Deepshika Gilbile
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View article: A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography
A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography Open
Over the past two decades, serial X-ray crystallography has enabled the structure determination of a wide range of proteins. With the advent of X-ray free-electron lasers (XFELs), ever-smaller crystals have yielded high-resolution diffract…
View article: Plug-and-play polymer microfluidic chips for hydrated room-temperature fixed-target serial crystallography
Plug-and-play polymer microfluidic chips for hydrated room-temperature fixed-target serial crystallography Open
The practice of serial X-ray crystallography (SX) depends on efficient, continuous delivery of hydrated protein crystals while minimizing background scattering. Of the two major types of sample delivery devices, fixed-target devices offer …
View article: Plug-and-play polymer microfluidic chips for hydrated, room temperature, fixed-target serial crystallography
Plug-and-play polymer microfluidic chips for hydrated, room temperature, fixed-target serial crystallography Open
This work presents our development of versatile, inexpensive, and robust polymer microfluidic chips for routine and reliable room temperature serial X-ray crystallography measurements.
View article: Crystallization of ApoA1 and ApoE4 Nanolipoprotein Particles and Initial XFEL-Based Structural Studies
Crystallization of ApoA1 and ApoE4 Nanolipoprotein Particles and Initial XFEL-Based Structural Studies Open
Nanolipoprotein particles (NLPs), also called “nanodiscs”, are discoidal particles with a patch of lipid bilayer corralled by apolipoproteins. NLPs have long been of interest due to both their utility as membrane-model systems into which m…
View article: A fixed-target platform for serial femtosecond crystallography in a hydrated environment
A fixed-target platform for serial femtosecond crystallography in a hydrated environment Open
For serial femtosecond crystallography at X-ray free-electron lasers, which entails collection of single-pulse diffraction patterns from a constantly refreshed supply of microcrystalline sample, delivery of the sample into the X-ray beam p…
View article: How Well Can You Tailor the Charge of Lipid Vesicles?
How Well Can You Tailor the Charge of Lipid Vesicles? Open
Knowledge and control of surface charge or potential is important for tailoring colloidal interactions. In this work, we compare widely used zeta potential (ζ) measurements of charged lipid vesicle surface potential to direct measurements …