Deepshikha Chandel
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View article: Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos
Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos Open
In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female b…
View article: X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes
X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes Open
Evolution of sex chromosome dosage compensation in mammals remains poorly understood. Ohno’s hypothesis state that evolution of dosage compensation occurred through two steps: first, to compensate the dosage imbalance created due to the de…
View article: Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation
Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation Open
In mammals, sex chromosome dosage is compensated through X-chromosome inactivation and active-X upregulation. It is believed that during early development, X-chromosome inactivation and active X upregulation happen in a highly coordinated …
View article: Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pre-gastrulation embryos
Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pre-gastrulation embryos Open
In recent years, allele-specific single-cell RNA-seq (scRNA-seq) analysis has demonstrated wide-spread dynamic random monoallelic expression of autosomal genes (aRME) in different cell types. However, the prevalence of dynamic aRME during …
View article: Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells
Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells Open
Recently, a unique form of X chromosome dosage compensation has been demonstrated in human preimplantation embryos, which happens through the dampening of X-linked gene expression from both X chromosomes. Subsequently, X chromosome dampeni…
View article: Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of Chromosome-wide Dampening in Naïve Human Pluripotent Stem Cells
Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of Chromosome-wide Dampening in Naïve Human Pluripotent Stem Cells Open
Recently, a unique form of X-chromosome dosage compensation has been demonstrated in human preimplantation embryos, which happens through the dampening of X-linked gene expression from both X-chromosomes. Subsequently, X-chromosome dampeni…
View article: Exome sequencing reveals a novel splice site variant in HUWE1 gene in patients with suspected Say-Meyer syndrome
Exome sequencing reveals a novel splice site variant in HUWE1 gene in patients with suspected Say-Meyer syndrome Open
Say-Meyer syndrome is a rare and clinically heterogeneous syndrome characterized by trigonocephaly, short stature, developmental delay and hypotelorism. Nine patients with this syndrome have been reported thus far although no causative gen…