Deepinder K. Dhaliwal
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View article: Clinical Benefits of Preservative-Free Treatment for Glaucoma with a Focus on Preservative-Free Latanoprost
Clinical Benefits of Preservative-Free Treatment for Glaucoma with a Focus on Preservative-Free Latanoprost Open
This review highlights the benefits of preservative-free topical glaucoma therapies and includes a targeted review of preservative-free latanoprost 0.005%. Recent technologic advancements including multidose preservative-free delivery syst…
View article: Translating Biomarker Discovery: From Bench to Bedside in Dry Eye Disease
Translating Biomarker Discovery: From Bench to Bedside in Dry Eye Disease Open
Dry Eye Disease (DED) is a complex, multifaceted ocular disease characterized by tear film instability and inflammation. It can sometimes be elusive to identify the type of DED in patients, given the overlapping symptoms with other conditi…
View article: TFOS DEWS III: Management and Therapy
TFOS DEWS III: Management and Therapy Open
This report provides an evidence-based review of current strategies to manage dry eye disease (DED). First-line management focuses on methods to replenish, conserve, and stimulate the tear film, with an emphasis on ocular supplements, whic…
View article: Musculoskeletal Injuries and Ophthalmologists: Prevention Requires a System-Level Approach
Musculoskeletal Injuries and Ophthalmologists: Prevention Requires a System-Level Approach Open
Musculoskeletal injuries make up about 15% of physicians’ insurance claims. These injuries lead to patient care disruptions, cancelled surgeries, significant disability, and early retirement. Dr. Rookaya Mather sat down with three fellow a…
View article: A Full Good Manufacturing Practice–Compliant Protocol for Corneal Stromal Stem Cell Cultivation
A Full Good Manufacturing Practice–Compliant Protocol for Corneal Stromal Stem Cell Cultivation Open
Corneal scarring, a significant cause of global blindness, results from various insults, including trauma, infections, and genetic disorders. The conventional treatment to replace scarred corneal tissues includes partial or full-thickness …
View article: A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021 Open
Introduction Pseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa isolates w…
View article: Rise in frequency of<i>lasR</i>mutant<i>Pseudomonas aeruginosa</i>among keratitis isolates between 1993 and 2021
Rise in frequency of<i>lasR</i>mutant<i>Pseudomonas aeruginosa</i>among keratitis isolates between 1993 and 2021 Open
Pseudomonas aeruginosa causes severe vision threatening keratitis. LasR is a transcription factor that regulates virulence associated genes in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa i…
View article: Demodex Blepharitis: A Comprehensive Review of the Disease, Current Management, and Emerging Therapies
Demodex Blepharitis: A Comprehensive Review of the Disease, Current Management, and Emerging Therapies Open
Demodex blepharitis is a common disease of the eyelid, affecting approximately 25 million Americans. This article reviews what is known about the mechanisms and impact of Demodex blepharitis, risk factors, signs and symptoms, diagnostic te…
View article: Contact Lens Safety for the Correction of Refractive Error in Healthy Eyes
Contact Lens Safety for the Correction of Refractive Error in Healthy Eyes Open
Contact lenses are a safe and effective method for correction of refractive error and worn by an estimated 45 million Americans. Because of the widespread availability and commercial popularity of contact lenses, it is not well appreciated…
View article: Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves
Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves Open
Corneal scarring is a leading cause of blindness in the world. In this study, we explored the therapeutic potential of corneal stromal stem cell (CSSC)-derived secretome in a mechanical debridement mouse model of corneal scarring. CSSC sec…
View article: Bacterial Keratitis: <i>S</i> imilar Bacterial and Clinical Outcomes in Female versus Male New Zealand White Rabbits Infected with <i>Serratia marcescens</i>
Bacterial Keratitis: <i>S</i> imilar Bacterial and Clinical Outcomes in Female versus Male New Zealand White Rabbits Infected with <i>Serratia marcescens</i> Open
This data suggests that for experimental bacterial keratitis studies involving Gram-negative rods, a single sex or mixed group of rabbit is sufficient for evaluating pathology and bacterial burdens. This will reduce the number of animals u…
View article: The Antibacterial Comparison of 5% and 2.5% Povidone Iodine to 0.01% Hypochlorous Acid Using Corneoscleral Tissue as a Solid-Phase Medium
The Antibacterial Comparison of 5% and 2.5% Povidone Iodine to 0.01% Hypochlorous Acid Using Corneoscleral Tissue as a Solid-Phase Medium Open
Five percent PI appears to be optimal as a prophylaxis prior to ocular surgery.
View article: The Rcs stress response system modulates<i>Serratia marcescens</i>induced inflammation and bacterial proliferation in a rabbit keratitis model
The Rcs stress response system modulates<i>Serratia marcescens</i>induced inflammation and bacterial proliferation in a rabbit keratitis model Open
In this study, we tested the hypothesis that the conserved bacterial Rcs stress response system mediates corneal pathogenesis associated with Serratia marcescens ocular infections. This was accomplished by modifying Rcs activity using muta…
View article: Genomic and phenotypic diversity of<i>Enterococcus faecalis</i>isolated from endophthalmitis
Genomic and phenotypic diversity of<i>Enterococcus faecalis</i>isolated from endophthalmitis Open
Enterococcus faecalis are hospital-associated opportunistic pathogens and also causative agents of post-operative endophthalmitis. Patients with enterococcal endophthalmitis often have poor visual outcomes, despite appropriate antibiotic t…
View article: Methicillin-resistant Staphylococcus aureus (MRSA) keratitis: An analysis of outcomes of cases treated initially with vancomycin versus cases treated with fluoroquinolone drops
Methicillin-resistant Staphylococcus aureus (MRSA) keratitis: An analysis of outcomes of cases treated initially with vancomycin versus cases treated with fluoroquinolone drops Open
View article: Clinical and microbial genomic features of enterococcal endophthalmitis infections
Clinical and microbial genomic features of enterococcal endophthalmitis infections Open
View article: <p>Acupuncture and dry eye: current perspectives. A double-blinded randomized controlled trial and review of the literature</p>
Acupuncture and dry eye: current perspectives. A double-blinded randomized controlled trial and review of the literature Open
Purpose: Dry eye disease (DED) is a common disorder that negatively impacts quality of life and vision. Prior studies have shown some benefit of acupuncture for dry eye, but very few have included control group to mitigate placebo e…
View article: Corneal Infections Associated with Sleeping in Contact Lenses — Six Cases, United States, 2016–2018
Corneal Infections Associated with Sleeping in Contact Lenses — Six Cases, United States, 2016–2018 Open
Contact lenses, when worn and cared for properly, are a safe and effective form of vision correction used by an estimated 45 million Americans. However, contact lens wearers are at risk for contact lens-related eye infections, especially w…
View article: Medical and surgical management of the small pupil during cataract surgery
Medical and surgical management of the small pupil during cataract surgery Open
As cataract surgery continues to evolve, the intraoperative small pupil continues to pose challenges to even the most experienced cataract surgeon. Several steps can be taken preoperatively to decrease the chance of intraoperative miosis. …
View article: DWEK vs DMEK for Treatment of Fuchs’ Endothelial Corneal Dystrophy
DWEK vs DMEK for Treatment of Fuchs’ Endothelial Corneal Dystrophy Open
View article: Efficacy of Topical 0.01% Hypochlorous Acid in Reducing Bacterial Flora on Lid Margins Compared To Topical 5% Povidone-Iodine.
Efficacy of Topical 0.01% Hypochlorous Acid in Reducing Bacterial Flora on Lid Margins Compared To Topical 5% Povidone-Iodine. Open
View article: Updates and Challenges in Refractive Lens Exchange
Updates and Challenges in Refractive Lens Exchange Open
Refractive lens exchange (RLE) is frequently used as a refractive surgical procedure for the correction of high presbyopia and high hyperopia, for which laser-assisted in situ keratomileusis (LASIK), photorefractive keratectomy (PRK) or ph…
View article: Time-Kill Comparison of Povidone Iodine to Hypochlorous Acid against Endophthalmitis Isolates of Staphylococci
Time-Kill Comparison of Povidone Iodine to Hypochlorous Acid against Endophthalmitis Isolates of Staphylococci Open
View article: Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model
Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model Open
This study presents a simple method of prophylaxis to prevent postsurgical endophthalmitis.
View article: The Threshold of Light Energy to Eliminate Acanthamoeba
The Threshold of Light Energy to Eliminate Acanthamoeba Open
View article: The Resurgence of Penicillin-Susceptible Staphylococcus aureus Isolated from Infectious Keratitis
The Resurgence of Penicillin-Susceptible Staphylococcus aureus Isolated from Infectious Keratitis Open
View article: Diffusion of Antimicrobials Across Silicone Hydrogel Contact Lenses
Diffusion of Antimicrobials Across Silicone Hydrogel Contact Lenses Open
In vitro diffusion assays demonstrate limited penetration of certain anti-infective agents through SH CLs. Further studies regarding the clinical benefit of using these agents along with bandage CL for corneal pathologic condition are warr…