Deepak S. Ipe
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View article: Group B Streptococcus growth in human urine is associated with asymptomatic bacteriuria rather than urinary tract infection and is unaffected by iron sequestration
Group B Streptococcus growth in human urine is associated with asymptomatic bacteriuria rather than urinary tract infection and is unaffected by iron sequestration Open
Group B Streptococcus (GBS) causes various infections in adults, including urinary tract infection (UTI) and asymptomatic bacteriuria (ABU). Some bacteria that cause ABU can utilize urine as a substrate for growth, which can promote asympt…
View article: A Novel Apparatus to Standardize the Polishing Protocol to Achieve Different Roughness of Titanium and Zirconia Disc Surfaces
A Novel Apparatus to Standardize the Polishing Protocol to Achieve Different Roughness of Titanium and Zirconia Disc Surfaces Open
The specimens polished under control force produced significantly more uniform surface roughness than those polished without controlled force and were produced with a higher degree of consistency.
View article: Medication‐related osteonecrosis of the jaw: A disease of significant importance for older patients
Medication‐related osteonecrosis of the jaw: A disease of significant importance for older patients Open
Background Medication‐related osteonecrosis of the jaw (MRONJ) is clinically defined as a non‐healing jawbone ulcerative‐necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with anti‐resorptive, an…
View article: The Effect of Titanium Surface Topography on Adherent Macrophage Integrin and Cytokine Expression
The Effect of Titanium Surface Topography on Adherent Macrophage Integrin and Cytokine Expression Open
Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling, as opposed to persistent inflammation and scar tissue formation. This study examined the effect…
View article: Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review
Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review Open
Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. As such, the controll…
View article: Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration
Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration Open
Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts and osteocytes which have a precise role in the context of endochondral and intramembranous ossification. W…
View article: Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract
Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract Open
Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by gapC, is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses …
View article: The Antibacterial and Remineralizing Effects of Biomaterials Combined with DMAHDM Nanocomposite: A Systematic Review
The Antibacterial and Remineralizing Effects of Biomaterials Combined with DMAHDM Nanocomposite: A Systematic Review Open
Researchers have developed novel nanocomposites that incorporate additional biomaterials with dimethylaminohexadecyl methacrylate (DMAHDM) in order to reduce secondary caries. The aim of this review was to summarize the current literature …
View article: Conserved bacterial de novo guanine biosynthesis pathway enables microbial survival and colonization in the environmental niche of the urinary tract
Conserved bacterial de novo guanine biosynthesis pathway enables microbial survival and colonization in the environmental niche of the urinary tract Open
In bacteria, guaA encodes guanosine monophosphate synthetase that confers an ability to biosynthesize guanine nucleotides de novo. This enables bacterial colonization in different environments and, while guaA is widely distributed among Ba…
View article: Higher salivary expression of S100A12 in patients with ulcerative colitis and chronic periodontitis
Higher salivary expression of S100A12 in patients with ulcerative colitis and chronic periodontitis Open
Our research group has a special interest in the association of inflammatory bowel disease (IBD) and chronic periodontitis, an inflammation that affects the alveolar bone and can lead to tooth loss [1]. Both diseases are related to an imba…
View article: Restriction of chronic <i>Escherichia coli</i> urinary tract infection depends upon T cell‐derived interleukin‐17, a deficiency of which predisposes to flagella‐driven bacterial persistence
Restriction of chronic <i>Escherichia coli</i> urinary tract infection depends upon T cell‐derived interleukin‐17, a deficiency of which predisposes to flagella‐driven bacterial persistence Open
Urinary tract infections (UTI) frequently progress to chronicity in infected individuals but the mechanisms of pathogenesis underlying chronic UTI are not well understood. We examined the role of interleukin (IL)‐17A in UTI because this cy…
View article: Evaluation of bacterial kill in human roots infected with <scp><i>Enterococcus faecalis</i></scp> biofilm following 980 nm laser activation of chlorhexidine
Evaluation of bacterial kill in human roots infected with <span><i>Enterococcus faecalis</i></span> biofilm following 980 nm laser activation of chlorhexidine Open
Effectiveness of root canal disinfection greatly determines the success of endodontic treatment. The purpose of this study was to evaluate the bacterial killing efficacy of chlorhexidine (CHX) activated with a Gemni 980 nm diode laser. Bac…
View article: Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics
Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics Open
Antibiotics used to treat bacterial infections can become ineffective over time or result in the emergence of antibiotic resistant pathogens. With the advent of nanotechnology, silver nanoparticles (AgNPs) have gained significant attention…
View article: Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target
Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target Open
The opportunistic pathogen Streptococcus agalactiae is the major cause of meningitis and sepsis in a newborn’s first week, as well as a considerable cause of pneumonia, urinary tract infections, and sepsis in immunocompromised adults. This…
View article: Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391
Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391 Open
Here we report the complete genome sequence of Streptococcus agalactiae strain 874391. This serotype III isolate is a member of the hypervirulent sequence type 17 (ST-17) lineage that causes a disproportionate number of cases of invasive d…
View article: Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391.
Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391. Open
Here we report the complete genome sequence of Streptococcus agalactiae strain 874391. This serotype III isolate is a member of the hypervirulent sequence type 17 (ST-17) lineage that causes a disproportionate number of cases of invasive d…
View article: The bacteriome and mycobiome associated with oral squamous cell carcinoma: metagenomic analysis of samples from Yemeni and Sri Lankan cohorts
The bacteriome and mycobiome associated with oral squamous cell carcinoma: metagenomic analysis of samples from Yemeni and Sri Lankan cohorts Open
There is increasing interest in the possible role of the oral microbiome in oral squamous cell carcinoma (OSSC). However, studies on the possible association between the oral bacteriome and OSCC remain inconclusive, while the potential rol…
View article: A Dysbiotic Mycobiome Dominated by <em>Candida albicans</em> is Identified within Oral Squamous Cell Carcinomas
A Dysbiotic Mycobiome Dominated by <em>Candida albicans</em> is Identified within Oral Squamous Cell Carcinomas Open
Background: Studies employing next-generation sequencing (NGS) show that the oral fungal community (mycobiome) is far more complex than hitherto thought. However, the role of the oral mycobiome in health and disease, including oral c…
View article: A dysbiotic mycobiome dominated by <i>Candida albicans</i> is identified within oral squamous-cell carcinomas
A dysbiotic mycobiome dominated by <i>Candida albicans</i> is identified within oral squamous-cell carcinomas Open
The aim of this study was to characterize the mycobiome associated with oral squamous-cell carcinoma (OSCC). DNA was extracted from 52 tissue biopsies (cases: 25 OSCC; controls: 27 intra-oral fibro-epithelial polyps [FEP]) and sequenced fo…
View article: The <i>Streptococcus agalactiae</i> virulence regulator CovR affects the pathogenesis of urinary tract infection
The <i>Streptococcus agalactiae</i> virulence regulator CovR affects the pathogenesis of urinary tract infection Open
S. agalactiae CovR promotes bladder infection and inflammation, as well as adhesion to and viability of uroepithelial cells. The pathogenesis of S. agalactiae UTI is complex, multifactorial, and influenced by virulence effects of CovR, Hvg…
View article: A Novel Protective Vaccine Antigen from the Core Escherichia coli Genome
A Novel Protective Vaccine Antigen from the Core Escherichia coli Genome Open
E. coli is a multifaceted pathogen of major significance to global human health and an important contributor to increasing antibiotic resistance. Given the paucity of therapies still effective against multidrug-resistant pathogenic E. coli…
View article: Pathogenesis of Streptococcus urinary tract infection depends on bacterial strain and β-hemolysin/cytolysin that mediates cytotoxicity, cytokine synthesis, inflammation and virulence
Pathogenesis of Streptococcus urinary tract infection depends on bacterial strain and β-hemolysin/cytolysin that mediates cytotoxicity, cytokine synthesis, inflammation and virulence Open
Streptococcus agalactiae can cause urinary tract infection (UTI) including cystitis and asymptomatic bacteriuria (ABU). The early host-pathogen interactions that occur during S. agalactiae UTI and subsequent mechanisms of disease pathogene…
View article: Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells
Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells Open
Melioidosis, caused by the bacterium Burkholderia pseudomallei , is an often severe infection that regularly involves respiratory disease following inhalation exposure. Intranasal (i.n.) inoculation of mice represents an experimental appro…
View article: The Basics of Bacteriuria: Strategies of Microbes for Persistence in Urine
The Basics of Bacteriuria: Strategies of Microbes for Persistence in Urine Open
Bacteriuria, the presence of bacteria in urine, is associated with asymptomatic, as well as symptomatic, urinary tract infection (UTI). Bacteriuria underpins some of the dynamics of microbial colonization of the urinary tract, and probably…
View article: Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae
Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae Open
Streptococcus agalactiae causes both symptomatic cystitis and asymptomatic bacteriuria (ABU); however, growth characteristics of S. agalactiae in human urine have not previously been reported. Here, we describe a phenotype of robust growth…
View article: Molecular Mechanisms of Group B Streptococcus Urinary Tract Infection and Adaptability to Growth in Human Urine
Molecular Mechanisms of Group B Streptococcus Urinary Tract Infection and Adaptability to Growth in Human Urine Open
Bacteriuria, or the presence of bacteria in urine, is associated with both asymptomatic, as well as symptomatic urinary tract infection (UTI) and underpins much of the dynamic of microbial colonization of the urinary tract. The prevalence …