Deepashri Rao
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View article: Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21
Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21 Open
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic …
View article: Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection
Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection Open
Since early 2022 highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the United States (US) with spillover into several mammalian species1-6. In March 2024, HPAIV H…
View article: A Replicating RNA Vaccine confers Durable Immunity against Lethal Crimean Congo Hemorrhagic Fever Virus Challenge in Mice
A Replicating RNA Vaccine confers Durable Immunity against Lethal Crimean Congo Hemorrhagic Fever Virus Challenge in Mice Open
Spread by Hyalomma genus ticks, Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a severe hemorrhagic disease endemic throughout Southern and Eastern Europe, Asia, and Africa. To date, there are no widely approved vaccines for CCHFV an…
View article: Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection Open
The Crimean-Congo hemorrhagic fever virus (CCHFV) causes Crimean-Congo hemorrhagic fever (CCHF), a widely distributed disease with significant morbidity and mortality. The virus has high genetic diversity correlated with geographic distrib…
View article: CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice
CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice Open
This work was supported by the Intramural Research Program of the NIH.
View article: CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir Open
There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it …
View article: Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine
Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine Open
In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within…
View article: CD47 expression attenuates Ebola virus-induced immunopathology in mice
CD47 expression attenuates Ebola virus-induced immunopathology in mice Open
It has been shown that a very early cell-intrinsic response to infection is the upregulation of CD47 cell surface expression, a molecule known for delivering a "don't eat me signal" that inhibits macrophage-mediated phagocytosis and antige…
View article: Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques
Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques Open
Patients with severe COVID-19 often have decreased numbers of T cells, a cell type important in fighting most viral infections. However, it is not known whether the loss of T cells contributes to severe COVID-19 or is a consequence of it.
View article: Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques Open
Severe COVID-19 has been associated with T cell lymphopenia 1,2 , but no causal effect of T cell deficiency on disease severity has been established. To investigate the specific role of T cells in recovery from SARS-CoV-2 infections we stu…
View article: The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir
The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir Open
HIV infects long-lived CD4 memory T cells establishing a latent viral reservoir that necessitates lifelong anti-retroviral therapy (ART). How this reservoir is formed so swiftly remains unknown. We now show the innate inflammatory response…
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dye (green).
View article: Alteration of T Cell Phenotypes in HIV‐Neurotuberculosis Coinfection
Alteration of T Cell Phenotypes in HIV‐Neurotuberculosis Coinfection Open
Background Neurotuberculosis is one of the commonest HIV associated opportunistic infections of the central nervous system in India. HIV‐TB coinfection may lead to altered frequencies of T cells, thereby influencing the course and progress…
View article: Immunogenicity and Induction of Functional Antibodies in Rabbits Immunized with a Trivalent Typhoid-Invasive Nontyphoidal Salmonella Glycoconjugate Formulation
Immunogenicity and Induction of Functional Antibodies in Rabbits Immunized with a Trivalent Typhoid-Invasive Nontyphoidal Salmonella Glycoconjugate Formulation Open
Typhoid fever due to Salmonella Typhi and invasive nontyphoidal Salmonella (iNTS) infections caused by serovars Enteritidis (SE) and Typhimurium (STm) are major pediatric health problems in sub-Saharan Africa. Typhoid has high complication…