin and Eosin (H&E) staining using second generation Photoacoustic Remote Sensing (PARS) Open
In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information…
View article: Label-free virtual Hematoxylin and Eosin (H&E) staining using second generation Photoacoustic Remote Sensing (PARS)
Label-free virtual Hematoxylin and Eosin (H&E) staining using second generation Photoacoustic Remote Sensing (PARS) Open
In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information…
View article: Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)
Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT) Open
View article: Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy (Errata)
Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy (Errata) Open
The Journal of Biomedical Optics (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
View article: Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy
Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy Open
The presented dual-contrast PARS microscope enables label-free visualization of tissues with contrast and quality comparable to the current gold standard for histopathological analysis. Thus, the proposed system is well positioned to augme…
View article: Three-Dimensional Virtual Histology in Unprocessed Resected Tissues with\n Photoacoustic Remote Sensing (PARS) Microscopy and Optical Coherence\n Tomography
Three-Dimensional Virtual Histology in Unprocessed Resected Tissues with\n Photoacoustic Remote Sensing (PARS) Microscopy and Optical Coherence\n Tomography Open
Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, the current method for capturing these microscopy images require resource intensive tissue preparation that delays diagnosis for many days to a few …
View article: Three-Dimensional Virtual Histology in Unprocessed Resected Tissues with Photoacoustic Remote Sensing (PARS) Microscopy and Optical Coherence Tomography
Three-Dimensional Virtual Histology in Unprocessed Resected Tissues with Photoacoustic Remote Sensing (PARS) Microscopy and Optical Coherence Tomography Open
Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, the current method for capturing these microscopy images require resource intensive tissue preparation that delays diagnosis for many days to a few …
View article: Proposal for ‘segmented peer review’ of multidisciplinary papers
Proposal for ‘segmented peer review’ of multidisciplinary papers Open
View article: Histopathology for Mohs micrographic surgery with photoacoustic remote sensing microscopy
Histopathology for Mohs micrographic surgery with photoacoustic remote sensing microscopy Open
Mohs micrographic surgery (MMS) is a precise oncological technique where layers of tissue are resected and examined with intraoperative histopathology to minimize the removal of normal tissue while completely excising the cancer. To achiev…
View article: Reflection-mode virtual histology using photoacoustic remote sensing microscopy
Reflection-mode virtual histology using photoacoustic remote sensing microscopy Open