Deepak Kaushal
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View article: Author response: Mast cells promote pathology and susceptibility in tuberculosis
Author response: Mast cells promote pathology and susceptibility in tuberculosis Open
View article: Type I interferons in tuberculosis pathogenesis and prevention
Type I interferons in tuberculosis pathogenesis and prevention Open
Mycobacterium tuberculosis (Mtb) remains an epidemiological concern due to heterogeneous outcomes in tuberculosis (TB) pathology and the lack of mechanistic understanding of early immune events. Type I interferons (IFNs) in TB are generall…
View article: Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8<sup>+</sup> T cell-macrophage interactions
Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8<sup>+</sup> T cell-macrophage interactions Open
Granulomas, the hallmark of tuberculosis (TB) disease, can both restrict Mycobacterium tuberculosis (Mtb) dissemination and impede its clearance. Recent studies indicate that indoleamine 2,3-dioxygenase (IDO1), an immunosuppressive metabol…
View article: PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy
PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy Open
Mycobacterium tuberculosis ( Mtb ) infection induces widespread epigenetic changes in monocytes and macrophages. To characterize the critical factor responsible for Mtb -induced epigenetic responses, we performed an integrative analyses of…
View article: Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines
Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines Open
To radically diminish tuberculosis (TB) incidence and mortality by 2035, as set out by the WHO End TB Strategy, there is a desperate need for improved TB therapies and a more effective vaccine against the deadly pathogen Mycobacterium tube…
View article: Single-cell transcriptome analysis of bronchoalveolar lavage during early SARS-CoV-2 infection
Single-cell transcriptome analysis of bronchoalveolar lavage during early SARS-CoV-2 infection Open
The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has led to global consequences since its emergence in late 2019, impacting health, economies, and societies worldwide. Understanding the early responses following infection will pro…
View article: Using Imaris to rigorously track PET-defined sites of lung inflammation in <i>Mycobacterium tuberculosis</i>-exposed non-human primates
Using Imaris to rigorously track PET-defined sites of lung inflammation in <i>Mycobacterium tuberculosis</i>-exposed non-human primates Open
Aerosol exposure of non-human primates ( NHPs ) to Mycobacterium tuberculosis ( Mtb ) typically results in discrete sites of inflammation of the lung that is detectable by 2-deoxy-2-[fluorine-18]fluoro-D-glucose ( 18 F- FDG )-based PET/CT …
View article: Distinct clinical outcomes in pediatric tuberculosis: A study utilizing infant macaques exposed to aerosol Mycobacterium tuberculosis
Distinct clinical outcomes in pediatric tuberculosis: A study utilizing infant macaques exposed to aerosol Mycobacterium tuberculosis Open
View article: The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research
The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research Open
Background Rhesus macaques are the preferred non-human primate model for HIV/AIDS-related research. Specific major histocompatibility complex (MHC) haplotypes and genetic ancestry are linked to slow disease progression of Simian Immunodefi…
View article: Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate
Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate Open
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacille Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (M…
View article: Mast cells promote pathology and susceptibility in tuberculosis
Mast cells promote pathology and susceptibility in tuberculosis Open
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), infects approximately one-fourth of the world’s population. While most infected individuals are asymptomatic, latent TB infection (LTBI) can progress to cause pul…
View article: Mast cells promote pathology and susceptibility in tuberculosis
Mast cells promote pathology and susceptibility in tuberculosis Open
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), infects approximately one-fourth of the world’s population. We reported an increased accumulation of mast cells (MCs) in the lungs of macaques with active pulmona…
View article: Author Response: Mast cells promote pathology and susceptibility in tuberculosis
Author Response: Mast cells promote pathology and susceptibility in tuberculosis Open
View article: Mast cells promote pathology and susceptibility in tuberculosis
Mast cells promote pathology and susceptibility in tuberculosis Open
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb ), infects approximately one-fourth of the world’s population. We reported an increased accumulation of mast cells (MCs) in the lungs of macaques with active pulmon…
View article: Concurrent TB and HIV therapies effectively control clinical reactivation of TB during co-infection but fail to eliminate chronic immune activation
Concurrent TB and HIV therapies effectively control clinical reactivation of TB during co-infection but fail to eliminate chronic immune activation Open
View article: Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance Open
View article: Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection Open
Chronic immune activation promotes tuberculosis (TB) reactivation in the macaque Mycobacterium tuberculosis (M. tuberculosis)/SIV coinfection model. Initiating combinatorial antiretroviral therapy (cART) early lowers the risk of TB reactiv…
View article: Imaging the Architecture of Granulomas Induced by <i>Mycobacterium tuberculosis</i> Infection with Single-molecule Fluorescence In Situ Hybridization
Imaging the Architecture of Granulomas Induced by <i>Mycobacterium tuberculosis</i> Infection with Single-molecule Fluorescence In Situ Hybridization Open
Granulomas are an important hallmark of Mycobacterium tuberculosis infection. They are organized and dynamic structures created when immune cells assemble around the sites of infection in the lungs that locally restrict M. tuberculosis gro…
View article: Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity
Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity Open
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacillar Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (…
View article: Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis
Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis Open
Tuberculosis (TB) caused by Mycobacterium tuberculosis ( Mtb ) infects up to a quarter of the world’s population. Although immune responses can control Mtb infection, 5%–10% of infected individuals can progress to active TB disease (progre…
View article: Lack of Restoration of TH1 Functions and Immune Activation, by ART, in a Model of Mtb/HIV Co-Infection
Lack of Restoration of TH1 Functions and Immune Activation, by ART, in a Model of Mtb/HIV Co-Infection Open
View article: Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy
Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy Open
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in HIV-infected persons, with one in four deaths attributable to TB. While the majority of he…
View article: Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production
Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production Open
The ADP ribosyltransferases (PARPs 1-17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylati…
View article: Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control
Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control Open
View article: Supplementary Figure 1 from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 1 from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Supplementary Figure 1 from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
View article: Data from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Data from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Mesenchymal stem cells (MSC) derived from bone marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of humans and rhesus macaques were evaluated for their cell cycle properties during protracted culture in vitro. Human ASCs …
View article: Supplementary Figure 2A from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 2A from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Supplementary Figure 2A from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
View article: Supplementary Figure 1 Legend from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 1 Legend from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Supplementary Figure 1 Legend from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
View article: Supplementary Figure 2E from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 2E from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Supplementary Figure 2E from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
View article: Supplementary Figure 2B from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 2B from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells Open
Supplementary Figure 2B from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells