Explanipedia

Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC Open

Vikas Kumar, Leena Chauhan, Deepa Singh, Akash Kumar, Rajkumar Kulandaisamy , et al. · 2025

Lung cancer, the second leading cause of cancer mortality, requires the development of novel therapeutic strategies due to emerging drug resistance and toxicity. With this objective, the present work explored the therapeutic potential of R…

Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 Open

Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal , et al. · 2025

Capturing Cross-Section of Return on Nifty 100 Companies: CAPM vs Fama-French Three-Factor Model Open

Khushboo Sagar, Deepak Sehgal · 2025

AGC family kinase of Entamoeba histolytica: Decoding the members biochemically Open

Azhar Ahmad, Vikas Kumar, Tushar Kushwaha, Akash Kumar, Deepak Sehgal , et al. · 2024

Entamoeba histolytica , a protozoan parasite, is the causative agent of amoebiasis, which is a significant global health concern. The virulence mechanisms underlying its pathogenicity are multifaceted and complex. However, endocytic proces…

Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication Open

Akash Kumar, Preeti Hooda, Anindita Puri, Radhika Khatter, Mohammed S. Al‐Dosari , et al. · 2023

Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA…

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors Open

Preeti Hooda, Mohammed S. Al‐Dosari, Neha Sinha, Mohammad Khalid Parvez, Deepak Sehgal · 2023

Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegy…

Interaction of SCoV-2NSP7orNSP8alone withNSP12causes constriction of the RNA entry channel: Implications for novel RdRp inhibitor drug discovery Open

Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal , et al. · 2023

RNA-dependent RNA polymerase (RdRP) is a critical component of the RNA virus life cycle, including SCoV-2. Among the Coronavirus-encoded proteins, non-structural protein 12 ( NSP12 ) exhibits polymerase activity in collaboration with one u…

Inhibition of Hepatitis E Virus Replication by Novel Inhibitor Targeting Methyltransferase Open

Preeti Hooda, Meenakshi Chaudhary, Mohammad Khalid Parvez, Neha Sinha, Deepak Sehgal · 2022

Hepatitis E Virus (HEV) is a quasi-enveloped virus having a single-stranded, positive-sense RNA genome (~7.2 kb), flanked with a 5′ methylated cap and a 3′ polyadenylated tail. The HEV open reading frame 1 (ORF1) encodes a 186-kDa polyprot…

Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in vitro Studies Open

Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh , et al. · 2022

The pandemic caused by SARS-CoV-2 (SCoV-2) has impacted the world in many ways and the virus continues to evolve and produce novel variants with the ability to cause frequent global outbreaks. Although the advent of the vaccines abated the…

Capturing Cross-Section of Return on Nifty 100 Companies: CAPM vs Fama-French Three-Factor Model Open

Deepak Sehgal, Khushboo Sagar · 2022

In order to explain the relationship between risk and expected return, different researchers use different asset pricing models.In this research paper, we identify whether Sharpe's single factor model termed Capital Asset Pricing Model or …

Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase Open

Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra , et al. · 2022

Hepatitis E virus (HEV) is an understudied pathogen that causes infection through fecal contaminated drinking water and is prominently found in South Asian countries. The virus affects ~20 million people annually, leading to ~60,000 infect…

Review Paper on Locomotives in Trains Open

Deepak Sehgal · 2021

This document gives information about the locomotives used in the train on how to working itself by motion transfer from one to another. In this, era the steam locomotive has been transformed in appearance and characteristics. The diesel e…

Development of BacMam Induced Hepatitis E Virus Replication Model in Hepatoma Cells to Study the Polyprotein Processing Open

Manjeet Kumar, Preeti Hooda, Madhu Khanna, Utkarsh Patel, Deepak Sehgal · 2020

The processing of polyprotein(s) to form structural and non-structural components remains an enigma due to the non-existence of an efficient and robust Hepatitis E Virus (HEV) culture system. We used the BacMam approach to construct an HEV…

Hepatitis E Virus Cysteine Protease Has Papain Like Properties Validated by in silico Modeling and Cell-Free Inhibition Assays Open

Shweta Saraswat, Meenakshi Chaudhary, Deepak Sehgal · 2020

Hepatitis E virus (HEV) has emerged as a global health concern during the last decade. In spite of a high mortality rate in pregnant women with fulminant hepatitis, no antiviral drugs or licensed vaccine is available in India. HEV-protease…

Application of Support Vector Machines in Viral Biology Open

Sonal Modak, Swati Mehta, Deepak Sehgal, Jayaraman Valadi · 2019

Recent trends in antimicrobial peptide prediction using machine learning techniques Open

Yash Shah, Deepak Sehgal, Jayaraman Valadi · 2017

The importance to develop effective alternatives to known antibiotics due to increased microbial resistance is gaining momentum in recent years. Therefore, it is of interest to predict, design and computationally model Antimicrobial Peptid…

Quantitative Structure Activity Relationship study of the Anti-Hepatitis Peptides employing Random Forest and Extra Tree regressors Open

Gunjan Mishra, Deepak Sehgal, Jayaraman Valadi · 2017

Antimicrobial peptides are host defense peptides being viewed as replacement to broad-spectrum antibiotics due to varied advantages. Hepatitis is the commonest infectious disease of liver, affecting 500 million globally with reported adver…

Classification of anti hepatitis peptides using Support Vector Machine with hybrid Ant Colony Optimization Open

Gunjan Mishra, Vivek Ananth, Kalpesh Shelke, Deepak Sehgal, Jayaraman Valadi · 2016

Hepatitis is an emerging global threat to public health due to associated mortality, morbidity, cancer and HIV co-infection. Available diagnostics and therapeutics are inadequate to intercept the course and transmission of the disease. Ant…

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