Deepak Kumbhare
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View article: Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems
Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems Open
Substance use disorders (SUDs) are chronic disorders marked by intense and compulsive drug-seeking behavior, coupled with a high risk of relapse. Different theories have emerged over time regarding mechanisms that induce and exacerbate SUD…
View article: Identification of predictive factors and development of a prediction model for rehabilitation facility discharge in patients with traumatic spinal cord injury: a retrospective analysis of the National Trauma Data Bank
Identification of predictive factors and development of a prediction model for rehabilitation facility discharge in patients with traumatic spinal cord injury: a retrospective analysis of the National Trauma Data Bank Open
Purpose: Previous studies have shown that early rehabilitation is associated with better long-term outcomes in patients with traumatic spinal cord injury. However, data are still limited regarding which factors are associated with discharg…
View article: Awake prone lateral transpsoas lumbar interbody fusion with simultaneous posterior decompression and fusion: illustrative case
Awake prone lateral transpsoas lumbar interbody fusion with simultaneous posterior decompression and fusion: illustrative case Open
BACKGROUND Awake spine surgery under spinal anesthesia may reduce perioperative risk in older or medically complex patients. This report presents the first documented case of an awake, single-position prone lateral transpsoas interbody fus…
View article: Kinematic analysis of lumbar pedicle screw placement using an artificial intelligence framework
Kinematic analysis of lumbar pedicle screw placement using an artificial intelligence framework Open
OBJECTIVE Robotics and artificial intelligence (AI) are being increasingly integrated in spine surgery. One emerging application of AI is in hand motion detection to assess surgical skill. However, no standardized framework currently exist…
View article: Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.
Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia. Open
Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been preliminarily investigated as a potential treatment for dementia. The degeneration of NBM cholinergic neurons is a pathological feature of many forms of dementia…
View article: Risk Factors and Outcomes of Surgical Site Infections of the Spine: A Retrospective Multi-Center Analysis
Risk Factors and Outcomes of Surgical Site Infections of the Spine: A Retrospective Multi-Center Analysis Open
Background/Objectives: Surgical site infections (SSIs) in spine surgery pose significant risks, including neurological deficits, prolonged hospital stays, and increased healthcare costs. SSIs are classified by their location and include su…
View article: Outcomes of arteriovenous malformation patients with multiple versus single feeders: A multicenter retrospective study with propensity-score matching
Outcomes of arteriovenous malformation patients with multiple versus single feeders: A multicenter retrospective study with propensity-score matching Open
Introduction: The impact of multiple feeding arteries on clinical outcomes of cerebral arteriovenous malformations (AVMs) is not well understood. This study aims to compare outcomes between AVMs with multiple versus single feeding arteries…
View article: Optimizing Single-Position Prone Lateral Lumbar Interbody Fusion with Exoscopic Technology: A Review of Key Innovations
Optimizing Single-Position Prone Lateral Lumbar Interbody Fusion with Exoscopic Technology: A Review of Key Innovations Open
Minimally invasive spine surgery has advanced significantly over the past decade, integrating technologies such as intraoperative navigation, robotics, and artificial intelligence with innovative techniques such as single-position prone la…
View article: Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing
Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing Open
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales and brain regions. Microelectrode arrays (MEAs) are widely used to record neurophysiological activity acro…
View article: Scoping Review of Machine Learning and Patient-Reported Outcomes in Spine Surgery
Scoping Review of Machine Learning and Patient-Reported Outcomes in Spine Surgery Open
Machine learning is an evolving branch of artificial intelligence that is being applied in neurosurgical research. In spine surgery, machine learning has been used for radiographic characterization of cranial and spinal pathology and in pr…
View article: Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing
Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing Open
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales and brain regions. Microelectrode arrays (MEAs) are widely used to record neurophysiological activity acro…
View article: Stereotactic navigation for traumatic parafalcine subdural hematoma evacuation: illustrative cases
Stereotactic navigation for traumatic parafalcine subdural hematoma evacuation: illustrative cases Open
BACKGROUND Parafalcine subdural hematomas (pSDHs) are a subtype of subdural hematoma (SDH) that occur most frequently in older patients after blunt trauma. The literature primarily describes two clinical courses for patients with pSDH: tho…
View article: Stereotactic Radiosurgery in Primary Treatment of Sporadic Small to Medium (<3 cm) Vestibular Schwannomas: A Systematic Review and Meta-Analysis
Stereotactic Radiosurgery in Primary Treatment of Sporadic Small to Medium (<3 cm) Vestibular Schwannomas: A Systematic Review and Meta-Analysis Open
Stereotactic radiosurgery is a safe and effective primary treatment modality for sporadic vestibular schwannoma as shown by the present analysis. Radiosurgery is effective regarding tumor control and hearing preservation and offers a low r…
View article: Clinical Assessment and Management of Acute Spinal Cord Injury
Clinical Assessment and Management of Acute Spinal Cord Injury Open
The information contained in this article is suitable for clinicians practicing in the United States desiring a general overview of the assessment and management of spinal cord injury (SCI), focusing on initial care, assessment, acute mana…
View article: Spinal Anesthesia for Awake Spine Surgery: A Paradigm Shift for Enhanced Recovery after Surgery
Spinal Anesthesia for Awake Spine Surgery: A Paradigm Shift for Enhanced Recovery after Surgery Open
Awake surgery has been applied for various surgical procedures with positive outcomes; however, in neurosurgery, the technique has traditionally been reserved for cranial surgery. Awake surgery for the spine (ASFS) is an alternative to gen…
View article: Deep Brain Stimulation of Nucleus Basalis of Meynert improves learning in rat model of dementia
Deep Brain Stimulation of Nucleus Basalis of Meynert improves learning in rat model of dementia Open
Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been preliminarily investigated as a potential treatment for dementia. The degeneration of NBM cholinergic neurons is a pathological feature of many forms …
View article: Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical‐basal ganglia subcircuit
Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical‐basal ganglia subcircuit Open
Although manifesting contrasting phenotypes, Parkinson's disease and dystonia, the two most common movement disorders, can originate from similar pathophysiology. Previously, we demonstrated that lesioning (silencing) of a discrete dorsal …
View article: Image-Guided Navigation in Spine Surgery: From Historical Developments to Future Perspectives
Image-Guided Navigation in Spine Surgery: From Historical Developments to Future Perspectives Open
Intraoperative navigation is critical during spine surgery to ensure accurate instrumentation placement. From the early era of fluoroscopy to the current advancement in robotics, spinal navigation has continued to evolve. By understanding …
View article: Application of Machine Learning Strategies to Model the Effects of Sevoflurane on Somatosensory-Evoked Potentials during Spine Surgery
Application of Machine Learning Strategies to Model the Effects of Sevoflurane on Somatosensory-Evoked Potentials during Spine Surgery Open
In this study, a small sample of patients’ neuromonitoring data was analyzed using machine learning (ML) tools to provide proof of concept for quantifying complex signals. Intraoperative neurophysiological monitoring (IONM) is a valuable a…
View article: Proposed applications of machine learning to intraoperative neuromonitoring during spine surgeries
Proposed applications of machine learning to intraoperative neuromonitoring during spine surgeries Open
Intraoperative neurophysiological monitoring (IONM) provides data on the state of neurological functionality. However, the current state of technology impedes the reliable and timely extraction and communication of relevant information. Ad…
View article: The Use of Intraoperative Neuromonitoring for Cervical Spine Surgery: Indications, Challenges, and Advances
The Use of Intraoperative Neuromonitoring for Cervical Spine Surgery: Indications, Challenges, and Advances Open
Intraoperative neuromonitoring (IONM) has become an indispensable surgical adjunct in cervical spine procedures to minimize surgical complications. Understanding the historical development of IONM, indications for use, associated pitfalls,…
View article: Transcranial Stimulation for the Treatment of Stimulant Use Disorder
Transcranial Stimulation for the Treatment of Stimulant Use Disorder Open
The increasing prevalence of stimulant use disorder (StUD) involving methamphetamine and cocaine has been a growing healthcare concern in the United States. Cocaine usage is associated with atherosclerosis, systolic and diastolic dysfuncti…
View article: Investigation of soft magnetic material cores in transcranial magnetic stimulation coils and the effect of changing core shapes on the induced electric field in small animals
Investigation of soft magnetic material cores in transcranial magnetic stimulation coils and the effect of changing core shapes on the induced electric field in small animals Open
Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several psychiatric and neurological disorders. Lately, there has been a surge in research utilizing this novel technology in treating other neurol…
View article: Investigation of Soft Magnetic Material Cores in Transcranial Magnetic Stimulation Coils and the Effect of Changing Core Shapes on the Induced Electric Field in Small Animals
Investigation of Soft Magnetic Material Cores in Transcranial Magnetic Stimulation Coils and the Effect of Changing Core Shapes on the Induced Electric Field in Small Animals Open
Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several psychiatric and neurological disorders. Lately, there has been a surge in research utilizing this novel technology in treating other neurol…
View article: Parkinsonism originates in a discrete secondary anddystonia in a primary motor cortical-basal ganglia subcircuit
Parkinsonism originates in a discrete secondary anddystonia in a primary motor cortical-basal ganglia subcircuit Open
Although manifesting contrasting phenotypes, Parkinson’s disease and dystonia originate from similar pathophysiology. Previously, we lesioned a discrete dorsal region in the globus pallidus (rodent equivalent to globus pallidus externa) in…
View article: Quintuple AISI 1010 carbon steel core coil for highly focused transcranial magnetic stimulation in small animals
Quintuple AISI 1010 carbon steel core coil for highly focused transcranial magnetic stimulation in small animals Open
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique used to regulate the synaptic activity of neurons in the brain, improving the functionality of connecting regions and bringing effective treatment to diffe…