Deepak Kumar Saini
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View article: Multiple Input – Multiple Output (MIMO) Designs in Two-Component Signalling Systems of <i>Mycobacterium tuberculosis</i>
Multiple Input – Multiple Output (MIMO) Designs in Two-Component Signalling Systems of <i>Mycobacterium tuberculosis</i> Open
Two-component systems (TCSs), the primary communication pathways in bacteria, are comprised of two proteins: a signal-sensing histidine kinase (HK) and an output-generating response regulator (RR). Classically, individual TCSs have been vi…
View article: Relating corynebacterial cell envelope layers to its biochemical and physical properties
Relating corynebacterial cell envelope layers to its biochemical and physical properties Open
The cell wall plays a central role in maintaining bacterial shape and structural stability. In the Corynebacteriaceae family, which includes Corynebacterium, Mycobacterium, Nocardia, and Rhodococcus, the …
View article: Mycobacterial MutT1-mediated dephosphorylation of the sensor histidine kinases reveals a new link in the regulation of the two-component signaling
Mycobacterial MutT1-mediated dephosphorylation of the sensor histidine kinases reveals a new link in the regulation of the two-component signaling Open
Bacterial pathogens such as Mycobacterium tuberculosis majorly rely on two-component signaling (TCS) systems to sense and generate adaptive responses to the dynamic and stressful host environment. TCS comprises a sensor histidine kinase (S…
View article: Expanding behavioral interventions through cancer warning labels in India: from cigarette packs to alcohol bottles
Expanding behavioral interventions through cancer warning labels in India: from cigarette packs to alcohol bottles Open
View article: A comprehensive review on nutraceuticals: Therapy support and formulation challenges
A comprehensive review on nutraceuticals: Therapy support and formulation challenges Open
View article: Digitalization in retail pharmacy: Transforming patient care and pharmaceutical services
Digitalization in retail pharmacy: Transforming patient care and pharmaceutical services Open
View article: Unraveling Direct Correlations between Membrane Nanodomain Reorganization and Antimicrobial Resistance Evolution in Bacterial Cells
Unraveling Direct Correlations between Membrane Nanodomain Reorganization and Antimicrobial Resistance Evolution in Bacterial Cells Open
Bacterial drug resistance is a major global health emergency that requires newer approaches for its detection, especially those that are rapid and sensitive at the single cell level. One of the major limitations of existing antimicrobial r…
View article: Stable and Highly Steerable Magnetic Nanorobots Demonstrate Therapeutical Functionality in Crowded Biological Media
Stable and Highly Steerable Magnetic Nanorobots Demonstrate Therapeutical Functionality in Crowded Biological Media Open
Magnetic nanorobots primarily composed of ferromagnetic materials have been extensively investigated for their potential medical applications. Here, we have designed and developed superparamagnetic iron oxide nanoparticles (SPIONs)-functio…
View article: Ameliorating TIMM50 Loss Slows Senescence by Improving Mitochondrial Structure and Function
Ameliorating TIMM50 Loss Slows Senescence by Improving Mitochondrial Structure and Function Open
Mitochondrial dysfunction is an irrefutable hallmark of cellular senescence and aging. The dysfunction is marked by increased mitochondrial volume and reduced function, typified by low Adenosine Triphosphate (ATP) production and higher Rea…
View article: Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots
Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots Open
View article: Mycobacterial MutT1 mediated dephosphorylation of the sensor kinases reveals a new link in the regulation of the two-component signaling in bacteria
Mycobacterial MutT1 mediated dephosphorylation of the sensor kinases reveals a new link in the regulation of the two-component signaling in bacteria Open
Bacterial pathogens such as Mycobacterium tuberculosis majorly rely on two-component signaling (TCS) systems to sense and generate adaptive responses to the dynamic and stressful host environment. TCS comprises a sensor histidine kinase (S…
View article: Non-professional phagocytosis of senescent cancer cells revealed in a 3D-bioprinted model of an irradiated lung tumour
Non-professional phagocytosis of senescent cancer cells revealed in a 3D-bioprinted model of an irradiated lung tumour Open
Three-dimensional (3D) scaffolds represent a transformative tool for studying physiological processes in health and disease contexts by mimicking in vivo conditions that two-dimensional (2D) culture systems cannot capture. This study explo…
View article: Relating corynebacterial cell envelope layers to its biochemical and physical properties
Relating corynebacterial cell envelope layers to its biochemical and physical properties Open
View article: An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase function
An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase function Open
MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any residue. Major MutT proteins hydrolyze 8-oxo-(d)GTP (8-oxo-GTP or 8-oxo-dGTP) to the corr…
View article: Multistep Array-Based Sensing of Bioanalytes Using Modified MoS<sub>2</sub>, Fluorescence Proteins, and Cucurbituril
Multistep Array-Based Sensing of Bioanalytes Using Modified MoS<sub>2</sub>, Fluorescence Proteins, and Cucurbituril Open
One pot sensor by multiplexing in the array is an attractive system for rapid discrimination of multiple analytes. Multiplexing can be achieved in two ways, i.e., using multiple signal transducers or adding sequential agents to the sensor …
View article: A conserved two-component system senses intracellular iron levels and regulates redox balance in <i>Mycobacterium</i> spp.
A conserved two-component system senses intracellular iron levels and regulates redox balance in <i>Mycobacterium</i> spp. Open
For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked. While various oxidative stress and heme-based redox sensors have been rep…
View article: CROSS-JEM: Accurate and Efficient Cross-encoders for Short-text Ranking Tasks
CROSS-JEM: Accurate and Efficient Cross-encoders for Short-text Ranking Tasks Open
Ranking a set of items based on their relevance to a given query is a core problem in search and recommendation. Transformer-based ranking models are the state-of-the-art approaches for such tasks, but they score each query-item independen…
View article: Understanding the Endocrine and Molecular Signaling Cascade Regulation Pathways in Children with Hypospadias
Understanding the Endocrine and Molecular Signaling Cascade Regulation Pathways in Children with Hypospadias Open
Hypospadias (HS) is a congenital defect that occurs due to defective androgenization. It is characterized by the aberrant location of the urinary meatus on the ventral aspect of the penis with various degrees of severity. The molecular mec…
View article: Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages
Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages Open
View article: Advanced 3D <i>In Vitro</i> Lung Fibrosis Models: Contemporary Status, Clinical Uptake, and Prospective Outlooks
Advanced 3D <i>In Vitro</i> Lung Fibrosis Models: Contemporary Status, Clinical Uptake, and Prospective Outlooks Open
Fibrosis has been characterized as a global health problem and ranks as one of the primary causes of organ dysfunction. Currently, there is no cure for pulmonary fibrosis, and limited therapeutic options are available due to an inadequate …
View article: Individualized homoeopathic treatment for benign prostatic hyperplasia: A holistic approach to prostate health: A case report
Individualized homoeopathic treatment for benign prostatic hyperplasia: A holistic approach to prostate health: A case report Open
View article: Anti-cancer drug Tamoxifen interferes with<i>Mycobacterium tuberculosis</i>PhoPR mediated signaling and inhibits mycobacterial growth
Anti-cancer drug Tamoxifen interferes with<i>Mycobacterium tuberculosis</i>PhoPR mediated signaling and inhibits mycobacterial growth Open
Two-component signaling (TCS) systems empower all bacteria, including intracellular pathogens like Mycobacterium tuberculosis (M. tb) to regulate key pathways governing growth, physiology and virulence. Amongst all M. tb TCS systems, PhoPR…
View article: High throughput screening identifies novel pharmacological inhibitors of interferon-gamma-induced nitric oxide production, alleviating ulcerative colitis and bacterial sepsis in mice
High throughput screening identifies novel pharmacological inhibitors of interferon-gamma-induced nitric oxide production, alleviating ulcerative colitis and bacterial sepsis in mice Open
View article: The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells Open
Ovarian cancer is amongst the most morbid of gynecological malignancies due to its diagnosis at an advanced stage, a transcoelomic mode of metastasis, and rapid transition to chemotherapeutic resistance. Like all other malignancies, the pr…
View article: Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds
Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds Open
A typical cellular senescence program involves exposing cells to DNA-damaging agents such as ionization radiation or chemotherapeutic drugs, which cause multipronged changes, including increased cell size and volume, the onset of enhanced …
View article: A Platinum(II) Boron‐dipyrromethene Complex for Cellular Imaging and Mitochondria‐targeted Photodynamic Therapy in Red Light
A Platinum(II) Boron‐dipyrromethene Complex for Cellular Imaging and Mitochondria‐targeted Photodynamic Therapy in Red Light Open
Cisplatin‐derived platinum(II) complexes [Pt(NH 3 ) 2 (pacac)](NO 3 ) ( 1 , DPP‐Pt ) and [Pt(NH 3 ) 2 ( Acac‐RB )](NO 3 ) ( 2 , Acacplatin‐RB ), where Hpacac is 1,3‐diphenyl‐1,3‐propanedione and HAcac‐RB is a red‐light active distyryl‐BODI…
View article: Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling
Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling Open
Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) that perceives a specific signal, and a cognate response regulator (RR) that modulates the expression of target genes. Positive autoregulation improves TCS se…
View article: High throughput screening identifies auranofin and pentamidine as potent compounds that lower IFN-γ-induced Nitric Oxide and inflammatory responses in mice: DSS-induced colitis and Salmonella Typhimurium-induced sepsis
High throughput screening identifies auranofin and pentamidine as potent compounds that lower IFN-γ-induced Nitric Oxide and inflammatory responses in mice: DSS-induced colitis and Salmonella Typhimurium-induced sepsis Open
View article: The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells Open
Ovarian cancer is amongst the most morbid of gynecological malignancies due to its diagnosis at an advanced stage, a transcoelomic mode of metastasis, and rapid transition to chemotherapeutic resistance. Like all other malignancies, the pr…
View article: BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice
BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice Open